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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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The Horn shark (Heterodontus francisci) IGIV genes and alleles have a temporary designation based on the IMGT gene name nomenclature rules for the unmapped genes, the incomplete loci, or the cDNAs in the absence of germline genes.

IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGIV1 IGIV1S1 IGIV1S1*01 F λ141 X15315 [1]
IGIV1S2 IGIV1S2*01 F λ122 X15316 [1]
IGIV1S3 IGIV1S3*01 (F) + + 1501 M24368 [2] #c
IGIV1S4 IGIV1S4*01 (F) + + 1301 M64307 [2] #c
IGIV2 IGIV2S1 IGIV2S1*01 (F) + + HfrK4 L25561 [3] #c
IGIV2S2 IGIV2S2*01 (F) + + HfrK5 L25562 [3] #c
IGIV2S3 IGIV2S3*01 (F) + + HfrK6 L25563 [3] #c
IGIV3 IGIV3S1 IGIV3S1*01 (F) + + Hfr1A1 L25558 [3] ~VJ
IGIV3S2 IGIV3S2*01 (F) + + Hfr1B1 L25560 [3] ~VJ

#c: rearranged cDNA.
~VJ: VJ genomic DNA rearranged in the cassette.

IMGT references:
  1. [1] Shamblott M.J. et al., EMBO J., 8, 3733-3739 (1989). PMID:2511000
  2. [2] Shamblott M.J. et al., Proc. Natl. Acad. Sci. USA, 86, 4684-4688 (1989). PMID:2499889
  3. [3] Rast J.P. et al., Immunogenetics, 40, 83-99 (1994). PMID:8026868
Created:
25/09/2003
Last updated:
29/06/2011
Authors:
Dominique Scaviner