TRGV genes are designated according to IMGT gene tables and Locus representations.
Only FUNCTIONAL and ORF V-GENEs are shown.
The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.
Sheep TRGV genes, which have not yet been mapped, are designated by a number for the subgroup, followed by the letter S and a number.
TRGV genes |
FR1-IMGT 1 to 26 |
CDR1-IMGT 27 to 38 |
FR2-IMGT 39 to 55 |
CDR2-IMGT 56 to 65 |
FR3-IMGT 66 to 104 |
CDR3-IMGT (germline V-GENE) 105 to 115 |
(22,26,28) | (3 to 8) | (16, 17) | (6 to 8) | (36,38,39) | (4) | |
TRGV1S1 | 5 | 8 | 4* | |||
TRGV2S1 TRGV2S2 TRGV2S3 TRGV2S4 |
+2 (aa 15A,15B) +2 (aa 15A, 15B) |
6 6 3 6 |
-1 (aa 50) |
8 8 8 8 |
-3 (aa 81,82,83) -3 (aa 81,82,83) -1 (aa 82) -1 (aa 82) |
4* 4* 4* 4* |
TRGV3S1 | 8 | 7 | 4* | |||
TRGV4S1 | partial | 8 | 6 | -3 (aa 81,82,83) | 4* | |
TRGV5S1 TRGV5S2 |
-4 (aa 5 to 8) -4 (aa 5 to 8) |
5 5 |
8 8 |
-1 (aa 82) -1 (aa 82) |
4* 4* |
|
TRGV6S1 | 5 | 8 | 4* |
* Probable CDR3-IMGT length but needs to be confirmed with germline sequences.
Created: 18/12/1997
Last updated: Friday, 22-Sep-2023 18:17:50 CEST
Author: Nathalie Pallarès