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Different levels of structural organization of an immunoglobulin or of a T cell receptor

The three dimensional (3D) structure of an immunoglobulin (made of two identical heavy chains and two identical light chains) or that of a T cell receptor (heterodimer) is determined as for any other protein, by the amino acid sequences of the polypetides chains and can be described in terms of different levels of folding, each of which is constructed from the preceding one in hierarchical fashion.

See also:
IMGT Index:

  • Colliers de Perles
  • Domain
  • Structure (2D, 3D)

  • IMGT Repertoire:
  • Collier de Perles: Mouse (Mus musculus) IGH V-D-J REGION from 231 (PDB: 1igt_D)

  • IMGT Education:
  • Molecular genetics of immunoglobulins (Figure 1)
  • 3D structure of an IgG immunoglobulin and its organization in domains (8 figures)
  • Strand representation of V-DOMAIN and C-DOMAIN (6 figures)
  • 3D backbone representation of V-DOMAIN and C-DOMAIN (figures and Colliers de Perles)

  • Created: 26/06/2002
    Last updated: Friday, 17-Jan-2020 21:00:15 CET
    Author: Marie-Paule Lefranc
    Editors: Amina Mrani and Chantal Ginestoux