Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRAV

In this table are listed the rearranged complementary DNAs (cDNAs) and genomic DNAs (gDNAs) which are quoted in Arden, B. et al., Immunogenetics, 42, 455-500 (1995), or which represent potential new alleles without known germline sequences.

Rearranged cDNAs (#c) and gDNAs (#g) TRAV sequences have been assigned to IMGT TRAV genes and alleles as described in Germline gene tables, Alignments of alleles and Tables of alleles. Assignments were performed using IMGT/V-QUEST.

References are presented chronologically whenever possible.
Click here for correspondence between nomenclatures.

TRAV
gene name
Reference sequences
Rearranged cDNAs and gDNAs
CDR lengths
JUNCTION (11)
Allele name
Accession
number
Clone name
Accession numbers
1-1
TRAV1-1*01
AE000658 [52]
lambda S alpha 9
M12070 [6] #g
[6.2.x]
-
SUPT1
X03751 [9] p5'#g
[6.2.x]
-
 
M16746 [13] #g
[6.2.11]
+
 
D21847 [53] #c
[6.2.14]
+
TRAV1-1*02
X04939/M13731 #c
HAP21
X04939/M13731 [7] #c
[6.2.11]
+
 
L11161 [41] p3'°
[6.2.x]
 
1-2
TRAV1-2*01
AE000658 [52]
IGRa11
X58744 [22] #c
[6.2.x]
 
TRAV1-2*02
U32544 [46] p3'°
HAP12
X04938/M13732 [7] p3'#c
[6.2.x]
 
 
U32544 [46] p3'°
[6.2.x]
  
2
TRAV2*01
AE000658 [52]
HAP02
X04936/M13739 [7] #c
[6.0.11]
+
HAP29
X04941/M13741 [7] #c
[6.0.10]
+
HAP32
M13742 [7] #c
[6.0.10]
+
HAP28
X04952/M13740 [10] (1) °
[x.x.x]
 
 
U32522 [46] p3'°
[6.0.x]
 
TRAV2*02
M17659 #c
AB19
M17659 [10] #c
[6.0.11]
+
3
TRAV3*01
AE000658 [52]
AG21
M17651 [10] #c
[6.4.15]
+
 
U32525 [46] p3'°
[6.4.x]
 
TRAV3*02
M27377 #c
HAUT 32,35
M27377 [11] (2) #c
[6.4.14]
+
4
TRAV4*01
AE000658 [52]
AE212
M17663 [10] #c
[7.1.12]
+
 
U32529 [46] p3'°
[7.x.x]
 
5
TRAV5*01
AE000659 [52]
HAVT31
M27376 [11] #c
[6.3.10]
+
 
S60795 [26] #c
[6.3.14]
+
DE 49a110
Z22965 [39] p5'#c
[x.3.11]
+
2 DLE
M90482 [31] p5'#c
[x.3.12]
+
lambda P13
X05771 [14] (3) p5'#g
[x.3.11]
+
6
TRAV6*02
X58747 #c
IGRa10
X58747 [22] #c
[6.3.x]
 
WADM06D
D13069 [32] p3'#c
[6.3.x]
 
HAP35
X04953/M13729 [7] p5'#c
[6.3.13]
+
TRAV6*03
Z49060 p5'°
  
Z49060 [43] p5'°
[6.3.x]
 
TRAV6*04
Y10409 p5'°
  
Y10409 [48] p5'°
[6.3.x]
 
TRAV6*05
Y10410 p5'°
  
Y10410 [48] p5'°
[6.3.x]
 
TRAV6*06
U32542 [46] p3'°
  
U32542 [46] p3'°
[6.3.x]
 
8-1
TRAV8-1*01
AE000659 [52]
HAP10
X04949 [7] #c
[6.4.10]
+
TRAV8-1*02
U32520 [46] p3'°
HAP60
M13723 [7] p3'#c
[6.x.x]
 
 
U32520 [46] p3'°
[6.4.x]
 
8-2
TRAV8-2*02
M17650 #c
AE24A
M17650 [10] #c
[6.4.11]
+
8-3
TRAV8-3*01
AE000659 [52]
AE11
M17668 [10] (4) p5'#c
[x.x.10]
+
TRAV8-3*02
M35617 #g
lambdaR10
M35617 [15] #g
[6.4.10]
+
IGRa08
X58769 [22] p3'#c
[6.4.x]
 
