1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Q P V L H Q P S A M S S A L G T T I R IMGT000062 VPREB1*01 F V-LIKE gDNA cag ccg gtg ctg cat cag ccg tcg gcc ... atg tcc tca gcc ctt gga acc aca atc cgc P NW_001095158 VPREB1*02 F V-LIKE gDNA --- --- --- --- --- --- --- c-- --- ... --- --- --- --- --- --- --- --- --- --- ____________________BC-LOOP_____________________ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 L T C T L R N D H D I S V Y S V Y IMGT000062 VPREB1*01 F V-LIKE gDNA ctc acc tgc acc ctg agg aac gac cat gac atc ... ... ... agt gtg tac agc gtc tac I NW_001095158 VPREB1*02 F V-LIKE gDNA --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- a-- --- _______________C'C"- 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 W Y Q Q R P G H P P R F L L R Y F S Q IMGT000062 VPREB1*01 F V-LIKE gDNA tgg tac cag cag agg ccg ggc cac cct ccg agg ttc ctg ctg agg tac ttc tca cag ... NW_001095158 VPREB1*02 F V-LIKE gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --a --- --- --- --- ... LOOP________________ 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 S D K S Q G P Q V P P R F S G S K IMGT000062 VPREB1*01 F V-LIKE gDNA ... ... tca gac aag agc cag ggc ccc cag gta ccc ... cct cgc ttc tct gga tcc aaa NW_001095158 VPREB1*02 F V-LIKE gDNA ... ... --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 D V A G N K G Y L N I A E L Q P E D E A IMGT000062 VPREB1*01 F V-LIKE gDNA gat gtg gcc ggg aac aag ggg tat ttg aac atc gct gag cta cag cct gag gac gag gct NW_001095158 VPREB1*02 F V-LIKE gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ______________________FG-LOOP_______________________ 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 M Y Y C A M G A R S F E K K E R E R E W IMGT000062 VPREB1*01 F V-LIKE gDNA atg tat tac tgt gct atg ggg gcc cgc agc ttc gag aag aag gag agg gag agg gag tgg NW_001095158 VPREB1*02 F V-LIKE gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 121 122 123 124 125 126 127 128 129 130 131 132 133 134 E E E M E P T A A G T P V P IMGT000062 VPREB1*01 F V-LIKE gDNA gag gaa gaa atg gaa ccc act gca gcc ggg aca cct gtc cct NW_001095158 VPREB1*02 F V-LIKE gDNA --- --- --- --- --- --- --- --- --- --- --- --- --- ---