Collier de Perles: Human IGH V-D-J-REGION from Fab-12 (PDB: 1cz8)
IMGT/3Dstructure-DB card: 1cz8
Amino acids are shown in the one-letter abbreviation.
Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50 % of analysed Ig and TcR sequences are shown in blue.
All Proline (P) are shown in yellow.
The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT. The CDR3-IMGT extend from position 105 to the position preceding J-PHE or J-TRP.
Hachured circles or squares correspond to missing positions according to the IMGT unique numbering.
Arrows indicate the direction of the beta sheets and their different designations in 3D structure. This information has to be used carefully if not supported by experimental data.
CDR-IMGT regions are colored as follows:
CDR1-IMGT (red), CDR2-IMGT (orange), CDR3-IMGT (purple)
Author: Manuel Ruiz