The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.

Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

The hinge exon(s) are shown at the end of the protein display.

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      IGHC
      genes
_____________________________________________________________________________________________________________________________________________________________________________________________
                                 A        AB     B          BC         C      CD     D          DE           E      EF   F            FG          G             CHS
                          -------------->   ---------->             ------>       ------->              ----------->  ------->               ---------->
                          1       10   15  16  20 23      30    36 39 41 45      77     84             85  89     96 97    104    110      118  121    130       140       150
                   7654321|........|....|123|...|...... ...|.....|  |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
  
CH1

  J00475  ,IGHA (1) (E)SARNPTIYPLTLPPVLC....SDPVIIGCLIH DYFPF.GTMN  VTWGKSGKDI....TTVNFPPALASG......GRYTMSSQLTLPAVEC..PEGESVKC SVQHD...SNPVQ ELDVNCS
  V00786  ,IGHD     (G)DKKEPDMFLLSECKAPEE...NEKINLGCLVI GSQ....PLK  ISWEPKKSSI....VEHVFPSEMRNG.......NYTMVLQVTVLASE....LNLNHTC TINKP...KRKEK PFKFP
  X01857  ,IGHE     (A)SIRNPQLYPLKPCKG......TASMTLGCLVK DYFP..NPVT  VTWYSDSLNM....STVNFPALGSE........LKVTTSQVTSWGK.....SAKNFTC HVTHP...PSFNE SRTIL
  J00453  ,IGHG1    (A)KTTPPSVYPLAPGSAAQT...NSMVTLGCLVK GYFP..EPVT  VTWNSGSLSS....GVHTFPAVLESD.......LYTLSSSVTVPSSPR...PSETVTC NVAHPA..SSTKV DKKI
  V00825  ,IGHG2A   (A)KTTAPSVYPLAPVCGDTT...GSSVTLGCLVK GYFP..EPVT  LTWNSGSLSS....GVHTFPAVLQSD.......LYTLSSSVTVTSSTW...PSQSITC NVAHPA..SSTKV DKKI
  V00763  ,IGHG2B   (A)KTTPPSVYPLAPGCGDTT...GSSVTSGCLVK GYFP..EPVT  VTWNSGSLSS....SVHTFPALLQSG.......LYTMSSSVTVPSSTW...PSQTVTC SVAHPA..SSTTV DKKL
  J00479  ,IGHG2C   (A)KTTAPSVYPLAPVCGGTT...GSSVTLGCLVK GYFP..EPVT  LTWNSGSLSS....GVHTFPALLQSG.......LYTLSSSVTVTSNTW...PSQTITC NVAHPA..SSTKV DKKI
  X00915  ,IGHG3    (A)TTTAPSVYPLVPGCSDTS...GSSVTLGCLVK GYFP..EPVT  VKWNYGALSS....GVRTVSSVLQSG.......FYSLSSLVTVPSSTW...PSQTVIC NVAHPA..SKTEL IKRI
  V00818  ,IGHM     (E)SQSFPNVFPLVSCESPLSD..KNLVAMGCLAR DFLP..STIS  FTWNYQNNTEVIQ.GIRTFPTLRTGG.......KYLATSQVLLSPKSILEGSDEYLVC KIHYG....GKNR DLHVPIP
 
CH2

  J00475  ,IGHA         SCQPSLSLQRPALEDLLL..GSDASITCTLN GLRNP.EGAA  FTWEPSTGKD....AVQKKAAQNSCG.......CYSVSSVLPGCAERW..NSGASFKC TVTHPE..SGTLT GTIAKVT
  X01857  ,IGHE  (V)RPVNITEPTLELLHSSCDPNAF..HSTIQLYCFIY GHIL..NDVS  VSWLMDDREITD..TLAQTVLIKEEG......KLASTCSKLNITEQQW..MSESTFTC KVTSQ....GVDY LAHTRRCP
  J00453  ,IGHG1     (V)PEVSSVFIFPPKPKDVLTI.TLTPKVTCVVV DISKDDPEVQ  FSWFVDDVEVH...TAQTQPREEQFN......STFRSVSELPIMHQDW..LNGKEFKC RVNSAA..FPAPI EKTISKTK
  V00825  ,IGHG2A (A)PNLLGGPSVFIFPPKIKDVLMI.SLSPIVTCVVV DVSEDDPDVQ  ISWFVNNVEVH...TAQTQTHREDYN......STLRVVSALPIQHQDW..MSGKEFKC KVNNKD..LPAPI ERTISKPK
  V00763  ,IGHG2B (A)PNLEGGPSVFIFPPNIKDVLMI.SLTPKVTCVVV DVSEDDPDVQ  ISWFVNNVEVH...TAQTQTHREDYN......STIRVVSTLPIQHQDW..MSGKEFKC KVNNKD..LPSPI ERTISKIK
  J00479  ,IGHG2C (A)PDLLGGPSVFIFPPKIKDVLMI.SLSPMVTCVVV DVSEDDPDVQ  ISWFVNNVEVH...TAQTQTHREDYN......STLRVVSALPIQHQDW..MSGKEFKC KVNNRA..LPSPI EKTISKPR
  X00915  ,IGHG3  (P)GNILGGPSVFIFPPKPKDALMI.SLTPKVTCVVV DVSEDDPDVH  VSWFVDNKEVH...TAWTQPREAQYN......STFRVVSALPIQHQDW..MRGKEFKC KVNNKA..LPAPI ERTISKPK
  V00818  ,IGHM    (A)VAEMNPNVNVFVPPRDGFSGPAPRKSKLICEAT NFTP..KPIT  VSWLKDGKLVES..GFTTDPVTIENKGS..TPQTYKVISTLTISEIDW..LNLNVYTC RVDHR....GLTF LKNVSSTCAA
  
CH3

  J00475  ,IGHA     (V)NTFPPQVHLLPPPSEELAL..NELLSLTCLVR AFNP..KEVL  VRWLHGNEELSPE.SYLVFEPLKEPGEG...ATTYLVTSVLRVSAETW..KQGDQYSC MVGHEA.LPMNFT QKTIDRLS...GKPTNVSVSVIMSEGDGICY
  V00788  ,IGHD      (G)AMAPSNLTVNILTTSTHP..EMSSWLLCEVS GFFP..ENIH  LMWLGVHSKMKST.NFVTANPTAQPG......GTFQTWSVLRLPVALS..SSLDTYTC VVEHEASKTKLNA SKSLAIS   (G)CYHLLPESDGPSRRPDGPALA (J00450)
  X01857  ,IGHE    (D)HEPRGVITYLIPPSPLDLYQ..NGAPKLTCLVV DLESE.KNVN  VTWNQEKKTSV...SASQWYTKHHNN......ATTSITSILPVVAKDW..IEGYGYQC IVDHPD..FPKPI VRSITKTP
  J00453  ,IGHG1 (2)(G)RPKAPQVYTIPPPKEQMA...KDKVSLTCMIT DFFP..EDIT  VEWQWNGQPAE...NYKNTQPIMNTN......GSYFVYSKLNVQKSNW..EAGNTFTC SVLHEG.LHNHHT EKSLSHSP...GK
  V00825  ,IGHG2A   (G)SVRAPQVYVLPPPEEEMT...KKQVTLTCMVT DFMP..EDIY  VEWTNNGKTEL...NYKNTEPVLDSD......GSYFMYSKLRVEKKNW..VERNSYSC SVVHEG.LHNHHT TKSFSRTP...GK
  V00763  ,IGHG2B   (G)LVRAPQVYTLPPPAEQLS...RKDVSLTCLVV GFNP..GDIS  VEWTSNGHTEE...NYKDTAPVLDSD......GSYFIYSKLNMKTSKW..EKTDSFSC NVRHEG.LKNYYL KKTISRSP...GK
  J00479  ,IGHG2C   (G)PVRAPQVYVLPPPAEEMT...KKEFSLTCMIT GFLP..AEIA  VDWTSNGRTEQ...NYKNTATVLDSD......GSYFMYSKLRVQKSTW..ERGSLFAC SVVHEV.LHNHLT TKTISRSL...GK
  X00915  ,IGHG3    (G)RAQTPQVYTIPPPREQMS...KKKVSLTCLVT NFFS..EAIS  VEWERNGELEQ...DYKNTPPILDSD......GTYFLYSKLTVDTDSW..LQGEIFTC SVVHEA.LHNHHT QKNLSRSP...GK
  V00818  ,IGHM     (S)PSTDILTFTIPPSFADIFL..SKSANLTCLVS NLATY.ETLN  ISWASQSGEPL...ETKIKIMESHPN......GTFSAKGVASVCVEDW..NNRKEFVC TVTHRD..LPSPQ KKFISKPN
  
CH4

  X01857  ,IGHE     (G)QRSAPEVYVFPPPEEES....EDKRTLTCLIQ NFFP..EDIS  VQWLGDGKLISNS.QHSTTTPLKSNGS....NQGFFIFSRLEVAKTLW..TQRKQFTC QVIHEALQKPRKL EKTISTSL...GNTSLRPS
  V00818  ,IGHM    (E)VHKHPPAVYLLPPAREQLNL..RESATVTCLVK GFSP..ADIS  VQWLQRGQLLPQE.KYVTSAPMPEPGA....PGFYFTHSILTVTEEEW..NSGETYTC VVGHEA.LPHLVT ERTVDKST...GKPTLYNVSLIMSDTGGTCY

  
CONNECTING-REGION, TRANSMEMBRANE-REGION and CYTOPLASMIC-REGION

                                                            M
  K00691  ,IGHA        (E)RQEPLSYVLLDQSQDILEEEAPGASLWPTTVTFLTLFLLSLFYSTALTVTTVRGPFGSKEVPQY

                                                   M1                           M2
  J00450  ,IGHD       (G)IVNTIQHSCIMDEQSDSYMDLEEENGLWPTMCTFVALFLLTLLYSGFVTFIK  VK
  X03624  ,IGHE               (E)LDLQDLCIEEVEGEELEELWTSICVFITLFLLSVSYGATVTVLK  VKWVWLSTPMQDTPQTFQDYANILQTRA
  J00454  ,IGHG1               (G)LQLDETCAEAQDGELDGLWTTITIFISLFLLSVCYSAAVTLFK  VKWIFSSVVELKQTLVPEYKNMIGQAP
  J00471  ,IGHG2A              (G)LDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK  VKWIFSSVVELKQTISPDYRNMIGQGA
  J00462  ,IGHG2B              (G)LDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFK  VKWIFSSVVELKQKISPDYRNMIGQGA
  X00915  ,IGHG3               (E)LELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK  VKWIFSSVVQVKQTAIPDYRNMIGQGA
  J00444  ,IGHM                     (E)GEVNAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFK  VK
                              CONNECTING-REGION    |    TRANSMEMBRANE-REGION   | CYTOPLASMIC-REGION
  
HINGE-REGION

  J00475  ,IGHA*01    (G)PTPPPPITIP
  AF175974,IGHA*04    (G)ICSPPTTPPPP
  AY045742,IGHA*06    (G)PPPPCPPCPP
  AY045748,IGHA*07    (G)PPPPCPP
  AY045751,IGHA*08    (G)PPPPCPPLP
  V00787  ,IGHD       (E)SWDSQSSKRVTPTLQAKNHSTEATKAITTKKDIE
  J00453  ,IGHG1      (V)PRDCGCKPCICT
  V00825  ,IGHG2A     (E)PRGPTIKPCPPCKCP
  V00763  ,IGHG2B     (E)PSGPISTINPCPPCKECHKCP
  J00479  ,IGHG2C     (E)PRVPITQNPCPPLKECPPCA
  X00915  ,IGHG3      (E)PRIPKPSTPPGSSCP
IMGT note:
(1)N 122 is polymorphic.
(2)N 84.4 is polymorphic.