Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name IMGT allele name Fct Haplotypes T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHA IGHA*01 F + IgA-A.I CH1 AY039245 [2] RGR.1 AY294619 [5] (3)
H+CH2 (1) AY039245 [2] RGR.1 AY294619 [5] (3)
CH3 (including CHS) AY039245 [2]
IGHA*02 F IgA-A.II CH1 AY039246 [2]
H+CH2 (1) AY039246 [2]
CH3 (including CHS) AY039246 [2]
IGHA*03 F IgA-B.II CH1 AY039247 [2]
H+CH2 (1) AY039247 [2]
CH3 (including CHS) AY039247 [2]
IGHA*04 F + IgA-B.I CH1 AY039248 [2] RWy2.1 AY294622 [5] (3)
H+CH2 (1) AY039248 [2] RWy2.1 AY294622 [5] (3)
CH3 (including CHS) AY039248 [2]
IGHA*05 F IgA-C.I CH1 AY039249 [2]
H+CH2 (1) AY039249 [2]
CH3 (including CHS) AY039249 [2]
IGHA*06 F IgA-D.I CH1 AY039250 [2]
H+CH2 (1) AY039250 [2]
CH3 (including CHS) AY039250 [2]
IGHA*07 F IgA-D.II CH1 AY039251 [2]
H+CH2 (1) AY039251 [2] UTS372 AB013760 [3] (2)
CH3 (including CHS) AY039251 [2]
IGHA*08 F IgA-C.II CH1 AY039252 [2]
IgA-D.I H+CH2 (1) AY039252 [2]
CH3 (including CHS) AY039252 [2]
IGHA*09 F UTS378 C alpha CH1 AB013768 [3] (3)
H+CH2 (1) AB013768 [3] (3)
UTS520 C alpha CH1 AB013769 [3] (3)
IGHA*10 F UTS520 C alpha H+CH2 (1) AB013769 [3] (3)
IGHA*11 F UTS493 C alpha CH1 AB013767 [3] (3)
H+CH2 (1) AB013767 [3] (3)
IGHA*12 F UTS380 C alpha H+CH2 (1) AB013757 [3] (2)
IGHA*13 F UTS382 C alpha H+CH2 (1) AB013761 [3] (2)
IGHA*14 (F) + RUa8 CH1 AY294614 [5] c(s)
H+CH2 (1) AY294614 [5] c(s)
CH3 (including CHS) AY294614 [5] c(s)
IGHA*15 (F) + RGz7 RGz7.1 CH1 AY294616 [5] (3)
H+CH2 (1) AY294616 [5] (3)
IGHA*16 (F) + RGz7 RGz7.2 CH1 AY294617 [5] (3)
H+CH2 (1) AY294617 [5] (3)
IGHA*17 (F) + RGR RGR.2 CH1 AY294618 [5] (3)
H+CH2 (1) AY294618 [5] (3)
IGHA*18 (F) + RLi1 RLi1.1 CH1 AY294620 [5] (3)
H+CH2 (1) AY294620 [5] (3)
IGHA*19 (F) + RLi1 RLi1.2 CH1 AY294621 [5] (3)
H+CH2 (1) AY294621 [5] (3)
IGHA*20 (F) + RWy2 RWy2.2 CH1 AY294623 [5] (3)
H+CH2 (1) AY294623 [5] (3)
IGHA*21 (F) + RGz7 CH1 AY294615 c(s)
H+CH2 (1) AY294615 c(s)
CH3 (including CHS) AY294615 c(s)
IGHA*22 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1956843..1957142
H+CH2 IMGT000064 MAP 1957357..1957689
CH3 (including CHS) IMGT000064 MAP 1957901..1958232
M IMGT000064 MAP 1960848..1961059
IGHD IGHD*01 (F) + CH1 DQ297181 [7] (5)
H1 DQ297181 [7] (5)
H2 DQ297181 [7] (5)
CH2 DQ297181 [7] (5)
CH3 DQ297181 [7] (5)
IGHD*02 (F) + CH1 DQ297180 [7] (5)
H1 DQ297180 [7] (5)
H2 DQ297180 [7] (5)
CH2 DQ297180 [7] (5)
CH3 DQ297180 [7] (5)
IGHD*03 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1722155..1722463
H1 IMGT000064 MAP 1722947..1723048
H2 IMGT000064 MAP 1726496..1726557
CH2 IMGT000064 MAP 1727290..1727613
CH3 IMGT000064 MAP 1727917..1728240
