IgG subclasses | IgG1 | IgG2 | IgG3 | |
Molecular weight of secreted form (kDa) (1) | 170 | 100 | 100 | |
Chain composition | L2γ12 | γ22 | γ32 |
IG chain types | L | γ1 | γ2 | γ3 |
Molecular weight (kDa) | 30 | 50 | 46 | 43 |
Number of variable domains | 1 | 1 | 1 | 1 |
Number of constant domains | 1 | 3 | 2 (5) | 2 (5) |
Binding to protein A | - | + | + | + |
Binding to protein G | - | + | 0 | + |
Hinge (2) | - | 11 | 35 | 12 |
Membrane IG transmembrane region (2) | - | 25 | ||
Membrane IG intracytoplasmic region (2) | - | 28 | ||
Secreted IG tailpiece (2)(3) | - | 2 | 2 | |
N-glycosylation sites (4) | 2 | 1 |
L: Light chain
(1) | Approximate molecular weight. |
(2) | Length in number of amino acids. The gamma1 hinge length is from llama (Lama glama) (AF305955) |
(3) | Encoded by CHS. |
(4) | N-glycosylation sites (NXS/T, where X is different from P). |
(5) | No CH1 domain due to an absence of splicing of the CH1 exon [1]. |
[1] | Nguyen, K.V. et al., Mol. Immunol., 36, 515-524 (1999). |
[2] | Atarhouch, T. et al., unpublished. |
[3] | Nguyen, K.V. et al., Immunogenetics, 54, 39-47 (2002) |