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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHV3 (3) IGHV3S1 IGHV3S1*01 F VHH1 AF305944 [1]
IGHV3S2 IGHV3S2*01 F VHH2 AF305945 [1]
IGHV3S3 IGHV3S3*01 F VHH3 AF305946 [1]
IGHV3S4 IGHV3S4*01 F VHH4 AF305947 [1]
IGHV3S5 IGHV3S5*01 F VHH5 AF305948 [1]
IGHV3S6 IGHV3S6*01 F VH1 AF305949 [1]
IGHV3S7 IGHV3S7*01 P (1) Vpseudo1 AF305950 [1]
IGHV3S8 IGHV3S8*01 P (2) Vpseudo2 AF305951 [1]
IMGT notes:
  1. (1) In frame STOP-CODON (positions 127-129) at codon 43 in FR2-IMGT.
  2. (2) In frame STOP-CODON (positions 307-309) at codon 103 in FR3-IMGT.
  3. (3) Previously annotaded as IGHV1 subgroup.The Llama (Lama glama) IGHV3 genes belong, as those of the Arabian camel (Camelus dromedarius) IGHV3 genes, to two sets based on amino acid sequences and, probably on the presence or lack of light chain in the antibodies. The functional IGHV3S6 gene and the IGHV3S7 and IGHV3S8 pseudogenes belong to the first set. The functional IGHV3S1 to IGHV3S5 genes belong to the second set. Four FR2-IMGT positions (42, 49, 50 and 52 in the IMGT unique numbering) show amino acid differences characteristic of each set:
    FR2-IMGT amino acid positions 42 49 50 52
    IGHV3S6, IGHV3S7(P), IGHV3S8(P) V G L W
    IGHV3S1 to IGHV3S5 F,Y E R G,L,W
IMGT references:
  1. [1] Woolven B.P. et al., Unpublished.
Last updated:
Joumana Jabado-Michaloud, Dominique Scaviner