TRAV8-3*03
L06885 #c
  
L06885 [33] #c
[6.4.x]
 
8-4
TRAV8-4*01
AE000659 [52]
AB22
M17646 [10] #c
[6.4.10]
+
 
X02592/M12959 [2] #c
[6.4.15]
+
TRAV8-4*02
M12423 #c
pY14
M12423 [3] #c
[6.4.15]
+
HAVT18
M27368 [11] #c
[6.4.15]
+
TRAV8-4*03
D13077 #c
WADM31F
D13077 [32] #c
[6.4.x]
 
AB18
M17647 [10] (5) #c
[6.4.12]
+
TRAV8-4*04
M12959 #c
pJM3E11
M12959 [2] #c
[6.4.15]
+
AA27
M17666 [10] p5'#c
[x.x.12]
+
TRAV8-4*05
X63455 #c
UB alpha14/4
X63455 [27] #c
[6.4.13]
+
TRAV8-4*06
K02777 p5'#c
pH alphaT3
K02777 [4] p5'#c
[6.4.15]
+
TRAV8-4*07
M17665 p5'#c
AP511
M17665 [10] p5'#c
[x.4.x]
+ (12)
8-6
TRAV8-6*01
X02850 [5]
lambda A87
J03597 [47] p5'#g
[x.x.13]
-
TRAV8-6*02
AE000659 [52]
WADM07B
D13070 [32] #c
[6.4.x]
 
 
M86361 [28] #c
[6.4.14]
+
40
M87871 [31] p5'#c
[x.4.17]
+
28
M87869 [31] p5'#c
[x.4.11]
+
 
Z26593 [45] #c
[6.4.11]
+
AA17
M17649 [10] (6)#c
[6.4.12]
+
9-2
TRAV9-2*01
AE000659 [52]
WADM13D
D13072 [32] #c
[6.3.12]
+
TRAV9-2*02
X58745 #c
IGRa22
X58745 [22] #c
[6.3.x]
 
AC9
M17671 [10] p5'#c
[x.x.13]
+
AL61.270
M97706 [35] #c
[6.3.13]
+
 
U32530 [46] p3'°
[6.3.x]
 
TRAV9-2*03
L06881 #c
  
L06881 [33] #c
[6.3.x]
 
TRAV9-2*04
L06882 #c
  
L06882 [33] #c
[6.3.x]
 
10
TRAV10*01
AE000659 [52]
IGRa02
X58737 [22] #c
[6.3.x]
 
lambda L3
X05770 [14] p5'#g
[x.3.13]
+
 
U32532 [46]p3'°
[6.3.x]
 
12-1
TRAV12-1*01
AE000659 [52]
WADM31J
D13078 [32] #c
[6.2.x]
 
TRAV12-1*02
M17657 #c
AA25
M17657 [10] #c
[6.2.12]
+
12-2
TRAV12-2*01
AE000659 [52]
HAVT06
M27369 [11] (7) #c
[x.2.14]
+
TRAV12-2*02
M81774 #c
8B3
M81774 [21] #c
[6.2.12]
+
IGRa09
X58746 [22] #c
[6.2.x]
 
AF110
M17652 [10] #c
[6.2.13]
+
AC112
M17653 [10] #c
[6.2.10]
+
A13ct7
S60781 [37] (8) p3'#c
[6.x.x]
 
 
L11159 [41] p3'°
[6.2.x]
-
TRAV12-2*03
X04946/M13725 #c
HAP71
X04946/M13725 [7] #c
[6.2.14]
+
HAP26
X04940/M13724 [7] #c
[6.2.9]
+
12-3
TRAV12-3*01
X06193 [12]
AG110
M17655 [10] #c
[6.2.13]
+
AA13
M17654 [10] #c
[6.2.12]
+
 
U32538 [46] p3'°
[6.2.x]
 
TRAV12-3*02
M17656 #c
AC17
M17656 [10] #c
[6.2.11]
+
 
M17669 [10] p5'#c
[6.2.12]
+
13-1
TRAV13-1*01
AE000659 [52]
WADM35A
D13079 [32] #c
[6.3.x]
 
TRAV13-1*02
X04954/M13733 #c
HAP41
X04954/M13733 [7] #c
[6.3.14]
+
S14.4
M97714 [35] #c
[6.3.13]
+
HAP17
X04950/M13734 [7] #c
[6.3.13]
+
HAP49
X04944/M13735 [7] #c
[6.3.14]
+
TRAV13-1*03
L11162 °
 
L11162 [41] p3'°
[6.3.x]
 
13-2
TRAV13-2*01
AE000659 [52]
HAVT24
M27373 [11] #c
[6.3.11]
+
HAP50
X04956 [7] #c
[6.3.9]
+
 
U32545 [46] p3'°
[6.3.x]
 
TRAV13-2*02
M17658 #c
AG212
M17658 [10] #c
[6.3.12]
+
14
TRAV14/DV4*02
AE000659 [52]
17A2
M87870 [31] p5'#c
[x.4.11]
+
 
S51029 [29] #c
[7.4.x]
 
TTC-A-5
Z14996 [42] #c
[7.4.11]
+
 
L06884 [33] #c
[7.4.x]
 
HAP01
X04947/M13730 [7] (9) #c
[7.4.11]
+
TRAV14/DV4*03
M21624 #c
DS6
M21624 [16] #c
[7.4.11]
+
TRAV14/DV4*04
L09758 °
 
L09758 [34] °
[7.4.x]
 
16
TRAV16*01
AE000659 [52]
HAP36
X04942/M13737 [7] #c
[6.0.12]
+
 
M90479 [31] p5'#c
[6.0.x]
-
 
U32546 [46] p3'°
[6.0.x]
 
17
TRAV17*01
AE000660 [52]
HAP44
X04955/M13727 [7] #c
[5.3.15]
+
HAP05
X04948/M13726 [7] #c
[5.3.11]
+
 
U32540 [46] p3'°
[5.3.x]
 
19
TRAV19*01
AE000660 [52]
E4
Z46641 [44] (10) #g
[7.4.22]
+
64.8P
M87866 [31] p5'#c
[7.4.13]
+
AC5
M17670 [10] p5'#c
[x.x.13]
+
pGA-5
X01403 [1] #c
[7.4.10]
+
HTA73
X70310 [50] #c
[7.4.x]
 
20
TRAV20*02
X68696 #c
  
X68696 [36] #c
[6.3.x]
 
A17ct3
D16586 [37] #c
[6.3.x]
 
S14.11
M97712 [35] #c
[6.3.13]
+
TRAV20*03
S60789 #c
A17ct3
S60789 [37] #c
[6.3.x]
 
139DRD
M87865 [31] p5'#c
[6.3.12]
+
TRAV20*04
X70305 #c
HTA129
X70305 [50] #c
[6.3.x]
 
21
TRAV21*02
X58736 #c
IGRa01
X58736 [22] #c
[6.3.x]
 
22
TRAV22*01
AE000660 [52]
HAVT15
M27374 [11] #c
[5.1.13]
+
S26.2
M97722 [35] #c
[5.1.10]
+
23
TRAV23/DV6*01
AE000660 [52]
K15A
M22936 [17] p5'#g
[x.3.11]
+
HTA61
X70309 [50] #c
[6.3.x]
 
RFL3.8a
M77498 [49] #c
[6.3.11]
+
 
U32526 [46] p3'#°
[6.3.x]
 
TRAV23/DV6*02
M17660 #c
AB11
M17660 [10] #c
[6.3.12]
+
K15A
M22936 [17] p5'#g
[x.3.11]
 
WADM11H
D13071 [32] p3'#c
[6.3.x]
 
TRAV23/DV6*03
M97704 #c
AL61.102
M97704 [35] #c
[6.3.9]
+
 
Z49057 [43] °
[6.3.x]
 
TRAV23/DV6*04
Y10411 °
  
Y10411 [48] °
[6.3.x]
 
24
TRAV24*02
M17661 #c
AB21
M17661 [10]#c
[6.3.15]
+
25
TRAV25*01
AE000660 [52]
WADM15B
D13073 [32] #c
[5.3.x]
 
HTA286
X70307 [50] #c
[5.3.x]
 
 
X68698 [36] #c
[5.3.x]
 
KT2
M64350 [30] #c
[5.3.x]
+
NA20
S50881 [29] #c
[5.3.x]
 
26-1
TRAV26-1*01
AE000660 [52]
HAVT33
M27370 [11] #c
[7.1.14]
+
A-55
M18460 [18] #c
[7.1.13]
+
TRAV26-1*02
M27371 #c
HAVT27
M27371 [11] #c
[7.1.14]
+
HAVT01
M27372 [11] #c
[7.1.13]
+
 