CHS IMGT000064 MAP 1730163..1730188 17573 CM000293.1 NW_001121238 [6] (6) complement(184669..184694)
M1 IMGT000064 MAP 1730991..1731148 17573 CM000293.1 NW_001121238 [6] (6) complement(183710..183867)
M2 IMGT000064 MAP 1731432..1731437 17573 CM000293.1 NW_001121238 [6] (6) complement(183418..183426)
IGHE IGHE*01 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1943782..1944090
CH2 IMGT000064 MAP 1944288..1944608
CH3 IMGT000064 MAP 1944694..1945020
CH4 (including CHS) IMGT000064 MAP 1945107..1945429
M1 IMGT000064 MAP 1947523..1947644
M2 IMGT000064 MAP 1947729..1947812
IGHG1 IGHG1*01 F 17573 CM000293.1 CH1 NW_001121238 [6] complement(117212..117505)
H NW_001121238 [6] complement(116767..116820)
CH2 NW_001121238 [6] complement(116319..116648)
CH3 (including CHS) NW_001121238 [6] complement(115908..116221)
M1 NW_001121238 [6] complement(114454..114584)
M2 NW_001121238 [6] complement(112173..112256)
IGHG1*02 F Indian isolate RWy2 CH1 AY292507 [5] Chinese isolate RJz7 AY292502 [5] (5)
Chinese isolate RGz7 AY292503 [5] (5)
Chinese isolate RUa8 AY292504 [5] (5)
Indian isolate RGr AY292505 [5] (5)
Indian isolate RLi1 AY292506 [5] (5)
H AY292507 [5] Chinese isolate RJz7 AY292502 [5] (5)
Chinese isolate RGz7 AY292503 [5] (5)
Chinese isolate RUa8 AY292504 [5] (5)
Indian isolate RGr AY292505 [5] (5)
Indian isolate RLi1 AY292506 [5] (5)
CH2 AY292507 [5] Chinese isolate RJz7 AY292502 [5] (5)
Chinese isolate RGz7 AY292503 [5] (5)
Chinese isolate RUa8 AY292504 [5] (5)
Indian isolate RGr AY292505 [5] (5)
Indian isolate RLi1 AY292506 [5] (5)
CH3 (including CHS) AY292507 [5] Chinese isolate RJz7 AY292502 [5] (5)
Chinese isolate RGz7 AY292503 [5] (5)
Chinese isolate RUa8 AY292504 [5] (5)
Indian isolate RGr AY292505 [5] (5)
Indian isolate RLi1 AY292506 [5] (5)
IGHG1*03 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1796884..1797177
H IMGT000064 MAP 1797569..1797622
CH2 IMGT000064 MAP 1797741..1798070
CH3 (including CHS) IMGT000064 MAP 1798168..1798481
M1 IMGT000064 MAP 1799786..1799916
M2 IMGT000064 MAP 1802382..1802465
IGHG2 IGHG2*01 F Indian isolate RWy2 CH1 AY292519 [5] (5)
H AY292519 [5] (5)
CH2 AY292519 [5] (5)
CH3 (including CHS) AY292519 [5] (5)
IGHG2*02 F Chinese isolate RJz7 CH1 AY292514 [5] (5) Chinese isolate RGz7 AY292515 [5] (5)
Chinese isolate RUa8 AY292516 [5] (5)
H AY292514 [5] (5) Chinese isolate RGz7 AY292515 [5] (5)
Chinese isolate RUa8 AY292516 [5] (5)
CH2 AY292514 [5] (5) Chinese isolate RGz7 AY292515 [5] (5)
Chinese isolate RUa8 AY292516 [5] (5)
CH3 (including CHS) AY292514 [5] (5) Chinese isolate RGz7 AY292515 [5] (5)
Chinese isolate RUa8 AY292516 [5] (5)
IGHG2*03 F Indian isolate RGr CH1 AY292517 [5] (5)
H AY292517 [5] (5)
CH2 AY292517 [5] (5)
CH3 (including CHS) AY292517 [5] (5)
