IMGT Repertoire (IG and TR)


Gene table: Alpaca (Vicugna pacos) IGHV

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Based on the presence of an arginine (Arg, R) in the V-REGION at position 50 (R50), instead of a leucine (Leu, L) (L50) or proline (Pro, P) (P50) (IMGT unique numbering), the following IGHV genes of Vicugna pacos (alpaca), IGHV3-3 and IGHV3S53 to IGHV3S68, most probably will be found expressed in VH domains of only-heavy-chain antibodies, or VHH.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)		 Secondary accession numbers Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
IGHV1 IGHV1-1 IGHV1-1*01 F 4 vh1-1 AM773729 [1] complement (32604..33080)
IGHV1S2 IGHV1S2*01 F 4 VH1-S2 AM939697 [1]
IGHV1S3 IGHV1S3*01 F 4 VH1-S3 AM939698 [1]
IGHV1S4 IGHV1S4*01 F 4 VH1-S4 AM939699 [1]
IGHV1S5 IGHV1S5*01 P (1) 4 VH1-S5 AM939700 [1]
IGHV1S6 IGHV1S6*01 F 4 VH1-S6 AM939701 [1]
IGHV3 IGHV3-1 IGHV3-1*01 F 4 vh3-1 AM773729 [1] 12630..13125
IGHV3-2 IGHV3-2*01 F 4 vh3-2 AM773729 [1] complement (27825..28320)
IGHV3-3 IGHV3-3*01 F 4 vhh3-1 AM773729 [1] 526..1019
IGHV3S1 IGHV3S1*01 F 4 vh3-S1 AM773548 [1] 6691..7186
IGHV3S2 IGHV3S2*01 F 4 VH3-S2 AM939716 [1]
IGHV3S3 IGHV3S3*01 ORF (4) 4 VH3-S3 AM939728 [1]
IGHV3S4 IGHV3S4*01 F 4 VH3-S4 AM939738 [1]
IGHV3S5 IGHV3S5*01 F 4 VH3-S5 AM939748 [1]
IGHV3S6 IGHV3S6*01 F 4 VH3-S6 AM939749 [1]
IGHV3S7 IGHV3S7*01 F 4 VH3-S7 AM939750 [1]
IGHV3S8 IGHV3S8*01 F 4 VH3-S8 AM939751 [1]
IGHV3S9 IGHV3S9*01 F 4 VH3-S9 AM939767 [1]
IGHV3S10 IGHV3S10*01 F 4 VH3-S10 AM939768 [1]
IGHV3S11 IGHV3S11*01 F 4 VH3-S11 AM939707 [1]
IGHV3S12 IGHV3S12*01 F 4 VH3-S12 AM939708 [1]
IGHV3S13 IGHV3S13*01 F 4 VH3-S13 AM939709 [1]
IGHV3S14 IGHV3S14*01 F 4 VH3-S14 AM939710 [1]
IGHV3S15 IGHV3S15*01 F 4 VH3-S15 AM939711 [1]
IGHV3S16 IGHV3S16*01 F 4 VH3-S16 AM939712 [1]
IGHV3S17 IGHV3S17*01 F 4 VH3-S17 AM939713 [1]
IGHV3S18 IGHV3S18*01 F 4 VH3-S18 AM939714 [1]
IGHV3S19 IGHV3S19*01 P (3) 4 VH3-S19 AM939715 [1]
IGHV3S20 IGHV3S20*01 F 4 VH3-S20 AM939718 [1]
IGHV3S21 IGHV3S21*01 P (1) 4 VH3-S21 AM939719 [1]
IGHV3S22 IGHV3S22*01 P (1) 4 VH3-S22 AM939720 [1]
IGHV3S23 IGHV3S23*01 P (1) 4 VH3-S23 AM939721 [1]
IGHV3S24 IGHV3S24*01 P (1) 4 VH3-S24 AM939722 [1]
IGHV3S25 IGHV3S25*01 F 4 VH3-S25 AM939723 [1]
IGHV3S26 IGHV3S26*01 F 4 VH3-S26 AM939724 [1]
IGHV3S27 IGHV3S27*01 F 4 VH3-S27 AM939725 [1]
IGHV3S28 IGHV3S28*01 F 4 VH3-S28 AM939726 [1]
IGHV3S29 IGHV3S29*01 F 4 VH3-S29 AM939727 [1]
IGHV3S30 IGHV3S30*01 F 4 VH3-S30 AM939729 [1]
IGHV3S31 IGHV3S31*01 F 4 VH3-S31 AM939730 [1]
IGHV3S32 IGHV3S32*01 F 4 VH3-S32 AM939731 [1]
IGHV3S33 IGHV3S33*01 F 4 VH3-S33 AM939732 [1]
IGHV3S34 IGHV3S34*01 F 4 VH3-S34 AM939733 [1]
IGHV3S35 IGHV3S35*01 F 4 VH3-S35 AM939734 [1]
IGHV3S36 IGHV3S36*01 F 4 VH3-S36 AM939735 [1]