U32541 [46] p3'°
[7.1.x]
 
TRAV26-1*03
L06886 #c
  
L06886 [33] #c
[7.1.x]
 
26-2
TRAV26-2*01
AE000660 [52]
HAP08
X04937/M13728 [7] #c
[7.1.14]
+
AS1
L29035 [54] #c
[7.1.14]
+
DD1
L26451 [54] #c
[7.1.14]
+
TRAV26-2*02
L11160 p3'°
  
L11160 [41] p3'°
[7.1.x]
 
27
TRAV27*01
AE000660 [52]
  
U32521 [46] p3'#°
[5.3.x]
 
 
L09760 [34] °
[5.3.x]
 
22DAG
M87868 [31] p5'#c
[x.3.10]
+
TRAV27*02
X04957 #c
HAP58
X04957 [7] #c
[5.3.12]
+
TRAV27*03
D13075 #c
WADM22B
D13075 [32] #c
[5.3.x]
 
 
L09759 [34] °
[5.3.x]
 
 
U32521 [46] p3'°
[5.3.x]
 
29
TRAV29/DV5*01
AE000660 [52]
DE5a18
Z23047 [39] #c
[6.3.10]
+
WADM24B
D13076 [32] #c
[6.3.x]
 
KT08A
X14548 [20] #c
[6.3.21]
+
L17Ti-d
M15565 [8] #c
[6.3.12]
+
TRAV29/DV5*02
S81645 #c
  
S81645 [23] #c
[6.3.x]
-
AF211
M17664 [10] (13) #c
[6.3.14]
+
30
TRAV30*01
AE000660 [52]
E5
Z46642 [44](16)#g
[5.3.x]
 
MT-ALL
S63879 [24] #g
[5.3.11]
+
TRAV30*02
X58768 #c
IGRa07
X58768 [22] #c
[5.3.x]
 
TRAV30*03
L06883 #c
  
L06883 [33] #c
[5.3.x]
 
TRAV30*04
U32537 [46] p3'°
  
U32537 [46] p3'°
[5.3.x]
 
34
TRAV34*01
AE000660 [52]
IGRa04
X58739 [22] #c
[5.3.x]
 
 
U32534 [46] °
[5.3.x]
 
35
TRAV35*02
X58738 #c
IGRa03
X58738 [22] #c
[5.3.x]
 
 
U32533 [46] p3'#°
[5.3.x]
 
36
TRAV36/DV7*02
X61070 #c
  
X61070 [22] #c
[6.3.12]
+
TRAV36/DV7*03
X58767 #c
IGRa06
X58767 [22] #c
[6.3.x]
 
TRAV36/DV7*04
Z46643 #c
E2
Z46643 [44] #c
[6.3.11]
+
 
U32536 [46] p3'#°
[6.3.x]
 
38-1
TRAV38-1*01
AE000661 [52]
WADM20F
D13074 [32] #c
[7.4.x]
 
 
X58157 [25] (14) #g
[7.4.x]
 
TRAV38-1*02
M64355 #c
AL4.1
M64355 [30] #c
[7.4.11]
+
TRAV38-1*03
M95394 #c
  
M95394 [51] #c
[7.4.18]
+
TRAV38-1*04
L06880 #c
  
L06880 [33] #c
[7.4.x]
 
38-2
TRAV38-2/DV8*01
AE000661 [52]
115E15
Z29614 [40] #c
[7.4.13]
+
E6
Z46644 [44] (15) #g
[7.4.23]
+
HAVT20
M27375 [11] #c
[7.4.11]
+
lambda
X58158 [25] p3'#g
[7.x.x]
 
 
U32524 [46] p3'°
[7.4.x]
 
39
TRAV39*01
AE000661 [52]
IGRa03
X58740 [22] #c
[5.3.x]
 
H
M23431 [19] p5'#g
[x.3.12]
+
40
TRAV40*01
X73521 [38]
 
X68697/S59347 [36] #c
[6.0.x]
 
 
X70306 [50] #c
[6.0.x]
 
A32ct7
S60792/D16585 [37] #c
[6.0.x]
 
41
TRAV41*01
AE000661 [52]
AC24
M17662/J02992 [10] #c
[5.1.12]
+
S30.1
M97724 [35] #c
[5.1.11]
+
 
U32528 [46] p3'°
[5.1.x]
 
p3' : partial in 3' ; p5' : partial in 5' (more than 10 amino acids missing in 5')
# : rearranged ; #c : rearranged cDNA ; #g : rearranged genomic DNA.
° : DNA genomic sequence, but not known as being germline or rearranged.