IGHG2*04 F Indian isolate RLi1 CH1 AY292518 [5] (5)
H AY292518 [5] (5)
CH2 AY292518 [5] (5)
CH3 (including CHS) AY292518 [5] (5)
IGHG2*05 (F) + 1D2/1D5 CH1 AF045539 [1] c(s)
H AF045539 [1] c(s)
CH2 AF045539 [1] c(s)
CH3 (including CHS) AF045539 [1] c(s)
IGHG2*06 F PMac CH1 AF300440 [4] (3)
H AF300440 [4] (3)
CH2 AF300440 [4] (3)
IGHG2*07 F 17573 CM000293.1 CH3 (including CHS) NW_001121238 [6] complement(43796..44109)
M1 NW_001121238 [6] complement(42358..42488)
M2 NW_001121238 [6] complement(40410..40493)
IGHG2*08 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1862106..1862399
H IMGT000064 MAP 1862788..1862823
CH2 IMGT000064 MAP 1862942..1863268
CH3 (including CHS) IMGT000064 MAP 1863366..1863679
M1 IMGT000064 MAP 1864986..1865116
M2 IMGT000064 MAP 1867127..1867210
IGHG3 IGHG3*01 F Indian isolate RLi1 CH1 AY292512 [5] (5) Indian isolate RWy2 AY292513 [5] (5)
H AY292512 [5] (5) Indian isolate RWy2 AY292513 [5] (5)
CH2 AY292512 [5] (5) Indian isolate RWy2 AY292513 [5] (5)
CH3 (including CHS) AY292512 [5] (5) Indian isolate RWy2 AY292513 [5] (5)
IGHG3*02 F Indian isolate RGr CH1 AY292511 [5] (5)
H AY292511 [5] (5)
CH2 AY292511 [5] (5)
CH3 (including CHS) AY292511 [5] (5)
IGHG3*03 F Chinese isolate RJz7 CH1 AY292508 [5] (5) Indian isolate RGr AY292509 [5] (5)
H AY292508 [5] (5) Indian isolate RGr AY292509 [5] (5)
CH2 AY292508 [5] (5) Indian isolate RGr AY292509 [5] (5)
CH3 (including CHS) AY292508 [5] (5) Indian isolate RGr AY292509 [5] (5)
IGHG3*04 F Indian isolate RUa8 CH1 AY292510 [5] (5)
H AY292510 [5] (5)
CH2 AY292510 [5] (5)
CH3 (including CHS) AY292510 [5] (5)
IGHG3*05 (P) (9) + CH1 AF045538 [1] (4) c(m)
H AF045538 [1] (4) c(m)
CH2 AF045538 [1] (4) c(m)
CH3 AF045538 [1] (4) c(m)
M1 AF045538 [1] (4) c(m)
IGHG3*06 F PMac CH1 AF300438 [4] (3)
H AF300438 [4] (3)
CH2 AF300438 [4] (3)
CH3 (including CHS) AF300438 [4] (3)
IGHG3*07 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1888750..1889043 17573 CM000293.1 NW_001121238 [6] (7) complement(20216..20509)
H IMGT000064 MAP 1889433..1889483
CH2 IMGT000064 MAP 1889602..1889931
CH3 (including CHS) IMGT000064 MAP 1890029..1890342
M1 IMGT000064 MAP 1891649..1891779
M2 IMGT000064 MAP 1894491..1894574 17573 CM000293.1 NW_001121238 [6] (7) complement(14327..14410)
IGHG4 IGHG4*01 F Chinese isolate RGr CH1 AY292520 [5] (5) Indian isolate RWy2 AY292521 [5] (5)
H AY292520 [5] (5) Indian isolate RWy2 AY292521 [5] (5)
CH2 AY292520 [5] (5) Indian isolate RWy2 AY292521 [5] (5)
CH3 (including CHS) AY292520 [5] (5) Indian isolate RWy2 AY292521 [5] (5)
IGHG4*02 F Indian isolate RLi1 CH1 AY292522 [5] (5)
H AY292522 [5] (5)
CH2 AY292522 [5] (5)
CH3 (including CHS) AY292522 [5] (5)
