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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHV1 IGHV1S1 IGHV1S1*01 F VH1 Y00380 [1]
IGHV1S2 IGHV1S2*01 (F) + + M24673 [2] #c
IGHV1S3 IGHV1S3*01 (F) + + VHg44A M94850 [3] #c
IGHV1S4 IGHV1S4*01 (F) + + M30024 [4] #c
IGHV1S5 IGHV1S5*01 (F) + + VHg21 M94841 [3] #c
IGHV1S6 IGHV1S6*01 (F) + + VHg27 M94854 [3] #c
IGHV1S7 IGHV1S7*01 (F) + + VHg10B M94840 [3] #c
IGHV1S8 IGHV1S8*01 (F) + + VHg346B M94845 [3] #c
IGHV1S9 IGHV1S9*01 (F) + + VHg7B M94853 [3] #c
IGHV1S10 IGHV1S10*01 (F) + + VHg341 M94843 [3] #c
IGHV1S11 IGHV1S11*01 (F) + + VHg4B M94851 [3] #c
IGHV1S12 IGHV1S12*01 (F) + + VHg10A M94839 [3] #c
IGHV1S13 IGHV1S13*01 (F) + + VHg343 M94844 [3] #c
IGHV1S14 IGHV1S14*01 (F) + + VHg349B M94847 [3] #c
IGHV1S15 IGHV1S15*01 (F) + + VHg352 M94849 [3] #c
IGHV1S16 IGHV1S16*01 (F) + + VHg2B M94842 [3] #c
IGHV1S17 IGHV1S17*01 (F) + + VHg35 M94848 [3] #c
IGHV1S18 IGHV1S18*01 (F) + + VHg349A M94846 [3] #c
IGHV1S19 IGHV1S19*01 (F) + + VHg5 M94852 [3] (1) #c
IGHV1S20 IGHV1S20*01 (F) + + M30026 [4] (2) #c
IGHV2 IGHV2S1 IGHV2S1*01 (F) + + VH2 M24674 [2] (3) #c
IGHV2S2 IGHV2S2*01 (F) + + M30025 [4] (3) #c
IGHV2S3 IGHV2S3*01 (F) + + M30027 [4] (3) #c
IGHV2S4 IGHV2S4*01 (F) + + M30028 [4] (3) #c
IGHV2S5 IGHV2S5*01 (F) + + M30029 [4] (3) #c
IGHV2S6 IGHV2S6*01 (F) + + M30030 [4] (3) #c
IGHV3 IGHV3S1 IGHV3S1*01 (F) + + VH3 M24675 [2] #c
IGHV3S2 IGHV3S2*01 (F) + + M30031 [4] #c
IGHV3S3 IGHV3S3*01 (F) + + M30032 [4] (4) #c
IGHV3S4 IGHV3S4*01 (F) + + M30033 [4] (5) #c
IGHV4 IGHV4S1 IGHV4S1*01 (F) + + VH4 M24676 [2] (3) #c
IGHV5 IGHV5S1 IGHV5S1*01 (F) + + VH5 M24677 [2] #c
IGHV6 IGHV6S1 IGHV6S1*01 (F) + + VH6 M24678 [2] #c
IGHV7 IGHV7S1 IGHV7S1*01 (F) + + VH7 M24679 [2] (10) #c
IGHV8 IGHV8S1 IGHV8S1*01 (F) + + VH8 M24680 [2] #c
IGHV8S2 IGHV8S2*01 (F) + + M30034 [4] (6) #c
IGHV8S3 IGHV8S3*01 (F) + + M30035 [4] (7) #c
IGHV9 IGHV9S1 IGHV9S1*01 (F) + + VH9 M24681 [2] #c
IGHV9S2 IGHV9S2*01 (F) + + M30036 [4] #c
IGHV10 IGHV10S1 IGHV10S1*01 (F) + + VH10 M27254 [5] (1,8) #c
IGHV11 IGHV11S1 IGHV11S1*01 (F) + + VH11 M27255 [5] (9) #c

#c: rearranged cDNA

IMGT notes:
  1. (1) V-REGION is partial in 3': AA 77 to 104 are missing (partial FR3-IMGT).
  2. (2) V-REGION is partial in 5': AA 1 to 52 are missing (partial FR2-IMGT).
  3. (3) V-REGION is partial in 5': partial FR1-IMGT.
  4. (4) V-REGION is partial in 5': AA 1 to 69 are missing (partial FR1-IMGT, CDR1-IMGT, FR2-IMGT, CDR2-IMGT and FR3-IMGT).
  5. (5) V-REGION is partial in 5': AA 1 to 76 are missing (partial FR1-IMGT, CDR1-IMGT, FR2-IMGT, CDR2-IMGT and FR3-IMGT).
  6. (6) V-REGION is partial in 5': AA 1 to 38 are missing (partial FR1-IMGT, CDR1-IMGT).
  7. (7) V-REGION is partial in 5': AA 1 to 81 are missing (partial FR1-IMGT, CDR1-IMGT, FR2-IMGT, CDR2-IMGT and FR3-IMGT).
  8. (8) V-REGION is partial in 5': AA 1 to 43 are missing (partial FR1-IMGT, CDR1-IMGT, FR2-IMGT).
  9. (9) V-REGION is partial in 5': AA 1 to 20 are missing (partial FR1-IMGT).
  10. (10) The CONSERVED-TRP is replaced by HIS.
IMGT references:
  1. [1] Yamawaki-Kataoka Y. and Honjo, T., Nucleic Acid Res., 15, 5888-5888 (1987). PMID:3112743
  2. [2] Haire R.N., Unpublished.
  3. [3] Wilson M. et al., EMBO J., 11, 4337-4347 (1992). PMID:1425571
  4. [4] Hsu E. et al., Proc. Natl. Acad. Sci., USA, 86, 8010-8014 (1989). PMID:2510156
  5. [5] Haire R.N. et al., J. Exp. Med., 171, 1721-1737 (1989). PMID:2110243
Created:
17/07/2003
Last updated:
22/09/2023
Authors:
Delphine Guiraudou