Polarity
The polarity is the direction of transcription of a V-GENE relative to a J-C-CLUSTER or D-J-C-CLUSTER in a same locus. There are two exclusive instances of 'polarity':
- same polarity as that of the J-C-CLUSTER or D-J-C-CLUSTER
- opposite polarity to that of the J-C-CLUSTER or D-J-C-CLUSTER
A V-GENE with a same polarity as that of the J-C-CLUSTER or D-J-C-CLUSTER rearranges by a deletional joining.
A V-GENE with an opposite polarity to that of the J-C-CLUSTER or D-J-C-CLUSTER rearranges by an inversional joining.
Reference:
[1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook,
Academic Press, 398 pages (2001) ISBN:0124413528
See also: