Table of alleles: Human IGKV

Print of this table: Barbié, V. and Lefranc, M.-P., Exp. Clin. Immunogenet., 15, 171-183 (1998). PMID:9813414

The IMGT allele table refers to the V-REGION polymorphism. It does not include polymorphisms in the other parts of the V-GENE. V-REGION alleles are only described for genes which have at least one Functional or ORF allele. The accession number of a reference sequence is given for each allele.

Click on a gene name to get the alignment of the corresponding V-REGION alleles.
Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).

gene name
allele name
Accession number Confirmed
by genetics
and/or data
Description of mutations
1 IGKV1-5 F IGKV1-5*01 Z00001 +
c65  , T22  |g166  ,t168  ,D56  |c171  |c174  |g201  |
F IGKV1-5*02 M23851  
c65>t, T22>I|
F IGKV1-5*03 X72813  
IGKV1-6 F IGKV1-6*01 M64858 +  
IGKV1-8 F IGKV1-8*01 Z00014    
IGKV1D-8 F IGKV1D-8*01 Z00008 +  
IGKV1-9 F IGKV1-9*01 Z00013 +  
IGKV1-12 F IGKV1-12*01 V01577 +
            |c334  |
IGKV1D-12 F IGKV1D-12*01 X17263 +
t30  |t270  |c334  |
IGKV1-12/IGKV1D-12 (1) F IGKV1-12*02/1D-12*02 V01576  
	    |c334>t| (if IGKV1-12*02)

t30>c|t270>c|c334>t| (if IGKV1D-12*02)
IGKV1-13 P IGKV1-13*01 Z00010 +
a123  ,*41  |a326  ,N109  |
F IGKV1-13*02 Z00006  
IGKV1D-13 F IGKV1D-13*01 X17262  
            |a326  ,N109  |
IGKV1-16 F IGKV1-16*01 J00248  
g224  ,R75  |
[F] IGKV1-16*02 FM164406  
IGKV1D-16 F IGKV1D-16*01 K01323 +
t78  ,S26  |
F IGKV1D-16*02 V00558 +
IGKV1-17 F IGKV1-17*01 X72808 +
g278   ,S93   | 
F IGKV1-17*02 D88255  
g278>a ,S93>N |
IGKV1D-17 F IGKV1D-17*01 X63392  
a1  ,N1  |a155  ,H52  |
[F] IGKV1D-17*02 FM164407  
IGKV1-27 F IGKV1-27*01 X63398 +  
IGKV1-33 F IGKV1-33*01 M64856 +  
IGKV1D-33 F IGKV1D-33*01 M64855 +  
IGKV1-37 ORF IGKV1-37*01 X59316    
IGKV1D-37 ORF IGKV1D-37*01 X71893    
IGKV1-39 F IGKV1-39*01 X59315 +
c29  ,S10  |c306  |a315  |c316  ,a317  ,g318  ,Q106  |a319  ,S107  |c330  |
P IGKV1-39*02 X59318  
IGKV1D-39 F IGKV1D-39*01 X59312    
IGKV1D-42 ORF IGKV1D-42*01 X72816    
IGKV1D-43 F IGKV1D-43*01 X72817 +  
2 IGKV2-24 F IGKV2-24*01 X12684 +  
IGKV2D-24 ORF IGKV2D-24*01 X63401 +  
IGKV2-28 F IGKV2-28*01 X63397    
IGKV2D-28 F IGKV2D-28*01 X12691 +  
IGKV2-29 P IGKV2-29*01 X63396 +
g159  |a312  ,*104  |
F IGKV2-29*02 U41645  
F IGKV2-29*03 AJ783437  
IGKV2D-29 F IGKV2D-29*01 M31952 +
c145  ,P49  |
F(2) IGKV2D-29*02 U41644  
IGKV2-30 F IGKV2-30*01 X63403 +
t91  ,Y31  |
[F] IGKV2-30*02 FM164408  
IGKV2D-30 F IGKV2D-30*01 X63402 +  
IGKV2-40 F IGKV2-40*01 X59314  
c120  |g123  ,W41  |g233  ,G78  |
F IGKV2-40*02 X59317  
IGKV2D-40 F IGKV2D-40*01 X59311    
3 IGKV3-7 ORF IGKV3-7*01 X02725  
a118  ,T40  |t126  |c141  |g147  |a208  ,S70  |c571  ,T85  |c322  ,H108  |
ORF IGKV3-7*02 X72812  
a118>t,T40>S|t126>c|c141>g|g147>t|a208>g,S70>G|            |c322>t,H108>Y|
ORF IGKV3-7*03 K02769  
[ORF] IGKV3-7*04 FM164409  
IGKV3D-7 F IGKV3D-7*01 X72820 +  
IGKV3-11 F IGKV3-11*01 X01668 +
c568  ,T85  |
F IGKV3-11*02 K02768 +
IGKV3D-11 F IGKV3D-11*01 X17264 +  
IGKV3-15 F IGKV3-15*01 M23090 +  
IGKV3D-15 F IGKV3D-15*01 X72815 +
c14  ,T5  |g330  ,W110  |
P IGKV3D-15*02 M23091  
IGKV3-20 F IGKV3-20*01 X12686 +
g15  |g26  ,G9  |a221  ,c222  ,D74  |g303  |
F IGKV3-20*02 L37729  
IGKV3D-20 F IGKV3D-20*01 X12687 +  
4 IGKV4-1 F IGKV4-1*01 Z00023 +  
5 IGKV5-2 F IGKV5-2*01 X02485    
6 IGKV6-21 ORF IGKV6-21*01 X63399    
IGKV6D-21 ORF IGKV6D-21*01 X12683 +  
IGKV6D-41 ORF IGKV6D-41*01 M27751 (3) +  

IMGT notes:
(1) Sequences which could not be assigned to the proximal or to the distal V-CLUSTER gene have been aligned with sequences of both genes. Both allele designation resulting from this alignment are given, separated by a dash, and mutation description is given by comparison to allele *01 of both genes.
Ex: Sequence Z00006 is designated as IGKV1-13*02/1D-13*02.
(2) An ORF sequence also exists for this V-REGION allele, due to a non-canonical heptamer.
(3) In EMBL, a new accession number M27751 was created, the original accession number X12688 becoming secondary accession number of M27751.

Created: 28/07/1997
Last updated: Wednesday, 12-Jun-2024 16:02:41 CEST
Author: Valérie Barbié
Editor: Chantal Ginestoux