Table of alleles: Human IGKV

Print of this table: Barbié, V. and Lefranc, M.-P., Exp. Clin. Immunogenet., 15, 171-183 (1998). PMID:9813414

The IMGT allele table refers to the V-REGION polymorphism. It does not include polymorphisms in the other parts of the V-GENE. V-REGION alleles are only described for genes which have at least one Functional or ORF allele. The accession number of a reference sequence is given for each allele.

Click on a gene name to get the alignment of the corresponding V-REGION alleles.
Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).

IGKV
subgroup		 IGKV
gene name		 Fct IGKV
allele name		 Accession number Confirmed
by genetics
and/or data		 Description of mutations
1 IGKV1-5 F IGKV1-5*01 Z00001 + 
c65  , T22  |g166  ,t168  ,D56  |c171  |c174  |g201  |
F IGKV1-5*02 M23851   
c65>t, T22>I|
F IGKV1-5*03 X72813   
            |g166>a,t168>g,D56>K|c171>g|c174>t|g201>a|
IGKV1-6 F IGKV1-6*01 M64858 +  
IGKV1-8 F IGKV1-8*01 Z00014    
IGKV1D-8 F IGKV1D-8*01 Z00008 +  
IGKV1-9 F IGKV1-9*01 Z00013 +  
IGKV1-12 F IGKV1-12*01 V01577 + 
            |c334  |
IGKV1D-12 F IGKV1D-12*01 X17263 + 
t30  |t270  |c334  |
IGKV1-12/IGKV1D-12 (1) F IGKV1-12*02/1D-12*02 V01576   
	    |c334>t| (if IGKV1-12*02)

t30>c|t270>c|c334>t| (if IGKV1D-12*02)
IGKV1-13 P IGKV1-13*01 Z00010 + 
a123  ,*41  |a326  ,N109  |
F IGKV1-13*02 Z00006   
a123>g,*41>W|a326>g,N109>S|
IGKV1D-13 F IGKV1D-13*01 X17262   
            |a326  ,N109  |
IGKV1-16 F IGKV1-16*01 J00248   
g224  ,R75  |
[F] IGKV1-16*02 FM164406   
g224>a,R75>K|
IGKV1D-16 F IGKV1D-16*01 K01323 + 
t78  ,S26  |
F IGKV1D-16*02 V00558 + 
t78>g,S26>R|
IGKV1-17 F IGKV1-17*01 X72808 + 
g278   ,S93   |
F IGKV1-17*02 D88255   
g278>a ,S93>N |
IGKV1D-17 F IGKV1D-17*01 X63392   
a1  ,N1  |a155  ,H52  |
[F] IGKV1D-17*02 FM164407   
a1>g,N1>D|a155>g,H52>R|
IGKV1-27 F IGKV1-27*01 X63398 +  
IGKV1-33 F IGKV1-33*01 M64856 +  
IGKV1D-33 F IGKV1D-33*01 M64855 +  
IGKV1-37 ORF IGKV1-37*01 X59316    
IGKV1D-37 ORF IGKV1D-37*01 X71893    
IGKV1-39 F IGKV1-39*01 X59315 + 
c29  ,S10  |c306  |a315  |c316  ,a317  ,g318  ,Q106  |a319  ,S107  |c330  |
P IGKV1-39*02 X59318   
c29>t,S10>F|c306>t|a315>g|c316>t,a317>g,g318>t,Q106>C|a319>g,S107>G|c330>a|
IGKV1D-39 F IGKV1D-39*01 X59312    
IGKV1D-42 ORF IGKV1D-42*01 X72816    
IGKV1D-43 F IGKV1D-43*01 X72817 +  
2 IGKV2-24 F IGKV2-24*01 X12684 +  
IGKV2D-24 ORF IGKV2D-24*01 X63401 +  
IGKV2-28 F IGKV2-28*01 X63397    
IGKV2D-28 F IGKV2D-28*01 X12691 +  
IGKV2-29 P IGKV2-29*01 X63396 + 
g159  |a312  ,*104  |
F IGKV2-29*02 U41645   
g159>a|a312>c,*104>C|
F IGKV2-29*03 AJ783437   
      |a312>c,*104>C|
IGKV2D-29 F IGKV2D-29*01 M31952 + 
c145  ,P49  |
F(2) IGKV2D-29*02 U41644   
c145>t,P49>S|
IGKV2-30 F IGKV2-30*01 X63403 + 
t91  ,Y31  |
[F] IGKV2-30*02 FM164408   
t91>c,Y31>H|
IGKV2D-30 F IGKV2D-30*01 X63402 +  
IGKV2-40 F IGKV2-40*01 X59314   
c120  |g123  ,W41  |g233  ,G78  |
F IGKV2-40*02 X59317   
c120>t|g123>t,W41>C|g233>a,G78>D|
IGKV2D-40 F IGKV2D-40*01 X59311    
3 IGKV3-7 ORF IGKV3-7*01 X02725   
a118  ,T40  |t126  |c141  |g147  |a208  ,S70  |c571  ,T85  |c322  ,H108  |
ORF IGKV3-7*02 X72812   
a118>t,T40>S|t126>c|c141>g|g147>t|a208>g,S70>G|            |c322>t,H108>Y|
ORF IGKV3-7*03 K02769   
                                              |c571>g,T85>R|
[ORF] IGKV3-7*04 FM164409   
                                                           |c322>t,H108>Y|
IGKV3D-7 F IGKV3D-7*01 X72820 +  
IGKV3-11 F IGKV3-11*01 X01668 + 
c568  ,T85  |
F IGKV3-11*02 K02768 + 
c568>g,T85>R|
IGKV3D-11 F IGKV3D-11*01 X17264 +  
IGKV3-15 F IGKV3-15*01 M23090 +  
IGKV3D-15 F IGKV3D-15*01 X72815 + 
c14  ,T5  |g330  ,W110  |
P IGKV3D-15*02 M23091   
c14>t,T5>M|g330>a,W110>*|
IGKV3-20 F IGKV3-20*01 X12686 + 
g15  |g26  ,G9  |a221  ,c222  ,D74  |g303  |
F IGKV3-20*02 L37729   
g15>a|g26>c,G9>A|a221>c,c222>a,D74>A|g303>t|
IGKV3D-20 F IGKV3D-20*01 X12687 +  
4 IGKV4-1 F IGKV4-1*01 Z00023 +  
5 IGKV5-2 F IGKV5-2*01 X02485    
6 IGKV6-21 ORF IGKV6-21*01 X63399    
IGKV6D-21 ORF IGKV6D-21*01 X12683 +  
IGKV6D-41 ORF IGKV6D-41*01 M27751 (3) +  

IMGT notes:
(1) Sequences which could not be assigned to the proximal or to the distal V-CLUSTER gene have been aligned with sequences of both genes. Both allele designation resulting from this alignment are given, separated by a dash, and mutation description is given by comparison to allele *01 of both genes.
Ex: Sequence Z00006 is designated as IGKV1-13*02/1D-13*02.
(2) An ORF sequence also exists for this V-REGION allele, due to a non-canonical heptamer.
(3) In EMBL, a new accession number M27751 was created, the original accession number X12688 becoming secondary accession number of M27751.

Created: 28/07/1997
Last updated: Wednesday, 12-Jun-2024 16:02:41 CEST
Author: Valérie Barbié
Editor: Chantal Ginestoux