Protein display: Common gibbon (Hylobates lar) IGH C-REGIONs

The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.

Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

The hinge exon(s) are shown at the end of the protein display.

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      IGHC
      genes
_____________________________________________________________________________________________________________________________________________________________________________________________
                                    A        AB     B          BC         C      CD     D          DE           E      EF   F            FG          G             CHS
                             -------------->   ---------->             ------>       ------->              ----------->  ------->               ---------->
                             1       10   15  16  20 23      30    36 39 41 45      77     84             85  89     96 97    104    110      118  121    130       140       150
                      7654321|........|....|123|...|...... ...|.....|  |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
  CH1
  X53708  ,IGHA1       (A)SPTSPKVFPLSLCSTQP....DGNVVVACLVQ GFFPQ.EPLS  VTWSESGQGV....TATNFPPSQDASG.....GLYTTSSQLTLPATEC..LAGKSVTC HVEHY...TNPSQ DVTVPCR
  X53709  ,IGHA2       (A)SPTSPKVFPLSLDSTQP....DGNVVVACLVQ GFFPQ.EPLN  VTWSESGQNV....TATNFPPSQDASG.....GLYTTSSQLTLPATEC..LAGKSVTC HVEHY...TNPSQ DVTVPCR
  CH2
  X53708  ,IGHA1 (1)       CCQPRLSLHRPALEDLLL..GSEANLTCTLT GLRDA.SGVT  FTWTPSSGKN....AVQGPSERDLCG.......CYSVSSILPGCAEPW..NHGKTFTC TAAQPE..SETQL TATLSKS
  X53709  ,IGHA2 (1)	   CCQPRLSLQRPALEDLLF..GSEANLTCTLT GLRDA.SGAT  FTWTPSSGKN....AVQGLPERDLCG.......CYSVSSILPGCAQPW..NNRETFTC TAEHPE..LKTPL TANITKS
  CH3
  X53708  ,IGHA1       (G)NTFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..EDVL  VRWLQGSQELPRE.KYLTWASRQEPSQG...TTTFAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEVDGTCY
  X53709  ,IGHA2      (G)KNKFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..EDVL  VRWLQGSQELPRE.KYLTWASRQEPSQG...TTTFAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEVDGTCY
  Hinge
  X53708  ,IGHA1*01	    (V)PLPTPPHP
  X53386  ,IGHA1*02         (A)TPPTPPHP
  X53709  ,IGHA2	    (A)PPPHP

IMGT note:
(1) In the IGHA gene, the hinge (H) and CH2 are joined in a single exon.

Created: 12/11/2002
Author: Nathalie Bosc