IMGT Repertoire (IG and TR)

Fct: FUNCTIONALITY
- F: Functional
- P: Pseudogene
- ORF: Open Reading Frame
T: Transcribed
Pr: Translated into protein

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name to get the corresponding IMGT/GENE-DB entry,
IMGT allele name to see the corresponding Alignments of alleles,
accession number to get the corresponding IMGT/LIGM-DB entry.

IMGT gene name	IMGT allele name		Fct	T	Pr	Positions in the locus	IMGT/LIGM-DB reference sequences						IMGT/LIGM-DB sequences from the literature
IMGT gene name	IMGT allele name		Fct	T	Pr	Positions in the locus	Strain	Clone names	Exons	Accession numbers	Positions in the sequence	Secondary accession numbers	Strain	Clone names	Accession numbers				Positions in the sequence
	IGHM		IGHM*01	(F)								CH1			AF437724	[1]	(1)	c(s)
												CH2			AF437724	[1]		c(s)
												CH3			AF437724	[1]		c(s)
												CH4 (including CHS )			AF437724	[1]		c(s)
												M1
												M2
			IGHM*02	(F)								CH1			AF437725	[1]	(1)	c(s)		AF437735	[1]	(2)	c(m)
												CH2			AF437725	[1]		c(s)		AF437735	[1]		c(m)
												CH3			AF437725	[1]		c(s)		AF437735	[1]		c(m)
												CH4 (including CHS)			AF437725	[1]		c(s)		AF437735	[1]		c(m)
												M1			AF437735	[1]		c(m)
												M2			AF437735	[1]		c(m)
	IGHW	(3)	IGHW*01	(F)								CH1			AF437727	[1]	(1)	c(s)		AF437726	[1]		c
												CH2			AF437727	[1]		c(s)		AF437727	[1]		c
												CH3			AF437727	[1]		c(s)
												CH4			AF437727	[1]		c(s)
												CH5			AF437727	[1]		c(s)
												CH6			AF437727	[1]		c(s)
												CH7 (including CHS)			AF437727	[1]		c(s)

c: cDNA sequence.
(s): transcript of a secreted chain.
(m): transcript of a membrane chain.

IMGT notes:

(1) The 1st-CYS is not conserved in CH1.
(2) Partial C-REGION: partial CH1 in 5'.
(3) The IGHW gene has two transcribed forms: a short form which consists of only the CH1 and the CH2 exons, and a long form which consists of the CH1 to CH7 exons. Nucleotide sequence analysis suggests that these short and long forms derive from an alternative splicing [1].

IMGT references:

[1] Ota T. et al., Proc. Natl. Acad. Sci. U.S.A., 100, 2501-2506 (2003). PMID:12606718

See also (IMGT Scientific chart):

Created:: 24/07/2003
Last updated:: 22/09/2023
Authors:: Nathalie Bosc

IMGT Repertoire (IG and TR)

Gene table: marbled lungfish (Protopterus aethiopicus) IGHC