When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).
Exon names are shown between parentheses on the first line.
The Cysteines involved in the IG CH1, CH2 and CH3 intrachain disulfide bridge are shown with a larger letter C in purple.
The Cysteines involved in the H-L or H-H interchain disulfide bridge are shown with a larger letter C in black.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A S P T S P K V F P L S L D S
X53706 ,IGHA2*01 (CH1) (G)CA TCC CCG ACC AGC CCC AAG GTC TTC CCG CTG AGC CTC GAC AGC
X08040 ,IGHA2*01
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
N P Q D G N V V V A C L V Q G F
X53706 ,IGHA2*01 (CH1) AAC CCC CAA ... ... ... ... GAT GGG AAC GTG GTC GTC GCC TGC CTG GTC CAG GGC TTC
X08040 ,IGHA2*01
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
F P Q E P L S V T W S E S G Q N V
X53706 ,IGHA2*01 (CH1) TTC CCC CAG ... GAG CCA CTC AGT GTG ACC TGG AGT GAA AGC GGA CAG AAC GTG ... ...
X08040 ,IGHA2*01
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
T A T N F P P S Q D A S G
X53706 ,IGHA2*01 (CH1) ... ... ACC GCC ACA AAC TTC CCA CCC AGC CAG GAT GCC TCC GGG ... ... ... ... ...
X08040 ,IGHA2*01
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
D L Y T T S S Q L T L P A T Q C L A
X53706 ,IGHA2*01 (CH1) GAC CTG TAC ACC ACG AGC AGC CAG CTG ACC CTG CCG GCC ACA CAG TGC ... ... CTA GCC
X08040 ,IGHA2*01
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G K S V T C H V T H Y T N P S Q D
X53706 ,IGHA2*01 (CH1) GGC AAG TCC GTG ACA TGC CAC GTG ACG CAC TAC ... ... ... ACG AAT CCC AGC CAG GAT
X08040 ,IGHA2*01 -- ... ... ... --- --- --- --- --- ---
119 120 121 122 123 124
V T V P C R
X53706 ,IGHA2*01 (CH1) GTG ACT GTG CCC TGC CGA G
X08040 ,IGHA2*01 --- --- --- --- --- --- -
1 2 3 4 5 6
V P P P P P
X53706 ,IGHA2*01 (H) (1) TT CCC CCA CCT CCC CCA
X08040 ,IGHA2*01 -- --- --- --- --- ---
1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
C C H P R L S L H R P A L
X53706 ,IGHA2*01 (CH2) TGC TGC CAC CCC CGA CTG TCG CTG CAC CGA CCG GCC CTC
X08040 ,IGHA2*01 --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E D L L L G S E A N L T C T L T G L
X53706 ,IGHA2*01 (CH2) GAG GAC CTG CTC TTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA CTG ACC GGC CTG
X08040 ,IGHA2*01 --
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
R D A S G A T F T W T P P S G K S
X53706 ,IGHA2*01 (CH2) AGA GAT GCC ... TCT GGT GCC ACC TTC ACC TGG ACG CCC CCA AGT GGG AAG AGC ... ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
A V Q G P P E R D L C G
X53706 ,IGHA2*01 (CH2) ... ... GCT GTT CAA GGA CCA CCT GAG CGT GAC CTC TGT GGC ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
C Y S V S S V L P G C A Q P W N H
X53706 ,IGHA2*01 (CH2) ... TGC TAT AGT GTG TCC AGT GTC CTG CCT GGT TGT GCC CAG CCA TGG ... ... AAC CAT
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G E T F T C T A A H P E L K N P L T
X53706 ,IGHA2*01 (CH2) GGG GAG ACC TTC ACC TGC ACT GCT GCC CAC CCC GAG ... ... TTG AAG AAC CCA CTA ACC
119 120 121 122 123 124
A N I T K S
X53706 ,IGHA2*01 (CH2) GCC AAC ATC ACA AAA TCC G
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
G N T F R P E V H L L P P P S
X53706 ,IGHA2*01 (CH3) GA AAC ACG TTC CGG CCC GAG GTC CAC CTG CTG CCG CCG CCG TCG
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E E L A L N E L V T L T C L A R G F
X53706 ,IGHA2*01 (CH3) GAG GAG CTG GCC CTG ... ... AAT GAG CTG GTG ACA CTG ACG TGC CTG GCA CGC GGC TTC
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
S P K D V L V R W L Q G S Q E L P R
X53706 ,IGHA2*01 (CH3) AGC CCC ... ... AAG GAC GTG CTG GTT CGC TGG CTG CAG GGG TCA CAG GAG CTG CCC CGC
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
E K Y L T W A S R Q E P S Q G T
X53706 ,IGHA2*01 (CH3) GAG ... AAG TAC CTG ACT TGG GCA TCC CGG CAG GAG CCC AGC CAG GGC ... ... ... ACC
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
T T Y A V T S I L R V A A E D W K K
X53706 ,IGHA2*01 (CH3) ACC ACC TAC GCT GTA ACC AGC ATA CTG CGC GTG GCA GCT GAG GAC TGG ... ... AAG AAA
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G D T F S C M V G H E A L P L A F T Q
X53706 ,IGHA2*01 (CH3) GGG GAC ACC TTC TCC TGC ATG GTG GGC CAC GAG GCC ... CTG CCG CTG GCC TTC ACA CAG
____________________________________CHS
119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138
K T I D R L A G K P T H I N V S V
X53706 ,IGHA2*01 (CH3) AAG ACC ATC GAC CGC CTG GCG ... ... ... GGT AAA CCC ACC CAC ATC AAT GTG TCT GTT
________________________________________
139 140 141 142 143 144 145 146 147 148
V M A E V D G T C Y *
X53706 ,IGHA2*01 (CH3) GTC ATG GCG GAG GTG GAC GGC ACC TGC TAC
IMGT note:
(1) In the IGHA gene, the hinge (H) and the (CH2) are joined in a single exon.
Created: 12/11/2002
Author: Nathalie Bosc
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