IMGT Web resources: IMGT repertoire

Humanized antibodies
Collier de Perles: Humanized CAMPATH-1H (HuVHCAMP, mutant 1) IGH V-D-J REGION

Humanized CAMPATH-1H (HuVHCAMP, mutant 1) IGH V-D-J REGION

CDR-IMGT lengths [8.10.12]

Legend:

Human amino acids are shown in red.
Grafted rat amino acids are shown in green.
Amino acids restored by mutagenesis in amino acids corresponding to the rat sequence (designated as "backmutations") are shown in blue

Amino acids are shown in the one-letter abbreviation.
Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50 % of analysed IG and TR sequences are shown in blue.
All Proline (P) are shown in yellow.
The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT.
Hachured circles or squares correspond to missing positions according to the IMGT unique numbering.
Arrows indicate the direction of the beta sheets and their different designations in 3D structure. This information has to be used carefully if not supported by experimental data.

Created: 07/06/2001
Last updated: Friday, 22-Sep-2023 18:17:55 CEST
Author: Lisa Truong and Fatena Bellahcene