DESCRIPTION
The 'DESCRIPTION' axiom is one of the seven axioms of the Formal IMGT-ONTOLOGY or IMGT-Kaleidoscope [1-3].
The 'DESCRIPTION' axiom postulates that molecules, cells, organs, organisms or populations and their processes and relations have to be described. In molecular immunogenetics, the 'DESCRIPTION' axiom postulates that IG, TR and MHC sequences have to be described and their specific and conserved motifs be characterized [1]. The 'DESCRIPTION' axiom has generated concepts of description, for example:
- - the 'Entity Prototype' concept
- - the 'Core' concept
- - the 'Cluster' concept
- - the 'Domain' concept
References:
[1] Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999).
PMID: 10745995, LIGM:221
[2] Giudicelli, V. and Lefranc, M.-P. "Le paradigme IMGT-ONTOLOGY" In: Biologie Systémique Standards
et modèles (Roux M. Ed.), Collection Ecrin, Omniscience, Presses Universitaires de France, Paris, 2007,
Chapitre 6, pp143-164. ISBN: 978-2-916097-12-1
[3] Duroux, P. et al., "IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm", Biochimie, 90, 570-583 (2008). Epub 2007 Sep11.
PMID: 17949886
ImmunoGrid, The European Virtual Human Immune System Project (IST-2004-028069)
D1.2 Scientific chart rulesand ontologies report
Marie-Paule Lefranc, François Ehrenmann, Patrice Duroux and Véronique Giudicelli
Describes the IMGT-ONTOLOGY concepts of identification, description and classification at the molecular level,
generated from the IDENTIFICATION, DESCRIPTION and CLASSIFICATION axioms of the Formal IMGT-ONTOLOGY (IMGT-Kaleidoscope).
D1.3 IMGT unique numbering and controlled vocabularies report
Marie-Paule Lefranc, François Ehrenmann, Patrice Duroux and Véronique Giudicelli
Describes the IMGT-ONTOLOGY concepts of numerotation at the molecular level, generated from the NUMEROTATION axiom of the Formal
IMGT-ONTOLOGY (IMGT-Kaleidoscope). Two major concepts of numerotation, IMGT unique numbering and IMGT Collier de Perles, are used to define the V, C and G type domains.
D1.4 New concepts of "INTERACTION" and "LOCALIZATION" and deduced IMGT Scientific chart rules report
Marie-Paule Lefranc, François Ehrenmann, Patrice Duroux and Véronique Giudicelli
Describes IMGT-ONTOLOGY concepts of interaction for the characterization of antigen/receptor and domain interactions. Two major concepts of interaction, pMHC contact
site and IMGT Residue@Position, are used, respectively, to define peptide/MHC interactions, and more generally antigen/receptor and domain interactions.