Examples of C-DOMAINs: Protein displays of IG-Light C-DOMAINs: Human and mouse IGL and IGK and Teleostei IGI C-DOMAINs

The protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.

Only the *01 allele of each functional, ORF and in-frame pseudogenes C-REGION is shown.

Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

Only a few examples of Teleostei IGI C-DOMAINs are shown. 

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      IGLC, IGKC and IGIC
      genes
_____________________________________________________________________________________________________________________________________________________________________________________________
                                             A        AB     B          BC         C      CD     D          DE           E      EF   F            FG          G             CHS
                -------------->   ---------->             ------>       ------->              ----------->  ------->               ---------->
                1       10   15  16  20 23      30    36 39 41 45      77     84             85  89     96 97    104    110      118  121    130       140       150
                               7654321|........|....|123|...|...... ...|.....|  |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
IGLC
Homsap    X51755  ,IGLC1       (G)QPKANPTVTLFPPSSEELQ...ANKATLVCLIS DFYP..GAVT  VAWKADGSPVKA..GVETTKPSKQSN......NKYAASSYLSLTPEQW..KSHRSYSC QVTHE....GSTV EKTVAPTECS
Homsap    J00253  ,IGLC2       (G)QPKAAPSVTLFPPSSEELQ...ANKATLVCLIS DFYP..GAVT  VAWKADSSPVKA..GVETTTPSKQSN......NKYAASSYLSLTPEQW..KSHRSYSC QVTHE....GSTV EKTVAPTECS
Homsap    K01326  ,IGLC3       (G)QPKAAPSVTLFPPSSEELQ...ANKATLVCLIS DFYP..GPVT  VAWKADSSPVKA..GVETTTPSKQSN......NKYAASSYLSLTPEQW..KSHKSYSC QVTHE....GSTV EKTVAPTECS
Homsap    J03011  ,IGLC6       (G)QPKAAPSVTLFPPSSEELQ...ANKATLVCLIS DFYP..GAVK  VAWKADGSPVNT..GVETTTPSKQSN......NKYAASSYLSLTPEQW..KSHRSYSC QVTHE....GSTV EKTVAPAECS
Homsap    X51755  ,IGLC7       (G)QPKAAPSVTLFPPSSEELQ...ANKATLVCLVS DFYP..GAVT  VAWKADGSPVKV..GVETTKPSKQSN......NKYAASSYLSLTPEQW..KSHRSYSC RVTHE....GSTV EKTVAPAECS
Musmus    J00587  ,IGLC1       (G)QPKSSPSVTLFPPSSEELE...TNKATLVCTIT DFYP..GVVT  VDWKVDGTPVTQ..GMETTQPSKQSN......NKYMASSYLTLTARAW..ERHSSYSC QVTHE....GHTV EKSLSRADCS
Musmus    J00595  ,IGLC2       (G)QPKSTPTLTVFPPSSEELK...ENKATLVCLIS NFSP..SGVT  VAWKANGTPITQ..GVDTSNPTKEGN.......KFMASSFLHLTSDQW..RSHNSFTC QVTHE....GDTV EKSLSPAECL
Musmus    J00585  ,IGLC3       (G)QPKSTPTLTMFPPSPEELQ...ENKATLVCLIS NFSP..SGVT  VAWKANGTPITQ..GVDTSNPTKEDN.......KYMASSFLHLTSDQW..RSHNSFTC QVTHE....GDTV EKSLSPAECL
Musspr    M16554  ,IGLC2       (G)QPKSTPTLTVFPPSSEELK...ENKATLVCLIS NFSP..SGVT  VAWKANGTPITQ..GVDTSNPTKEGN.......KFMASSFLHLTSDQW..RSHNSFTC QVTHE....GDTV EKSLSPAECL
Musspr    AF357974,IGLC5       (G)QPKATPSVNLFPPSSEELK...TKKATLVCMIT EFYA..TAVR  MAWKADGTPITQ..DVETTQPPKQS........DNMASSYLLFTAEAW..ESHSSYSC HVTHE....GNTV EKNLSRAECS

IGKC
Homsap    V00557  ,IGKC         (G)TVAAPSVFIFPPSDEQLK...SGTASVVCLLN NFYP..REAK  VQWKVDNALQSG..NSQESVTEQDSKD.....STYSLSSTLTLSKADY..EKHKVYAC EVTHQG..LSSPV TKSFNRGEC
Musmus    V00807  ,IGKC         (G)ADAAPTVSIFPPSSEQLT...SGGASVVCFLN NFYP..KDIN  VKWKIDGSERQN..GVLNSWTDQDSKD.....STYSMSSTLTLTKDEY..ERHNSYTC EATHKT..STSPI VKSFNRNEC
Musspr    M21796  ,IGKC         (G)ADAAPTVSIFPPSSEQLT...SGGASVVCFLN NFYP..RDIN  VKWKIDGSERQN..GVLNSWTDQDSKD.....STYSMSSTLTLTKDEY..ERHNSYTC EATHKT..STSPI VKSFNRNEC

IGIC
Danrer     AF246185,IGIC1S1 c    (T)VSPPQVSVLQPSSAEISS..KRTATLLCVAN KGFP..SDWR  LVWKVLKPDGSSSSGGQESSSAGLLEKD.....GLYSWSSSLTLTEQQW..MESASVSC EATRSG.QPALTA GDTVRRQQCSE
Danrer AF246162,IGIC2S1 c(st)  (D)AAAAPPVLTILRPSSREELS..SSKVTLLCLIN HMSV..AFAD  VRWLVNGNSVTE...GVFTGSAEQQPD......HKFKSSSSLTIQRSEW..DKDRELTC EATVA....SKTS RASIRKSECSD
Danrer     AF246181,IGIC2S2 c  (D)AAAAPPVLTILRPSSREELS..SSKVTLLCLIN HMSV..ASAD  VRWLVNGNSVTE...GVFTGSAEQQPD......HKFKSSSSLTIQRSEW..DKDRELTC EATVA....SKTS RASIRKSECSD
Danrer     AF246193,IGIC3S1 c  (T)GSPVKPSVSLLGSSSLQSS...GDSAALLCLLS SYSP..PGAK  VSWTRDGSELSE...GFLTSAESQQDG.......RYSCTSVLKLKREEW..EKREPYAC RVTHA....GGDQ EIPFPKC

c: cDNA sequence
(st): sterile transcript

Danrer: Danio rerio (Zebrafish)
Homsap: Homo sapiens (Human)
Musmus: Mus musculus (House mouse)
Musspr: Mus spretus (Western wild mouse)

Created: 07/03/2003
Author: Delphine Guiraudou