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House mouse (Mus musculus) IGH locus on chromosome 12 (12F2) strain C57BL/6

The orientation of the house mouse (Mus musculus) IGH locus on the chromosome 12 (12F2) strain C57BL/6 is reverse (REV).

Locus representation mouse IGH

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3' borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and are not included in the numbers displayed at the right ends of these two lines.

SWITCH sequences are represented by a filled circle upstream of the IGHC genes.

The Mouse (Mus musculus) IGHV genes belong to 16 subgroups (Gene tables: Mouse IGHV) which are part of three clans (Figure IGHV clans). Clans comprise, respectively:

  • clan I: IGHV1, IGHV9; IGHV14 and IGHV15 subgroup genes and one pseudogene IGHV(I)
  • clan II: IGHV2, IGHV3, IGHV8 and IGHV12 subgroup genes and pseudogenes IGHV(II)
  • clan III: IGHV4, IGHV5, IGHV6, IGHV7, IGHV10, IGHV11, IGHV13 and IGHV16 subgroup genes and pseudogenes IGHV(III).

Locus representation with only the functional genes: house mouse (Mus musculus) IGH

Locus representation mouse IGH

* When needed, indicate the presence of allele(s) with another functionality: see above house mouse (Mus musculus) IGH locus

IMGT references:
 IGHV genes
  1. [1] Crews, S. et al., Cell, 25, 59-66 (1981).
  2. [2] Brodeur, P.H. and Riblet, R., Eur. J. Immunol. 14, 922-930 (1984).
  3. [3] Winter, E. et al., EMBO J., 4, 2861-2867 (1985).
  4. [4] Brodeur, P.H. et al., J. Exp. Med., 168, 2261-2278 (1988).
  5. [5] Kofler, R. et al., J. Immunol., 140, 4031-4034 (1988).
  6. [6] Pennell, C.A. et al., Eur. J. Immunol., 19, 2115-2121 (1989).
  7. [7] Tutter, A. et al., J. Immunol., 147, 3215-3223 (1991).
  8. [8] Kofler, R. et al., Immunol. Rev., 128, 5-21 (1992).
  9. [9] Sims, M.J. et al., J. Immunol., 149, 1642-1648 (1992).
  10. [10] Sheehan, K.M. et al., J. Immunol., 151, 5364-5375 (1993).
  11. [11] Mainville, C.A. et al., J. Immunol., 156, 1058-1046 (1996).
  12. [12] Almagro, J.C. et al., Mol. Immunol., 34, 119-1214 (1997).
IGHD genes
  1. [13] Kurosawa, Y. and Tonegawa, S., J. Exp. Med., 155, 201-218 (1982).
  2. [14] Woods, C. and Tonegawa, S., Proc. Natl. Acad. Sci. USA 80, 3030-3034 (1983).
  3. [15] Feeney, A.J and Ribbet, R., Immunogenetics, 37, 217-221 (1993).
IGHJ genes
  1. [16] Early, P. et al., Cell, 19, 981-992 (1980).
  2. [17] Newell, N. et al., Science, 209, 1128-1132 (1980).
  3. [18] Sakano, H. et al., Nature, 286, 676-683 (1980).
IGHC genes
  1. [19] Edelman, G.M. et al., Proc. Natl. Acad. Sci. USA, 63, 78-85 (1969).
  2. [20] Honjo, T. and Kataoka,T., Proc. Natl Acad. Sci. USA, 75, 2140-2144 (1978).
  3. [21] Honjo, T. et al., Immunological Rev., 59, 33-67 (1981).
  4. [22] Yamawaki-Kataoka, Y. et al., Proc. Natl. Acad. Sci. USA, 79, 2623-2627 (1982).
  5. [23] Shimiza, A. et al., Cell, 28, 499-506 (1982).
IGH locus from the C57BL/6 genome sequencing
  1. [24] Riblet, R. In: Molecular Biology of B cells. Honjo, T., Alt, F.W. and Neuberger, M. eds, Elsevier Academic Press, London, pp 19-26 (2004).
  2. [25] Folch, G., Giudicelli, V., Jean, C., Ginestoux, C., Lefranc G. and Lefranc, M.-P. IMGT overview: the mouse immunoglobulin heavy IGH genes.19th International Mouse Genome Conference (IMGC), November 5-8, 2005, Strasbourg, France (2005)..
More information:
Created:
05/11/2005
Last updated:
14/05/2018
Authors:
Géraldine Folch