By homology with the IG and TR V-DOMAINs, the limits of the putative CDR3-IMGT are shown.
___________________________________________________________________________________________________________________________________ Accession Allele EXON 1 number name ___________________________________________________________________________________________________________________________________ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Q P M V H Q P P S A S S S L G A T I R X05563 , VPREB2*01 CAG CCC ATG GTG CAT CAG CCA CCA TCA ... GCA TCT TCT TCC CTT GGA GCC ACC ATC CGC ___________________CDR1-IMGT____________________ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 L S C T L S N D H N I G I Y S I Y X05563 , VPREB2*01 CTC TCC TGT ACC CTG AGC AAC GAC CAT AAC ATT GGC ATT TAC AGC ... ... ... ATT TAC _______________CDR2- 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 W Y Q Q R P G H P P R F L L R Y F S H S X05563 , VPREB2*01 TGG TAC CAG CAG AGG CCG GGC CAC CCT CCC AGG TTC CTG CTG AGA TAC TTC TCA CAC TCA IMGT________________ 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 D K H Q G P D I P P R F S G S K X05563 , VPREB2*01 GAC AAG ... ... ... CAC CAG GGT CCC GAT ATC CCA ... CCT CGC TTC TCC GGG TCC AAA 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 D T A R N L G Y L S I S E L Q P E D E A X05563 , VPREB2*01 GAT ACG GCC AGG AAC CTG GGG TAT CTG AGC ATC TCT GAA CTG CAG CCT GAG GAC GAG GCT ______________CDR3-IMGT________________________________ 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 V Y Y C A V G L R S Q E K K R M E R E W X05563 , VPREB2*01 GTG TAT TAC TGC GCT GTG GGG CTC CGG AGC CAG GAA AAG AAG AGA ATG GAG AGA GAG TGG 121 122 123 124 125 126 127 128 129 130 131 E G E K S Y T D L G S * X05563 , VPREB2*01 GAA GGA GAA AAG TCG TAT ACA GAT TTG GGA TCT