IGHG4*03 F Chinese isolate RJz7 CH1 AY292523 [5] (5) Chinese isolate RGz7 AY292524 [5] (5)
H AY292523 [5] (5) Chinese isolate RGz7 AY292524 [5] (5)
CH2 AY292523 [5] (5) Chinese isolate RGz7 AY292524 [5] (5)
CH3 (including CHS) AY292523 [5] (5) Chinese isolate RGz7 AY292524 [5] (5)
IGHG4*04 F Chinese isolate RGz7 CH1 AY292525 [5] (5)
H AY292525 [5] (5)
CH2 AY292525 [5] (5)
CH3 (including CHS) AY292525 [5] (5)
IGHG4*05 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1913065..1913358
H IMGT000064 MAP 1913752..1913781
CH2 IMGT000064 MAP 1913900..1914229
CH3 (including CHS) IMGT000064 MAP 1914327..1914640
M1 IMGT000064 MAP 1915949..1916079
M2 IMGT000064 MAP 1919557..1919640
IGHM IGHM*01 (F) + CH1 AF046784 [1] (4) c(m)
CH2 AF046784 [1] (4) c(m)
CH3 AF046784 [1] (4) c(m)
CH4 (including CHS) AF046784 [1] (4) c(m)
M1 AF046784 [1] (4) c(m)
M2 AF046784 [1] (4) c(m)
IGHM*02 P (8) 17573 CM000293.1 CH1 NW_001121238 [6] complement(203083..203376)
CH2 NW_001121238 [6] complement(202656..202991)
CH3 NW_001121238 [6] complement(202116..202433)
CH4 (including CHS) NW_001121238 [6] complement(201604..201935)
IGHM*03 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1712265..1712579
CH2 IMGT000064 MAP 1712670..1713005
CH3 IMGT000064 MAP 1713228..1713545
CH4 (including CHS) IMGT000064 MAP 1713726..1714057
M1 IMGT000064 MAP 1716180..1716295
M2 IMGT000064 MAP 1716485..1716490

MAP: Mapped reference sequences.
c: cDNA sequence.
(s): trancript of a secreted chain.
(m): trancript of a membrane chain.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and CH2 are joined in a single exon.
  2. (2) Partial C-GENE: no CH1 and CH2 is partial in 3'
  3. (3) Partial C-GENE: CH1 is partial in 5' and CH2 is partial in 3'
  4. (4) Partial C-GENE: M1 is partial in 3'
  5. (5) Partial C-GENE: CH3 is partial in 3'
  6. (6) Partial C-GENE: no CH1, H1, H2, CH2 and CH3
  7. (7) Partial C-GENE: no H, CH2, CH3 and M1
  8. (8) pseudogene: frameshifts in CH1
  9. (9) pseudogene: frameshift in M1
IMGT references:
  1. [1] Calvas P. et al., Scand. J. Immunol., 49, 595-610 (1999). PMID: 10354371
  2. [2] Scinicariello F. and Attanasio R., Immunology, 103, 441-448 (2001). PMID: 11529934
  3. [3] Sumiyama K. et al., Mol. Biol. Evol., 19, 1093-1099 (2002). PMID: 12082128
  4. [4] Fortenfant F.et al., Unpublished (2002).
  5. [5] Scinicariello,F. et al., Immunology 111 (1), 66-74 (2004). PMID: 14678200
  6. [6] Gibbs R.A. et al., Science. 316(5822):222-234 (2007).
  7. [7] Rogers K.A. et al., Immunology 118(1):88-100 (2006). PMID: 16630026
Created:
15/02/2021
Last updated:
23/09/2021
Authors:
Alexandre Albani, Saida Saljoqi, Nathalie Bosc, Gérard Lefranc, Sofia Kossida, Marie-Paule Lefranc