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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHM1 IGHM1*01 (F) Cp1 CH1 (1) AB004105 [1] c (s) CpM AB004106 [1] c (m)
CH2 AB004105 [1] c (s) CpM AB004106 [1] c (m)
CH3 (2) AB004105 [1] c (s) CpM AB004106 [1] c (m)
CH4 (2) AB004105 [1] c (s)
CpM M1 (2) AB004106 [1] c (m)
M2 AB004106 [1] c (m)
IGHM1*02 (F) Cp3 CH1 (1) AB004107 [1] c (s)
CH2 AB004107 [1] c (s)
CH3 (2) AB004107 [1] c (s)
CH4 (2) AB004107 [1] (3) c (s)
M1 (2)
M2
IGHM2 IGHM2*01 (F) Cp4 CH1 (1) AB004108 [1] c (s)
CH2 AB004108 [1] c (s)
CH3 (2) AB004108 [1] c (s)
CH4 (2) AB004108 [1] (3) c (s)
M1 (2)
M2

c: cDNA sequence.
(s) Transcript of a secreted chain.
(m) Transcript of a membrane chain.

IMGT notes:
  1. (1) The last ten amino acids of CH1, rich in prolin, suggest the existence of a region with hinge-like characteristics.
  2. (2) CH3 is spliced to CH4 in secretory mu cDNA, whereas it is spliced to the M1 exon in membrane mu cDNA.
  3. (3) Partial C-REGION: CH4 is partial in 3'.
IMGT references:
  1. [1] Nakao M. et al., Fish and Shellfish Immunol., 8, 425-434 (1998). doi:10.1006/fsim.1998.0149
Created:
29/04/1999
Last updated:
09/01/2013
Authors:
Sylvaine Artero