Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

Polymorphism by duplication of the IGLC2 and/or IGLC3 genes has been described [11,13]. The RFLP (Restriction Fragment Length Polymorphism) alleles correspond to polymorphic 8-, 13-, 18-, 23-, 28-kb EcoRI fragments [11-13,18], which contain 2, 3, 4, 5, 6 genes, respectively. So far, only the IGLC2 and IGLC3 genes of the 8-kb EcoRI fragment have been sequenced [9].

Gene table of human (Homo sapiens) IGLC (orphon) IMGT group:
IMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		ExonsR T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
IGLC/OR22-1 IGLC/OR22-1*01 P 22q12.2-22q12.3 C-REGION dJ90G24.3 (3) AL008723 [1] 42777-43090
IGLC/OR22-2 IGLC/OR22-2*01 P 22q12.2-22q12.3 C-REGION dJ149A16.1 (4) AL021937 [1] 45215-45527
IGLJ-C/OR18 (6) IGLJ-C/OR18*01 ORF (1) 18 p11.31 J-REGION AP001025 [2] 130863-130899
IGLJ-C/OR18 (6) IGLJ-C/OR18*01 ORF (2) 18 p11.31 C-REGION AP001025 [2] 130900-131211
IGLJ-C/OR18 (6) IGLJ-C/OR18*02 P 18 p11.31 C-REGION J00255 [3] (5) 202-366
IMGT notes: ↑
  1. ORF: Non canonical J-REGION: Phe-Gly-X-Lys instead of Phe-Gly-X-Gly and non canonical J-HEPTAMER
  2. AA 84.4 and 85.4 are missing
  3. dJ90G24.3 (The Sanger Center: Human chromosome 22 Home) isolated from AL008723.8 has 82.7 % identity with J00252 (IGLC1*01). Localized 16.1 Mb from the centromere of chr 22.
  4. dJ149A16.1 (The Sanger Center: Human chromosome 22 Home) isolated from AL021937.1 has 51.0 % identity with J00252 (IGLC1*01). The 5' end is telomeric whereas the 3' end is centromeric. It is localized 16.26 Mb from the centromere of chr 22.
  5. J00255 has several stop codons whereas AP001025 is an ORF.
  6. IGLJ-C/OR18 is the only known processed immunoglobulin gene, with IGHEP2.
IMGT references: ↑
  1. Dunham, I et al. “The DNA sequence of human chromosome 22.” Nature vol. 402,6761 (1999): 489-95. DOI: 10.1038/990031
  2. Hattori M. et al., Homo sapiens genomic DNA, Unpublished.
  3. Hollis G.F. et al., Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing, Nature, vol. 296, no. 5855, 1982, pp. 321-325. DOI: 10.1038/296321a0