In this table are listed representative rearranged complementary DNAs (cDNAs) and genomic DNAs (gDNAs).
Rearranged cDNAs (#c) and gDNAs (#g) TRAV sequences have been assigned to IMGT TRAV genes and alleles as described in Germline gene tables, Alignments of alleles and Tables of alleles. Assignments were performed using IMGT/V-QUEST.
gene name |
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number |
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M73265 #c | DF6 | A/J | M73265 [48]#c | [5.4.x] | n.d. | ||
M87844 #g | BO4H9.1 | C57BL/6 | M87844 [52]#g | [5.4.11] | + | ||
BO3H-25 | C57BL/6 | M87846 [52]#c | [5.4.11] | + | |||
S81113 #c | 231F1 | S81113 [83]#c | [5.4.12] | + | |||
U63776 #g | V11PCC-19 | B10.A | U63776 [84](3)#g | [5.4.x] | |||
X02968 #c | 2B4 | B10.A | X02968 [3]#c | [5.4.13] | + | ||
M87848 #c | bm2T3.1 | C57BL/6 | M87848 [52]#c | [5.4.12] | + | ||
M27351 #c | NA3(V2B4) | BALB/c nu/nu | M27351 [10]#c | [5.4.12] | + | ||
AC004102 | G8 | BALB/c nu/nu | X14095 [24]p5'#c | [x.4.19] | + | ||
AF259071 | pXTL63 | C57BL/10 | D16596 [64](5)p5'#c | [x.x.14] | + | ||
AC005855 | BALB/c | M38681 [23]#c | [6.6.x] | ||||
U07877 #c | L-3A | SWR x NZB (F1) | U07877 [67]#c | [6.6.x] | |||
U07876 #c | H16G10 | SWR x NZB (F1) | U07876 [67]p5'#c | [6.6.x] | |||
U80816 #c | H-2I-A | NOD | U80816 [89]#c | [6.6.10] | + | ||
AC003995 | BALB/c | AJ311367 [23](6)p3'#c | [6.6.x] | ||||
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TRAV15D-2/DV6D-2 | TRDV15D-2/DV6D-2*01 | AC005402 | Z53 | BALB/c x 129 (F1) | M37285 [29]#c | [7.4.15] | + |
DB.2 | DBA/2 | AF085007 [107]#c | [7.4.x] | ||||
TRAV15D-2/DV6D-2*02 | AJ271435 #c | 2B4 | B10.A | AJ271435 [106]#c | [7.4.x] | - | |
TRAV15D-2/DV6D-2*03 | AF085009 #c | B.1 | C57BL/6 | AF085009 [107]#c | [7.4.x] | ||
TRAV15D-2/DV6D-2*04 | AF085006 #c | DB.1 | DBA/2 | AF085006 [107]#c | [7.4.x] | ||
TRAV15D-2/DV6D-2*05 | AF085008 #c | DB.3 | DBA/2 | AF085008 [107]#c | [7.4.x] | ||
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TRAV15-2/DV6-2 | TRAV15-2/DV6-2*01 | AC003997 | Z49 | BALB/c x 129 (F1) | M37287 [29]#g | [7.4.x] | - |
Z80 | BALB/c x 129 (F1) | M37286 [29](18) #c | [7.x.x] | - | |||
Y245 | C3H/HeN | S90647 [105]#c | [7.4.x] | ||||
Z49 | C3H/HeN | S90650 [105]#c | [7.4.15] | + | |||
TRAV15-2/DV6-2*02 | AF085010 #c | B.2 | C57BL/6 | AF085010 [107]#c | [7.4.x] | ||
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IMGT notes:
(1) | + indicates in-frame JUNCTION, - indicates out-of-frame JUNCTION, n.d. indicates not defined JUNCTION (for example for partial sequences), a blank indicates that the information is not relevant (germline gene). |
(2) | Pseudogene because DELETIONs of 4 nucleotides at positions 32, 54, 69 in FR1-IMGT and 89 in CDR1-IMGT. |
(3) | Between positions 293 and 294, there is an INSERTION of 12 nucleotides (cccagctggagg) which is a duplication of positions 280-293 (Bosc, N., IMGT comment, 28/08/2001.). This INSERTION may represent a sequencing error. |
(4) | The sequence U63774 is probably a TRAV4D-4*02 allele. However there is an DUPLICATION of 12 nucleotides (cccagctggagg) between positions 292 and 293. This INSERTION may represent a sequencing error. |
(5) | The allele designation was not attributed because it is not possible to determine if the nucleotide differences represent a new polymorphism or typing errors. |
(6) | V-REGION is partial: AA 97 to 107 are missing (partial FR3-IMGT and no CDR3-IMGT). |
(7) | Mutations in FR3-IMGT (a246>g; a247>g, g248>a, R83>E; a250>c, c251>a, T84>Q, according to the IMGT unique numbering) are probably sequencing or typing errors. |
(8) | Mutations in FR3-IMGT (a285>g; g288>a, according to the IMGT unique numbering) are probably sequencing or typing errors. |
(9) | Pseudogene because DELETION of one nucleotide at position 83 in CDR2-IMGT. |
(10) | Mutations in FR2-IMGT (g140>t, c141>a, G47>V; a142>g, K48>E; g145>a, G49>S according to the IMGT numbering) are probably sequencing or typing errors. |
(11) | Pseudogene because DELETION of one nucleotide at position 299 in codon 100 leading to a frameshift in FR3-IMGT. |
(12) | Pseudogene because DELETION of 3 nucleotides (a279-g281>del(3nt)#) leading to a frameshift in FR3-IMGT. |
(13) | X63929, M22659, M98567 and U21417 sequences being partial, it is not possible to decide if these genes belong to the allele *02, *04 or *05. |
(14) | AF034161 sequence being partial, it is not possible to decide if the gene belongs to the allele *01, *03 or *04. |
(15) | M34214 sequence being partial, it is not possible to decide if the gene belongs to the allele *01 or *03. |
(16) | X02971 and X04046 sequences being partial, it is not possible to decide if these genes belong to the allele *01 or *02. |
(17) | M98571 and M98572 sequences being partial, it is not possible to decide if these genes belong to the allele *01 or *05. |
(18) | M37286 has a deletion of 134 nucleotides compared to the IMGT reference sequence TRAV15-2/DV6-2 (M37287). It is not known if these differences result from a cloning artefact and/or typing or sequencing error. |
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Created: 05/09/2001
Last updated: Friday, 22-Sep-2023 18:31:11 CEST
Author: Nathalie Bosc