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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Rearranged (R) and transcribed (T) information are from Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRGV.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)		 Secondary accession numbers Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
TRGV1 TRGV1 TRGV1*01 ORF (11) 7p14 - - - V1 MAP M12949 [1] (1) 1..495 V1S1P AF159056 [8] (12) 5892..6386
CM000669.2 IMGT000011 (11) 20001..20495
TRGV2 TRGV2*01 F 7p14 + + + V2 MAP M13429 [1] (13) 1..504 V1S2 AF159056 [8] (12) 10623..11126
TRGV2*02 (F) 7p14 + + + Vgamma1.9 M27337 [10] #c
TRGV2*03 F 7p14 + + + CM000669.2 IMGT000011 24728..25231
TRGV3 TRGV3*01 F 7p14 + + + V3 MAP M13430 [1] (15) 1..507 V1S3 AF159056 [8] (12) 14972..15478
CM000669.2 IMGT000011 29077..29583
TRGV3*02 F 7p14 + + + Vgamma1.1 MAP X04038 [2] 172..676
TRGV3P TRGV3P*01 (14) 7p14
TRGV4 TRGV4*01 F 7p14 + + + V4 MAP X15272 [6] 237..744 V1S4 AF159056 [8] (12) 19769..20276
TRGV4*02 F 7p14 + + + V4 MAP X13354 [4] 1..508 M36285 [4] CM000669.2 IMGT000011 33873..34380
TRGV5 TRGV5*01 F 7p14 + + + V5 MAP X13355 [4] 1..509 M36286 [4] V1S5 AF159056 [8] (12) 24128..24636
V1S5, CM000669.2 IMGT000011 38232..38740
TRGV5P TRGV5P*01 P (2) 7p14 - - - V5P MAP M13431 [1] 1..507
TRGV5P*02 P (2) 7p14 V1S5P AF159056 [8] (12) 28453..28961 CM000669.2 IMGT000011 (2) 42557..43065
TRGV6 TRGV6*01 P (3) 7p14 - - - V6 MAP M13432 [1] 1..510 CM000669.2 IMGT000011 46885..47395
TRGV6*02 P (3) 7p14 V1S6P AF159056 [8] (12) 32787..33297
TRGV7 TRGV7*01 P (4) 7p14 + + - V7 MAP M13433 [1] 1..409 V1S7P AF159056 [8] (12) 32787..33297
CM000669.2 IMGT000011 52542..53054
TRGV8 TRGV8*01 F 7p14 + + + V8 MAP M13434 [1] (16) 1..518 V1S8 AF159056 [8] (12) 43134..43651
CM000669.2 IMGT000011 57235..57752
TRGV2 TRGV9 TRGV9*01 F 7p14 + + + V9*A1 MAP X07205 [3] 7..522 V2 AF159056 [8] 56447..56962
CM000669.2 IMGT000011 70564..71078
TRGV9*02 F 7p14 + + + V9*A2 MAP X15274 [6] 657..1171
TRGV3 TRGV10 TRGV10*01 ORF (5,6) 7p14 + + - V10*A1 MAP X07206 [3] 1..513
TRGV10*02 ORF (5,6) 7p14 + + - V10*A2 MAP X74798 [7] 1..>493 V3P AF159056 [8] 73632..74141
CM000669.2 IMGT000011 87776..88284
TRGV4 TRGV11 TRGV11*01 ORF (7,8) 7p14 + + - V11 MAP Y11227 [5] 1..502 CM000669.2 IMGT000011 95978..96479
TRGV11*02 ORF (7,8) 7p14 V4P AF159056 [8] 81836..82337
TRGVA TRGVA TRGVA*01 P (9) 7p14 - - - VA MAP X07208 [3] 1..457 V5P AF159056 [8] (12) 51077..51533
CM000669.2 IMGT000011 65235..65649
TRGVB TRGVB TRGVB*01 P (10) 7p14 - - - VB MAP X07209 [3] 1..510 V6P AF159056 [8] 77681..78190
TRGVB*02 P (10) 7p14 CM000669.2 IMGT000011 [1,3] 91823..92332

#c: rearranged cDNA.
#g: rearranged genomic DNA.

IMGT notes:
  1. (1) X15269 [6] is the 5'UTR of TRGV1*01 (M12949). The two sequences overlap by 4 nucleotides including the INIT-CODON ATG.
  2. (2) STOP-CODON in the L-PART1.
  3. (3) Frameshift in V-REGION: deletion of 1 nt in FR3-IMGT.
  4. (4) Frameshift in V-REGION: deletion of 1 nt in FR3-IMGT at position 346-347at position 346-347.
  5. (5) Noncanonical DONOR-SPLICE: nct instead of ngt.
  6. (6) Absence of splicing of the V10 leader intron ([7,9]).
  7. (7) Absence of splicing of the V11 leader intron ([7,9]).
  8. (8) No 1st-CYS: Trp instead of Cys.
  9. (9) STOP-CODON in frame in V-REGION.
  10. (10) STOP-CODON in L-PART1, frameshifts in V-REGION.
  11. (11) Noncanonical V-NONAMER: gtggttgct instead of ctgaaaatc.
  12. (12) The sequence AF057177 (53151 bp) is included in AF159056 (nt 1-53151 of 140691 bp) and is not reported in this table to avoid redundancy. Both sequences start 5.8 kb upstream of TRGV1. AF057177 ends 1.6 kb downstream of TRGVA, whereas AF159056 encompasses the entire locus and ends 6.8 kb downstream of TRGC2 EX3.
  13. (13) X15270 [6] is the 5'UTR of TRGV2*01 (M13429). The two sequences overlap by 4 nucleotides including the INIT-CODON ATG.
  14. (14) Polymorphic gene by insertion identified by Southern hybridization [11].
  15. (15) X15271 [6] is the 5'UTR of TRGV3*01 (M13430). The two sequences overlap by 4 nucleotides including the INIT-CODON ATG.
  16. (16) X15273 [6] is the 5'UTR of TRGV8*01 (M13434). The two sequences overlap by 4 nucleotides including the INIT-CODON ATG.
IMGT references:
  1. [1] Lefranc M.-P. et al., Cell, 45, 237-246 (1986). PMID:2938743
  2. [2] Quertermous T. et al., Nature, 322, 184-187 (1986). PMID:3453106
  3. [3] Huck S. et al., EMBO J., 7, 719-726 (1988). PMID:2969332
  4. [4] Font M.P. et al., J. Exp. Med., 168, 1383-1394 (1988). PMID:2902186
  5. [5] Chen Z. et al., Blood, 72, 776-783 (1988). PMID:2969758
  6. [6] Dariavach P. and Lefranc, M.-P., FEBS Lett., 256, 185-191 (1989). PMID:2806544
  7. [7] Zhang X.M. et al., Eur. J. Immunol., 24, 571-578 (1994). PMID:8125127
  8. [8] Zhang M., Wang K., Zhou Q., McKinnell L., Lefranc M-P., Hood L., Koop B. (1999).
  9. [9] Zhang X.M. et al., Immunogenetics, 43, 196-203 (1996). PMID:8575818
  10. [10] Yoshikai Y. et al., Eur.J.Immunol., 17, 119-126 (1987). PMID:2949984
  11. [11] Ghanem et al., Hum. Genet., 86, 450-456 (1991). PMID:1673112
Created:
07/10/1996
Last updated:
22/09/2023
Authors:
Anne Bouisson, Géraldine Folch