Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
The TRGC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
To take into account the similitude between the organization of the ovine and bovine TRG loci, the ovine C6, C1 and C4 genes, described in [1] have been officially named as TRGC1, TRGC4 and TRGC6, respectively (20/04/2006).
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TRGC
genes
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A B BC C D E F G
---------------> ----------> -----> -----------> --------------> -------------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 114 120 130
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|............|...|.....|.........|
EX1
AF312559,TRGC1*01 (E)RNLAADTSPKPTVFLPSIAEINH..DNAGTYLCLLE KFFP..DVIT VSWRVKNDKRAL..PSQQGNTMKTK.......DTYMKLSWLTVTEN....SMDKQHVCVVKHQKNIGGIDQEIIFPSIKE
Z12965 ,TRGC2*01 (E)RNLAADTSPKPTVFLPSIAEINH..DNAGTYLCLLE KFFP..DVIT VSWRVKNDKRAL..PSQQGNTMKTK.......DTYMKLSWLTVTEN....SMDKQHVCVVKHQKNIGGIDQEIIFPSIKE
Z12966 ,TRGC3*01 (D)RDLDKDMSPKPTMFLPSITEIKR..DNSGTYLCLLE DFFP..HVIK VYWREKRGNKVL..PSQEGKTIKTL.......DTYMKFSWLTVSGN....SMDKEHMCIVKHEKNKRGTNQEILFPAVNE
Z12964 ,TRGC4*01 (N)RNLATDLSPKPIIFLPSIAEINH..SKTGTYLCLLE KFFP..DIIK VYWKEKDGNRAL..PSQQGNTMNTT.......DTYMKLSWLTVTEN....SMDKEHICVVQHERNIRGINQEILFPSINE
Z13986 ,TRGC5*01 (D)RRLDGDLFPKPTIFFPSVEEVKR..HSAGTHLCLLQ NFFP..DAIK VQWKEKNGNTIL..ESHQGNIIKTN.......DTYMKFSWLTLTKK....AMGKEHVCIVKHENNKGGRDQEILFSPVNK
AF241307,TRGC6*01 (D)KNLPTDIIPKPTIFLPSINEVNH..QQTATYLCLLE NFFP..DVIK VSWKEKNGKRVL..PSQQGNTMKTN.......NTYMKFSWLTVTED....SMKKEHMCIVRLEKNAGGKDQEILFPAVNE
CONNECTING-REGION TRANSMEMBRANE-REGION CYTOPLASMIC-REGION
[EX2A] [EX2B] [EX2C] [EX3]
AF312560/1,TRGC1*01 (V)VTSAVTTTKPP..........NDCLTDES (S)ALRLQLTTTSAYNTYLLLLLLSTVYFVVIISCVFRRTGVWSDWKIS
Z12965 ,TRGC2*01 (V)VTSAVTTTEPPTTEPPTTEPPNDCLTDES (K)VTGTGSKTACLKDER (E)VTGDTNSTKACQEGES (S)ALRLQLTTTSAYYTYLLLLLLSTVYFVVIISCVFRRTGNCCDGKIS
Z12966 ,TRGC3*01 (V)VSSVVTTTKPPNDGLKDKS (E)KQVPVANSTKACLKDEN (N)TLQLQLMSTSAYYTYLLLLIKSTAYFAIITSCVFRRTGVCGNQKSS
Z12964 ,TRGC4*01 (V)VSSIVPTTESPSDCLNQES (K)VTGTGSKKACLKDES (E)VTADNNSTKVCLEDES (N)TLQLQLMNTSAYYTYLLLLLKSVVYFIIITSCVFRRTGMCCDGKNL
Z13986 ,TRGC5*01 (E)VATHACMKKGS (D)TLQLQFASTSAYYTYLLLLLKSMIYFSIIAFCVFWRIGIFSNGKIF
AF241308/9,TRGC6*01 (V)FSPVVATTEPPDDCLQDES (E)VTDTDFTKVCSRGES (E)VTDSTKACLKDEN (N)TVELQLAYNSAYYTYLLLLLKSAIYFVTSSCCVFRRTGVCHDGKSS
| [1] | Miccoli, M.C. et al., J. Mol. Evol. 57, 52-62 (2003). PMID: 12962306 |