Fragment
A fragment describes a part of an immunoglobulin, T cell receptor or Major Histocompatibility Complex molecule.
A fragment may correspond to one or several domains (and/or regions) which may belong to one or several (usually two) chains.
Examples of fragments in IMGT/3Dstructure-DB:- Fragments corresponding to one domain
- CH1
- CH2
- CH3
- CH4
- VH
- V-KAPPA
- V-LAMBDA
...
- Fragments corresponding to a single chain
- L-KAPPA: light kappa chain. Kappa chains are usually found as non covalently linked light chain dimers in the crystals
- L-LAMBDA: light lambda chain. Lambda chains are usually found as non covalently linked light chain dimers in the crystals
- H-GAMMA1: heavy gamma1 chain
...
- Fragments corresponding to several domains of one chain
- CH3-CH4
- Fragments corresponding to several domains of two chains
- Fab: Fragment antigen-binding, consists of L-KAPPA or L-LAMBDA disulfide-linked with an IG heavy chain fragment consisting of VH and CH1
- Fc: Fragment crystallizable, two identical disulfide-linked fragments each comprising the CH2 and CH3 domains for alpha, gamma and delta heavy chains, or CH2, CH3 and CH4 domains for mu and epsilon heavy chains
- Fv: two V-DOMAINs of usually different chains, non covalently linked. For the IG, a VH associated with a V-KAPPA or a V-LAMBDA
- scFv
...
See also: