IMGT Repertoire (IG and TR)

The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

The hinge exon(s) are shown at the end of the protein display.

               A       AB      B          BC        C     CD      D          DE           E      EF   F          FG            G              CHS
            (1-15)          (16-26)    (27-38)   (39-45)       (77-84)                 (85-96)     (97-104)   (105-117)    (118-128)   
        ——————————————>   ——————————>            ——————>       ———————>              ———————————>  ———————>               ——————————>
IGHC genesAccNum
        1        10  15   16  20 2326 27      38 3941 45       77 80 84              85  89    96  97   104 105       117 118        130       140      150
 
87654321|........|....|123|...|..|..| |........| |.|...|1234567|..|...|12345677654321|...|......|12|......| |...........| |...........|.........|.........|
CH1
IGHAAABR03049801
....ESAKDPTIYPLRPPPSPS....SDPVTIGCLIQ NYFPS.GTMN VTWGKSGKDI....SVINFPPAPASG.......PYTMCSQLTLPAAEC..PKGTSVKY YVQYN...TSPVR ELSVECP
IGHDAABR03049259
....APEKEPDLFLSSECKAPNQ...NEHVNVSCMAI GVQ....PLT LAWEPTLPST....VFSGTNKDEY...........ITILQVSVPAP....NLSPNLTC TITNTS..KKKSK TFKLP
IGHEK02901
....VSVKAPSLYPLKPCSSEN....TASVTLGCLVK DYFP..DPVT VTWYSDSLNT....STMNFPSVGSD........LKTTTSQMTSWGK.....SAKNFTC HVTHA...PSTFV SDLTIR
IGHG1AABR03048905
....AETTAPSVYPLAPGTALKS...NSMVTLGCLVK GYFP..EPVT VTWNSGALSS....GVHTFPAVLQSG.......LYTLTSSVTVPSSTW...PSQTVTC NVAHPA..SSTKV DKKI
IGHG2AAABR03049560
....AETTAPSVYPLAPGTALKS...NSMVTLGCLVK GYFP..EPVT VTWNSGALSS....GVHTFPAVLQSG.......LYTLTSSVTVPSSTW...SSQAVTC NVAHPA..SSTKV DKKI
IGHG2BAABR03048905
....AQTTAPSVYPLAPGCGDTT...SSTVTLGCLVK GYFP..EPVT VTWNSGALSS....DVHTFPAVLQSG.......LYTLTSSVT..SSTW...PSQTVTC NVAHPA..SSTKV DKKV
IGHG2CAABR03049912
....ARTTAPSVYPLVPGCSGTS...GSLVTLGCLVK GYFP..EPVT VKWNSGALSS....GVHTFPAVLQSG.......LYTLSSSVTVPSSTW...SSQTVTC SVAHPA..TKSNL IKRI
IGHMAABR03049259
....ESQSSPTVFPLVSCESPLSD..ENLVAMGCLAR DFLP..SSIS FSWNYQNNTEVMQ.GVRTFPTLRTGD.......KYTATSQVLLSAKNVLEGSDEYLVC KIHHG....NKNK DLHVPIP
CH2
IGHAAABR03049801
......VCRPRLSLQRPALEDLLL..GSEASLTCTLR GLKEP.TGAV FTWQPTTGKD....AVQKEAVQDSCG.......CYTVSSVLPGCAERW..NNGETFTC TATHPEF.ETPLT GEIAKVT
IGHEK02901
.ARPVNITKPTVDLLHSSCDPNAF..HSTIQLYCFVY GHIQ..NDVS IHWLMDDRKIYE..THAQNVLIKEEG......KLASTYSRLNITQQQW..MSESTFTC KVTSQ....GENY WAHTRRCS
IGHG1AABR03048905
.....GSEVSSVFIFPPKPKDVLTI.TLTPKVTCVVV DISQDDPEVH FSWFVDDVEVH...TAQTRPPEEQFN......STFRSVSELPILHQDW..LNGRTFRC KVTSAA..FPSPI EKTISKPE
IGHG2AAABR03049560
.....GSEVSSVFIFPPKTKDVLTI.TLTPKVTCVVV DISQNDPEVR FSWFIDDVEVH...TAQTHAPEKQSN......STLRSVSELPIVHRDW..LNGKTFKC KVNSGA..FPAPI EKSISKPE
IGHG2BAABR03048905
..VPELLGGPSVFIFPPKPKDILLI.SQNAKVTCVVV DVSEEEPDVQ FSWFVNNVEVH...TAQTQPREEQYN......STFRVVSALPIQHQDW..MSGKEFKC KVNNKA..LPSPI EKTISKPK
IGHG2CAABR03049912
..CDDNLGRPSVFIFPPKPKDILMI.TLTPKVTCVVV DVSEEEPDVQ FSWFVDNVRVF...TAQTQPHEEQLN......GTFRVVSTLHIQHQDW..MSGKEFKC KVNNKD..LPSPI EKTISKPR
IGHMAABR03049259
...AVVEMNPNVSVFIPPRDAFSGPAPRKSRLICEAT NFSP..KQIT VSWLQDGKPVKS..GFTTEPVTVEAKGS..RPQTYKVISTLTITESDW..LNLNVFTC RVDHR....GLTF WKNVSSTCAA
CH3
IGHAAABR03049801
....ENTFPPQVHLVPPPSEELAL..NELVSLTCLVR GFNP..KDVL VRWLQGNEELPSE.SYLVFEPLREPGEG...AITYLVTSVLRVSAETW..KQGAQYSC MVGHEA.LPMSFT QKTIDRLS...GKPTNVNVSVIMSEGDGICY
IGHDAABR03049259
.....GAMAPSNLNVNILTTFTHH..EMSSWLMCEVS GFYP..EDIH LWWLSAQTKMDPI.NFVTAQPVRQSG......DKFQIWSVLRLPVALS..PSLDTYTC VVEHEASQTKLNA SKSLEIS    GCYHLLPESDGPPRRPDGPAFP
IGHEK02901
...DDEPRGVITYLIPPSPLDLYE..NGTPKLTCLVL DLESE.ENIT VTWVRERKKSI...GSASQRSTKHHN......ATTSITSILPVDAKDW..IEGEGYQC RVDHPH..FPKPI VRSITKAP
IGHG1AABR03048905
....GRTQVPHVYTMSPTKEEMT...QNEVSITCMVK GFYP..PDIY VEWQMNGQPQE...NYKNTPPTMDTD......GSYFLYSKLNVKKEKW..QQGNTFTC SVLHEG.LHNHHT EKSLSHSP...GK
IGHG2AAABR03049560
....GTPRGPQVYTMAPPKEEMT...QSQVSITCMVK GFYP..PDIY TEWKMNGQPQE...NYKNTPPTMDTD......GSYFLYSKLNVKKETW..QQGNTFTC SVLHEG.LHNHHT EKSLSHSP...GK
IGHG2BAABR03048905
....GLVRKPQVYVMGPPTEQLT...EQTVSLTCLTS GFLP..NDIG VEWTSNGHIEK...NYKNTEPVMDSD......GSFFMYSKLNVERSRW..DSRAPFVC SVVHEG.LHNHHV EKSISRPP
IGHG2CAABR03049912
....GKARTPQVYTIPPPREQMS...KNKVSLTCMVT SFYP..ASIS VEWERNGELEQ...DYKNTLPVLDSD......ESYFLYSKLSVDTDSW..MRGDIYTC SVVHEA.LHNHHT QKNLSRSP...GK
IGHMAABR03049259
....SPSTDILAFPIPPSFADIFL..TKSAKLSCLVT NLATY.DTLN ISWSSKSGEPL...ETNTKIMESHPN......GTFSAVGVASVCMEDW..DNRKEFVC TVTHRD..LPSPQ KKFISKPN
CH4
IGHEK02901
....GKRSAPEVYVFLPPEEEE....KDKRTLTCLIQ NFFP..EDIS VQWLQDSKLIPKS.QHSTTTPLKYNGS....NQRFFIFSRLEVTKALW..TQTKQFTC RVIHEALREPRKL ERTISKSL...GNTSLRPSQASM
IGHMAABR03049259
...EVAKHPPAVYLLPPAREQLIL..RESATVTCLVK GFSP..ADIF VQWLQRGQPLSSD.KYVTSAPMPEPGA....PGLYFTHSILTVTEEEW..NSGETYTC VVGHEA.LPHMVT ERTVDKST...GKPTLYNVSLIMSDTGGTCY
CONNECTING-REGION, TRANSMEMBRANE-REGION and CYTOPLASMIC-REGION 
                                       M
IGHAAABR03049801
 ECQEPPSYVILDQSQDILEEETPGASLWPTAVTFLTLFLLSLFYSTALTVTTVRGPFGSKEVPQY
                          M1                           M2
IGHDAABR03049259
GMVDTIPNSCIRDEQTDSYVDIEEENGLWPTLCTFVALFLLTLLYSGFVTFIK  VK
IGHEK02901
        ELDIQDLCTEEVEGEELEELWTSTYIFISLFLLSVSYGATVTVLK  VKWVFSTLMHDTPQTFQDYANILQTRA
IGHG1AABR03048905
         GMEVDDACAEAQDGELDGLWTTITIFISLFLLSVCYSAAVTLFK  VKWIFSSVVGLKQTLVPEYKNMIGQGP
IGHG2AAABR03049560
         GMEVDDACAEAQDGELEGLWTTITIFISLFLLSVCYSAAVTLFK  VKWIFSSVVELKKTLVPEYKNMIGQGP
IGHG2BAABR03048905
          LEVDDDCAEAQDGELDGLWTTITIFISLFLLSVCYSASITLFK  VKWIFSSVVELKQTISPDYRNMIGQGA
IGHG2CAABR03049912
         ELELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFK  VKWIFSSVVQVKQTMVPDYRNMIGQGA
IGHMAABR03049259
              EGEVNAEEEGFENLWTTASTFIVLFLLSLFYSTTVTLFK  VK
       CONNECTING-REGION   |   TRANSMEMBRANE-REGION    |   CYTOPLASMIC-REGION
HINGE-REGION
IGHAAABR03049801
GPKPSL
IGHDAABR03049259
ETRNSQSSKKANPTPQAKNHYIEATKPTATKNIV
IGHG1AABR03048905
VPRNCGGDCKPCICT
IGHG2AAABR03049560
VPRECNPCGCT
IGHG2BAABR03048905
ERRNGGIGHKCPTCPTCHKCP
IGHG2CAABR03049912
EPRRPKPRPPTDICS