IMGT Repertoire (IG and TR)

Alignment of alleles: house mouse (Mus musculus) TRAV12-2, TRAV12D-2 and TRAV12N-2

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Dots indicate gaps according to the IMGT unique numbering.
Blanks at the 5' and/or 3' end indicate partial sequences.
Asterisk (*) in the sequence indicate a STOP-CODON.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
Colours are according to Color menu for mutations, Color menu for sequence alignments and Color menu for splicing types.
The nucleotide (s) in bold and colored in purple (splicing frame 1) or green (splicing frame 2) from the DONOR splice site are added at the beginning of the following exon in order to obtain and to complete the first CODON of the DOMAIN or REGION resulting from the splicing site. These first CODONs are in bold and colored in purple (splicing frame 1) or green (splicing frame 2)
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown in green
Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.
                                                                                                                                
                                                
                                                 1   2   3   4   5   6   7   8   8A  9   10  11  12  13  14  15  16  17  18  19 
                                                 G   D   S   V   T   Q   T   E       G   L   V   T   L   T   E   G   L   P   V  
  AC003997   TRAV12-2*01  F   V-REGION gDNA     gga gac tca gtg acc cag aca gaa ... ggc ctg gtc act ctc acc gag ggg ttg cct gtg 

                                                                                                                                
  AE007512   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                                
  AE008685   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                                
  X04332     TRAV12D-2*01 F   V-REGION gDNA     --- --- --t --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                             K                  
  AC188458   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- a-- --- --- --- --- 

                                                                                                             K                  
  AC161460   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- a-- --- --- --- --- 

                                                                                                             K                  
  IMGT000082 TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- a-- --- --- --- --- 

                                                                                                             K                  
  X06306     TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- a-- --- --- --- --- 

                                                                                                                                
  IMGT000082 TRAV12-2*02  F   V-REGION gDNA     --- --- --t --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                             K                  
  AC005402   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- a-- --- --- --- --- 

                                                                                                             K                  
  AE007512   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- a-- --- --- --- --- 

                                                                                                             K                  
  AE008684   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- a-- --- --- --- --- 

                                                                                                             K                  
  IMGT000082 TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- a-- --- --- --- --- 

                                                                                                                                
  X04330     TRAV12D-2*03 (F) V-REGION cDNA     --- --- --t --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                             K                  
  M15063     TRAV12D-2*04 (F) V-REGION cDNA     --- --- --- --- --- --- --- --- ... --- t-- --- --- --- --- a-- --- --- --- --- 

                                                                                                             K                  
  M98569     TRAV12D-2*05 (F) V-REGION cDNA                                                 --- --- --- --- a-- --- --- --- --- 



                                                                            ___________________CDR1-IMGT____________________    
                                                
                                                 20  21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39 
                                                 M   L   N   C   T   Y   Q   T   A   Y                           S   T   F   L  
  AC003997   TRAV12-2*01  F   V-REGION gDNA     atg ctg aac tgc acc tat cag act gct tac ... ... ... ... ... ... tca act ttc ctt 

                                                                                                                                
  AE007512   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- --- --- --- 

                                                                                                                                
  AE008685   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- --- --- --- 

                                                                             S   T                                   P          
  X04332     TRAV12D-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- -g- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  AC188458   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  AC161460   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  IMGT000082 TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  X06306     TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                             S   T                                   P          
  IMGT000082 TRAV12-2*02  F   V-REGION gDNA     --- --- --- --- --- --- --- -g- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  AC005402   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  AE007512   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  AE008684   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  IMGT000082 TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                             S   T                                   P          
  X04330     TRAV12D-2*03 (F) V-REGION cDNA     --- --- --- --- --- --- --- -g- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  M15063     TRAV12D-2*04 (F) V-REGION cDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 

                                                                                 T                                   P          
  M98569     TRAV12D-2*05 (F) V-REGION cDNA     --- --- --- --- --- --- --- --- a-- --- ... ... ... ... ... ... --- c-- --- --- 



                                                                                                                _______________C
                                                
                                                 40  41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59 
                                                 F   W   Y   V   Q   H   L   N   E   A   P   K   L   L   L   K   S   S   T   D  
  AC003997   TRAV12-2*01  F   V-REGION gDNA     ttc tgg tat gtg caa cat ctc aat gaa gcc cct aaa cta ctc ctg aag agc tcc aca gac 

                                                                                                                                
  AE007512   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                                
  AE008685   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                     F          
  X04332     TRAV12D-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --t t-- --- --- -t- --- --- 

                                                                                                                                
  AC188458   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                                                                                                
  AC161460   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                                                                                                
  IMGT000082 TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                                                                                                
  X06306     TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                                                                                     F          
  IMGT000082 TRAV12-2*02  F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --t t-- --- --- -t- --- --- 

                                                                                                                                
  AC005402   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                                                                                                
  AE007512   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                                                                                                
  AE008684   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                                                                                                
  IMGT000082 TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                                                                         F           F          
  X04330     TRAV12D-2*03 (F) V-REGION cDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --t t-c --- --- -t- --- --- 

                                                                                                                                
  M15063     TRAV12D-2*04 (F) V-REGION cDNA     --- --- --- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 

                                                         H                                                                      
  M98569     TRAV12D-2*05 (F) V-REGION cDNA     --- --- c-- --- --- --- --- --c --- --- --- --g --- --- --- --- --- --- --- --- 