IMGT notes:
(1) Leader spliced to a truncated TRAV2 rearranged to TRAJ31*01. Only eight amino acids from the 3' end of the V-REGION are present.
(2) The nucleotide g inserted at position 20 (20^21 >ins^g, according to the IMGT numbering) probably results from a sequencing or typing error.
(3) Two mutations in FR3-IMGT (t239>g, g240>t, L80>C, according to the IMGT numbering) and an INSERTION in CDR3-IMGT are probably typing or sequencing errors.
(4) Mutation of the first nucleotide of this sequence (a209>g, according to the IMGT numbering) is probably a sequencing error.
(5) Mutations in the CDR1-IMGT (c80>g, g81>c, S27>C, according to the IMGT numbering) are probably sequencing or typing errors.
(6) Because of several sequencing or typing errors in FR3-IMGT (DELETION of nucleotide a at position 221, and INSERTION of a nucleotide a between position 253 and 254, according to the IMGT numbering) , the mutation observed in FR1-IMGT (t42>g, F14>C, according to the IMGT numbering) does not allow to define a new allele.
(7) DELETION of nucleotide g in CDR1-IMGT (g86>del#, according to the IMGT numbering) is probably due to a sequencing or typing error.
(8) A mutation in CDR1-IMGT (g86>t, G28>V, according to the IMGT numbering) may represent a polymorphic nucleotide. However, the sequence is partial and cannot define a new allele.
(9) X04947/M13730 presents several sequencing errors in FR2-IMGT, CDR2-IMGT and FR3-IMGT by nucleotide DELETION and INSERTION.
(10) In this sequence, the TRAV19 gene is rearranged to (D)J segment of the TRD locus. However the authors could not test their expression on the cell surface and did not give them a DV nomenclature.[44]
(11) + indicates in-frame JUNCTION, - indicates out-of-frame JUNCTION, a blank indicates not defined JUNCTION.
(12) The JUNCTION is in-frame, with a STOP-CODON.
(13) Several mutations are observed in FR3-IMGT. They are probably typing or sequencing errors.
(14) Three INSERTIONs of nucleotide in FR3-IMGT are probably typing errors .
(15) In this sequence, the TRAV38-2 gene is rearranged to (D)J segment of the TRD locus.
(16) In this sequence, the TRAV30 gene is rearranged to (D)J segment of the TRD locus. However the authors could not test their expression on the cell surface and did not give them a DV nomenclature.[44]

IMGT references:
[1]
 Sim, G. K. et al., Nature, 312, 771-775 (1984).
[2]
 Rabbitts, T.H. et al., EMBO J., 4, 1461-1465 (1985).
[3]
 Yanagi, Y. et al., Proc. Natl. Acad. Sci. USA, 82, 3430-3434 (1985).
[4]
 Croce, C.M. et al., Science, 227, 1044-1047 (1985).
[5]
 Yoshikai, Y. et al., Nature, 316, 837-840 (1985).
[6]
 Baer, R. et al., Cell, 43, 705-713 (1985).
[7]
 Yoshikai, Y. et al., J. Exp. Med., 164, 90-103 (1986).
[8]
 Leiden, J.M. et al., Immunogenetics, 24, 17-23 (1986).
[9]
 Denny, C.T. et al., Nature, 320, 549-551 (1986).
[10]
 Klein, M.H. et al., Proc. Natl. Acad. Sci. USA, 84, 6884-6888 (1987).
[11]
 Kimura, N. et al., Eur. J. Immunol., 17, 375-383 (1987).
[12]
 Luria, S. et al., EMBO J., 6, 3307-3312 (1987).
[13]
 Baer, R. et al., Cell, 50, 97-105 (1987).
[14]
 Mengle-Gaw, L. et al., EMBO J., 6, 2273-2280 (1987).
[15]
 Baer, R. et al., EMBO J., 7, 1661-1668 (1988).
[16]
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Created: 02/02/2001
Authors: Franç°oise Marlhens and Dominique Scaviner