IGHC gene
and allele name (1) |
5' exon | 3' exon | codon_start | ||||
---|---|---|---|---|---|---|---|
Exons | Last complete codon (2) |
Codon resulting from splicing |
First complete codon (2) |
Exons | |||
IGHA*01 | (3) | (E) | 1.3 S TCT |
CH1 | 3 | ||
G | AG | ||||||
CH1 | 97 S TCT |
(G) | 2 P CCT |
H+CH2 | 3 | ||
G | GT | ||||||
H+CH2 | 99 T ACA |
(V) | 1.3 N AAC |
CH3 | 3 | ||
G | TG | ||||||
CH3 (4) | 107 S TCG |
(E) | 1 R CGT |
M | 3 | ||
G | AA | ||||||
IGHD*01 | (3) | (G) | 1.3 D GAT |
CH1 | 3 | ||
G | GT | ||||||
CH1 | 90 P CCT |
(E) | 2 S TCA |
H | 3 | ||
G | AG | ||||||
H | 35 E GAA |
(G) | 1.2 A GCC |
CH3 | 3 | ||
G | GG | ||||||
CH3 | 104 S AGT |
G | (G) GA |
2 C TGC |
CHS | 3 | |
(G) GC |
1.1 I ATA |
M1 | |||||
M1 | 51 K AAG |
1 V GTG |
M2 | 1 | |||
IGHE*01 | (3) | (A) | 1.3 S TCT |
CH1 | 3 | ||
G | CC | ||||||
CH1 | 88 L CTA |
(V) | 1.6 R CGA |
CH2 | 3 | ||
G | TT | ||||||
CH2 | 100 P CCA |
(D) | 1.4 H CAT |
CH3 | 3 | ||
G | AT | ||||||
CH3 | 102 P CCA |
(G) | 1.3 Q CAG |
CH4 | 3 | ||
G | GC | ||||||
CH4 (4) | 105 L CTT |
(E) | 8 L CTA |
M1 | 3 | ||
G | AG | ||||||
M1 | 51 K AAG |
1 V GTG |
M2 | 1 | |||
IGHG1*01 | (3) | (A) | 1.3 K AAA |
CH1 | 3 | ||
G | CC | ||||||
CH1 | 93 I ATT |
(V) | 2 P CCC |
H | 3 | ||
G | TG | ||||||
H | 13 T ACA |
(V) | 1.2 P CCA |
CH2 | 3 | ||
G | TC | ||||||
CH2 | 109 K AAA |
(G) | 1.3 R AGA |
CH3 | 3 | ||
G | GC | ||||||
CH3 (4) | 101 P CCT |
(G) | 9 L CTG |
M1 | 3 | ||
G | GG | ||||||
M1 | 51 K AAG |
1 V GTA |
M2 | 1 | |||
IGHG2A*01 | (3) | (A) | 1.3 K AAA |
CH1 | 3 | ||
G | CC | ||||||
CH1 | 93 I ATT |
(E) | 2 P CCC |
H | 3 | ||
G | AG | ||||||
H | 16 P CCA |
(A) | 1.5 P CCT |
CH2 | 3 | ||
G | CA | ||||||
CH2 | 109 K AAA |
(G) | 1.3 S TCA |
CH3 | 3 | ||
G | GG | ||||||
CH3 (4) | 101 P CCG |
(G) | 9 L CTA |
M1 | 3 | ||
G | GG | ||||||
M1 | 51 K AAG |
1 V GTA |
M2 | 1 | |||
IGHG2B*01 | (3) | (A) | 1.3 K AAA |
CH1 | 3 | ||
G | CC | ||||||
CH1 | 93 L CTT |
(E) | 2 P CCC |
H | 3 | ||
G | AG | ||||||
H | 22 P CCA |
(A) | 1.5 P CCT |
CH2 | 3 | ||
G | CT | ||||||
CH2 | 109 K AAA |
(G) | 1.3 L CTA |
CH3 | 3 | ||
G | GG | ||||||
CH3 (4) | 101 P CCG |
(G) | 9 L CTA |
M1 | 3 | ||
G | GG | ||||||
M1 | 51 K AAG |
1 V GTA |
M2 | 1 | |||
IGHG2C*01 | (3) | (A) | 1.3 K AAA |
CH1 | 3 | ||
G | CC | ||||||
CH1 | 93 I AAT |
(E) | 2 P CCC |
H | 3 | ||
G | AG | ||||||
H | 21 A GCA |
(A) | 1.5 P CCA |
CH2 | 3 | ||
G | CT | ||||||
CH2 | 109 R AGA |
(G) | 1.3 P CCA |
CH3 | 3 | ||
G | GG | ||||||
CH3 (4) | 101 L CTG |
(G) | 9 L CTA (5) |
M1 | 3 | ||
G | GG (5) | ||||||
M1 | 51 K AAG (5) |
1 V GTA (5) |
M2 | 1 | |||
IGHG3*01 | (3) | (A) | 1.3 T ACA |
CH1 | 3 | ||
G | CT | ||||||
CH1 | 93 I ATC |
(E) | 2 P CCT |
H | 3 | ||
G | AG | ||||||
H | 16 P CCA |
(P) | 1.5 G GGT |
CH2 | 3 | ||
C | CT | ||||||
CH2 | 109 K AAA |
(G) | 1.3 R AGA |
CH3 | 3 | ||
G | GA | ||||||
CH3 (4) | 101 P CCT |
(E) | 9 L CTG |
M1 | 3 | ||
G | AG | ||||||
M1 | 51 K AAG |
1 V GTG |
M2 | 1 | |||
IGHM*01 | (3) | (E) | 1.3 S AGT |
CH1 | 3 | ||
G | AG | ||||||
CH1 | 100 P CCA |
(A) | 1.4 V GTC |
CH2 | 3 | ||
G | CT | ||||||
CH2 | 107 A GCC |
(S) | 1.3 P CCC |
CH3 | 3 | ||
A | GT | ||||||
CH3 | 102 N AAT |
(E) | 1.4 V GTG |
CH4 | 3 | ||
G | AG | ||||||
CH4 (4) | 106 T ACT |
(E) | 14 G GGG |
M1 | 3 | ||
G | AG | ||||||
M1 | 51 K AAG |
1 V GTG |
M2 | 1 |
(1) | Only allele *01 is shown. |
(2) | Position of the last complete codon of the 5' exon and that of the first complete codon of the 3' exon are according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN. |
(3) | The last nucleotide G of the IGH J-REGION, part of the codon resulting from the splicing with CH1, is indicated for each IGHC gene. |
(4) | The donor splice of the 5' exon is an internal donor splice (INT-DONOR-SPLICE) involved in the splicing of the IGH membrane chain transcript. Synthesis of a membrane and of a secreted immunoglobulin mu heavy chain (IMGT Education) |
(5) | Defined by homology with the other IGHG2 genes. Needs to be confirmed by sequencing. |