                                                DR2-IMGT________________                                                        
                                                
                                                 60  61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79 
                                                             N   K   R   T   E   H                       Q   G   F   H   A   T  
  AC003997   TRAV12-2*01  F   V-REGION gDNA     ... ... ... aac aag agg acc gag cac ... ... ... ... ... caa ggg ttc cac gcc act 

                                                                                                                                
  AE007512   TRAV12-2*01  F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                                
  AE008685   TRAV12-2*01  F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                         P                                                      
  X04332     TRAV12D-2*01 F   V-REGION gDNA     ... ... ... --- --- --- c-- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                     Y          
  AC188458   TRAV12N-2*01 F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                                                                     Y          
  AC161460   TRAV12N-2*01 F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                                                                     Y          
  IMGT000082 TRAV12N-2*01 F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                                                                     Y          
  X06306     TRAV12N-2*01 F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                         P                                                      
  IMGT000082 TRAV12-2*02  F   V-REGION gDNA     ... ... ... --- --- --- c-- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                     Y          
  AC005402   TRAV12D-2*02 F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                                                                     Y          
  AE007512   TRAV12D-2*02 F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                                                                     Y          
  AE008684   TRAV12D-2*02 F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                                                                     Y          
  IMGT000082 TRAV12D-2*02 F   V-REGION gDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                         P                                                      
  X04330     TRAV12D-2*03 (F) V-REGION cDNA     ... ... ... --- --- --- c-- --- --- ... ... ... ... ... --- --- --- --- --- --- 

                                                                                                                     Y          
  M15063     TRAV12D-2*04 (F) V-REGION cDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 

                                                                                                                     Y          
  M98569     TRAV12D-2*05 (F) V-REGION cDNA     ... ... ... --- --- --- --- --- --- ... ... ... ... ... --- --- --- t-- --- --- 



                                                                                                                                
                                                
                                                 80  81  82  83  84 84A  85  86  87  88  89  90  91  92  93  94  95  96  97  98 
                                                 L   H   K   S   S       S   S   F   H   L   Q   K   S   S   A   Q   L   S   D  
  AC003997   TRAV12-2*01  F   V-REGION gDNA     ctc cat aag agc agc ... agc tcc ttc cat ctg cag aag tcc tca gcg cag ctg tca gac 

                                                                                                                                
  AE007512   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                                
  AE008685   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                                                
  X04332     TRAV12D-2*01 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                             V                  
  AC188458   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                             V                  
  AC161460   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                             V                  
  IMGT000082 TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                             V                  
  X06306     TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                                                
  IMGT000082 TRAV12-2*02  F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                             V                  
  AC005402   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                             V                  
  AE007512   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                             V                  
  AE008684   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                             V                  
  IMGT000082 TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                                                
  X04330     TRAV12D-2*03 (F) V-REGION cDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                                                                                             V                  
  M15063     TRAV12D-2*04 (F) V-REGION cDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 

                                                                                                             V                  
  M98569     TRAV12D-2*05 (F) V-REGION cDNA     --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- -t- --- --- --- --- 



                                                                        ___CDR3-IMGT____
                                                
                                                 99 100 101 102 103 104 105 106 107 
                                                 S   A   L   Y   Y   C   A   L   S  
  AC003997   TRAV12-2*01  F   V-REGION gDNA     tct gcc ctg tac tac tgt gct ctg agt ga

                                                                                    
  AE007512   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- --- --- --- --- --

                                                                                    
  AE008685   TRAV12-2*01  F   V-REGION gDNA     --- --- --- --- --- --- --- --- --- --

                                                                                    
  X04332     TRAV12D-2*01 F   V-REGION gDNA     --- --- --- --- --- --- --- t-- --- --

                                                                 F                  
  AC188458   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- -t- --- --- t-- --- --

                                                                 F                  
  AC161460   TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- -t- --- --- t-- --- --

                                                                 F                  
  IMGT000082 TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- -t- --- --- t-- --- --

                                                                 F                  
  X06306     TRAV12N-2*01 F   V-REGION gDNA     --- --- --- --- -t- --- --- t-- --- --

                                                                                    
  IMGT000082 TRAV12-2*02  F   V-REGION gDNA     --- --- --- --- --- --- --- t-- --- --

                                                                 F                  
  AC005402   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- -t- --- --- t-- --- --

                                                                 F                  
  AE007512   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- -t- --- --- t-- --- --

                                                                 F                  
  AE008684   TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- -t- --- --- t-- --- --

                                                                 F                  
  IMGT000082 TRAV12D-2*02 F   V-REGION gDNA     --- --- --- --- -t- --- --- t-- --- --

                                                                                    
  X04330     TRAV12D-2*03 (F) V-REGION cDNA     --- --- --- --- --- --- --- t-- --- a-

                                                                 F                  
  M15063     TRAV12D-2*04 (F) V-REGION cDNA     --- --- --- --- -t- --- --- t-- --- -

                                                                 F                  
  M98569     TRAV12D-2*05 (F) V-REGION cDNA     --- --- --- --- -t- --- --- t-- --c c
This alignment of allele is generated by IMGT/OutilAllele (Mehdi Yousfi, Chantal Ginestoux, Perrine Pégorier and Patrice Duroux).
Created:: 05/09/2022
Last updated:: 22/09/2023
Authors:: Guilhem Zeitoun