IGHV3S37 IGHV3S37*01 F 4 VH3-S37 AM939736 [1]
IGHV3S38 IGHV3S38*01 F 4 VH3-S38 AM939717 [1]
IGHV3S39 IGHV3S39*01 F 4 VH3-S39 AM939737 [1]
IGHV3S40 IGHV3S40*01 F 4 VH3-S40 AM939739 [1]
IGHV3S41 IGHV3S41*01 F 4 VH3-S41 AM939740 [1]
IGHV3S42 IGHV3S42*01 F 4 VH3-S42 AM939741 [1]
IGHV3S43 IGHV3S43*01 F 4 VH3-S43 AM939742 [1]
IGHV3S44 IGHV3S44*01 F 4 VH3-S44 AM939743 [1]
IGHV3S45 IGHV3S45*01 F 4 VH3-S45 AM939744 [1]
IGHV3S46 IGHV3S46*01 F 4 VH3-S46 AM939745 [1]
IGHV3S47 IGHV3S47*01 P (5) 4 VH3-S47 AM939746 [1]
IGHV3S48 IGHV3S48*01 P (6) 4 VH3-S48 AM939747 [1]
IGHV3S49 IGHV3S49*01 P (7) 4 VH3-S49 AM939774 [1]
IGHV3S50 IGHV3S50*01 P (7) 4 VH3-S50 AM939775 [1]
IGHV3S51 IGHV3S51*01 P (8) 4 VH3-S51 AM939776 [1]
IGHV3S52 IGHV3S52*01 P (8) 4 VH3-S52 AM939777 [1]
IGHV3S53 IGHV3S53*01 F 4 vhh3-S1 AM773548 [1] 33684..34176
IGHV3S54 IGHV3S54*01 F 4 VHH3-S2 AM939756 [1]
IGHV3S55 IGHV3S55*01 F 4 VHH3-S9 AM939763 [1]
IGHV3S56 IGHV3S56*01 F 4 VHH3-S10 AM939764 [1]
IGHV3S57 IGHV3S57*01 F 4 VHH3-S11 AM939765 [1]
IGHV3S58 IGHV3S58*01 F 4 VHH3-S12 AM939752 [1]
IGHV3S59 IGHV3S59*01 F 4 VHH3-S13 AM939753 [1]
IGHV3S60 IGHV3S60*01 F 4 VHH3-S14 AM939754 [1]
IGHV3S61 IGHV3S61*01 F 4 VHH3-S3 AM939757 [1]
IGHV3S62 IGHV3S62*01 F 4 VHH3-S4 AM939758 [1]
IGHV3S63 IGHV3S63*01 F 4 VHH3-S5 AM939759 [1]
IGHV3S64 IGHV3S64*01 F 4 VHH3-S6 AM939760 [1]
IGHV3S65 IGHV3S65*01 F 4 VHH3-S7 AM939761 [1]
IGHV3S66 IGHV3S66*01 F 4 VHH3-S8 AM939762 [1]
IGHV3S67 IGHV3S67*01 F 4 VHH3-S15 AM939766 [1]
IGHV3S68 IGHV3S68*01 F 4 VHH3-S16 AM939755 [1]
IGHV4 (9) IGHV4S1 IGHV4S1*01 F 4 vh2-S1 AM773548 [1] 23764..24244
IGHV4S2 IGHV4S2*01 F 4 VH2-S2 AM939769 [1]
IGHV4S3 IGHV4S3*01 F 4 VH2-S3 AM939770 [1]
IGHV4S4 IGHV4S4*01 F 4 VH2-S4 AM939771 [1]
IGHV4S5 IGHV4S5*01 F 4 VH2-S5 AM939772 [1]
IGHV4S6 IGHV4S6*01 F 4 VH2-S6 AM939773 [1]
IGHV4S7 IGHV4S7*01 F 4 VH2-S7 AM939704 [1]
IGHV4S8 IGHV4S8*01 F 4 VH2-S8 AM939705 [1]
IGHV4S9 IGHV4S9*01 P (2) 4 VH2-S9 AM939706 [1]
IGHV4S10 IGHV4S10*01 F 4 VH2-S10 VH2-S10 AM939702 [1]
IGHV4S11 IGHV4S11*01 P (1) 4 VH2-S11 AM939703 [1]
IMGT notes:
  1. (1) In frame STOP-CODON in FR2-IMGT
  2. (2) In frame STOP-CODON in FR1-IMGT and in FR2-IMGT
  3. (3) in frame STOP-CODON in FR3-IMGT
  4. (4) CONSERVED-TRP is repalced by Arg
  5. (5) in frame STOP-CODON in FR2-IMGT, 1st-CYS is repalced by Arg
  6. (6) in frame STOP-CODON in in FR2-IMGT and in FR3-IMGT
  7. (7) Frameshift in CDR1-IMGT and in FR2-IMGT, deletion one nucleotide in CDR1-IMGT and one nucleotide in FR2-IMGT
  8. (8) Frameshift in FR1-IMGT, insertion one nucleotide in FR1-IMGT
  9. (9) Previously annotated as IGHV2 subgroup
IMGT references:
  1. [1] Achour I. et al., J. Immunol. 181:2001-2009 (2008). PMID:18641337
Created:
28/06/2016
Last updated:
22/09/2023
Authors:
Joumana Michaloud, Géraldine Folch