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There are one or two functional HLA-DRB genes per haplotype (Locus representation: HLA-DR haplotype).

The HLA-DRB3/4/5 gene, if present, is located in telomeric position compared to HLA-DRB1 in the MHC locus at 6p21.3 (IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView).

When, for simplification, alleles are indicated with only two numbers in this table, see Correspondence between serological families and alleles: Human MHC (HLA) for a complete list of alleles (this list identifies alleles with known serology, null alleles or alleles with non defined serology).

HLA-DRB3/4/5 HLA-DRB1
DR serological families
encoded by the HLA-DRB3/4/5 alleles
HLA-DRB3/4/5 alleles DR serological families
encoded by the HLA-DRB1 alleles
HLA-DRB1 alleles
Unsplit Split
none - (1) DR1 DR1 HLA-DRB1*01
DR10 HLA-DRB1*10
DR103 HLA-DRB1*0103
DR51 HLA-DRB5*01,*02 DR2 DR2 HLA-DRB1*1508, *1603
DR15 HLA-DRB1*15
DR16 HLA-DRB1*16
DR52 HLA-DRB3*01,*02,*03 DR3 DR3 HLA-DRB1*0306, *0307, *0312, *0314
DR17 HLA-DRB1*0301, *0304, *0305, *0310, *0311
DR18 HLA-DRB1*0302, *0303
DR5 DR5 HLA-DRB1*1204
DR11 HLA-DRB1*11
DR12 HLA-DRB1*12
DR6 DR6 HLA-DRB1*1329, *1416, *1417, *1418
DR13 HLA-DRB1*13
DR14 HLA-DRB1*14
DR1403 HLA-DRB1*1403
DR1404 HLA-DRB1*1404
DR53 HLA-DRB4*01 DR4 DR4 HLA-DRB1*04
DR7 DR7 HLA-DRB1*07
DR9 DR9 HLA-DRB1*09
none - (1) DR8 DR8 HLA-DRB1*08, *1415


IMGT note:
  1. (1) A dash indicates the absence of the HLA-DRB3/4/5 gene.