IMGT Index

Interaction

The 'interaction' concept is part of IMGT-ONTOLOGY.

The 'interaction' concept comprises the concepts of interaction that are necessary to define interactions between components at the molecule, cell, organ, organism and/or populaton level.

At the molecular level, major concepts of interaction were generated, based on the standardized concepts of classification, description and numerotation, for example:

the 'pMHC contact site' concept
the 'IMGT Residue@Position' concept.

The 'pMHC contact site' concept allows to define peptide/MHC interactions, whereas the 'IMGT Residue@Position' concept allows to define antigen/receptor and domain interactions.

References:
[1] Kaas, Q. and Lefranc, M.-P. "T cell receptor/peptide/MHC molecular characterization and standardized pMHC contact sites in IMGT/3Dstructure-DB" In Silico Biology. Epub 2005, 5, 0046 Oct 20, 5, 505-528 (2005). PMID: 16268793
[2] Kaas, Q., Duprat, E., Tourneur, G. and Lefranc, M.-P. "IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes" In: Immunoinformatics (Schoenbach C., Ranganathan S. and Brusic V. eds.), Immunomics Reviews, Series of Springer Science and Business Media LLC, Springer, New York, USA chap. 2, pp.19-49 (2008)

ImmunoGrid, The European Virtual Human Immune System Project (IST-2004-028069)
D1.2 Scientific chart rules and ontologies report
Marie-Paule Lefranc, François Ehrenmann, Patrice Duroux and Véronique Giudicelli
Describes the IMGT-ONTOLOGY concepts of identification, description and classification at the molecular level, generated from the IDENTIFICATION, DESCRIPTION and CLASSIFICATION axioms of the Formal IMGT-ONTOLOGY (IMGT-Kaleidoscope).
D1.3 IMGT unique numbering and controlled vocabularies report
Marie-Paule Lefranc, François Ehrenmann, Patrice Duroux and Véronique Giudicelli
Describes the IMGT-ONTOLOGY concepts of numerotation at the molecular level, generated from the NUMEROTATION axiom of the Formal IMGT-ONTOLOGY (IMGT-Kaleidoscope). Two major concepts of numerotation, IMGT unique numbering and IMGT Collier de Perles, are used to define the V, C and G type domains.
D1.4 New concepts of "INTERACTION" and "LOCALIZATION" and deduced IMGT Scientific chart rules report
Marie-Paule Lefranc, François Ehrenmann, Véronique Giudicelli and Patrice Duroux
Describes IMGT-ONTOLOGY concepts of interaction for the characterization of antigen/receptor and domain interactions. Two major concepts of interaction, pMHC contact site and IMGT Residue@Position, are used, respectively, to define peptide/MHC interactions, and more generally antigen/receptor and domain interactions.

See also: