IMGT Lexique

IG Effector Properties

Epitope at the CH2-CH3 interface:

plays a role in conjunction with FcRn receptors, in the processing and transferring of maternal IgG [1,2]
are the target of pathogens [3,4]
His at 310 affects interaction with a variety of Fc receptors [5,6].

See also:

References:
[1]	Johanson, R. A. et al. (1981) J. Immunol 126, 194-199.
[2]	Gethie, V. and Ward, E. S. (1997) Immunol Today 18, 592-598.
[3]	Deisenhofer, J. (1981) Biochemistry 20, 2361-2370.
[4]	Kim, J. K. et al. (1999) Eur J Immunol 29, 2819-2825.
[5]	Medesan, C. et al. (1997) J. Immunol 158, 2211-2217.
[6]	West, A. P. and Bjorkman, P. J. (2000) Biochemistry 39, 9698-9708.