IMGT Repertoire (RPI)


              <———————— L-REGION ———————> <————————————— V-LIKE-DOMAIN —————————————
                                                     FR1-IMGT           CDR1-IMGT
                                                      (1-26)             (27-38)
                                                A             B            BC
                                              (1-15)       (16-26)       (27-38)
                                          —————————————>  ——————————>
                                          1       10   15 16    23 26 27        38
                                          |........|....| |......|..| |....°°....|
   Oncmyk     MNVYWIPTILLS..LSSAANMISSNN  CKDKLRTFYVVRVSV NGIASVRCPNL TGKD...QEEMR
   Salsal     MNVYWIPTILLSLCLSSAANMISSHN  YKDKLRTFNVVHVSV NGTASVRCPNL TGKD...QEEMR
   Danrer            MSSMTILTLELNKSNRDLL  TESAGELPLIEYVPL NSTVKVACPKL SAP......EMD
   Takrub        MLEANEAIWLYSFRDKKSIGGYE  NANRKNRLNTVCVPV GGNVNVPCPNS SAE......DIK
   Orylat              MAGFCWTLLVLMLSRTS  HTSHASQGLDTKDVT LKRVFVLCPNF TTQ......HVL
   Epicoi          MRACLVFVILLGCRFSHAIES  QSVCKDQLKIACVAP GHNVSVPCPKL TTQ......DVT
   Xentro                                  /DSSETQQQVVLVA VKQIEITFPSN FKDN....KESR
   Galgal              MLGILVVLCLIPAADVT  ENKILVAQRPLLIVA NRTATLVCNYT YNGT...GKEFR
   Homsap            M.LRLL.LALNLFPSIQVT(G)NKILVKQSPMLVAY DNAVNLSCKYS YNLF...SREFR
   Musmus            MTLRLLFLALN.FFSVQVT(E)NKILVKQSPLLVVD SNEVSLSCRYS YNLL...AKEFR


                   ————————————————————————— V-LIKE-DOMAIN —————————————————————————
                         FR2-IMGT       CDR2-IMGT                    FR3-IMGT
                         (39-55)         (56-65)                     (66-104)
                      C         C'         C'C''        C''       D           E
                   (39-46)    (47-55)    (56-65)     (66-74)   (75-84)     (85-96)
                   ——————>   ————————>               ———————>  ————————>  ——————————>
                   3941  46  47     55 56   AB   65 66     74 75   80 84 85  89    96
                   |.|....|AB|.......| |....°°....| |.......| |....|...|A|...|......|
   Oncmyk	   FHLYLGL....VEVGNHTH DSAHN..HNSTE TVSPVGE.. GLGLRVNEQD.HTVSFVLSGMTT
   Salsal	   FHLYLGL....VEVGNHTH DNAHN..HNSTE TVSPVGE.. GLGLRVNKQD.HTVSFVLSGMTT
   Danrer	   FRLFKDG....DEISIYVK INHT.....SIP KTNTNKE.. FPAEFSVDLD.NSSSFILTVVTV
   Takrub	   FSLFKDG....ECVHHHTQ ISG.......AT TPNQNTS.. NPVGVEYPSA.NSPNFTITGVNA
   Tetnig	                                   /GPPRTNT.. VGVEFKGPEN.GSYSFVLPGANA
   Orylat	   FKLTINQ....ELMATCEI.KNS.......SQ IFESQPS.. NTDVEFKKTD.ALVGFELRGAMA
   Epicoi	   FYLLKEE....EVIYKLAC.MRNN....ATSD CEQSNTGV. GVELQENTEN.KSASFTLTGVNA
   Xentro	   VSLLRGV....KKSITVCS GSFNS..SYQSF ESNAYQS.. .IRCIGIPTE.NKITFHLSGLTE
   Galgal	   ASLHKGT....DSAVEVCF ISWN....MTKI NSNSNKE.. .FNCRGIHDK.DKVIFNLWNMSA
   Homsap	   ASLHKGL....DSAVEVCV VYGNY...SQQL QVYSKTG.. .FNCDGKLGN.ESVTFYLQNLYV
   Musmus	   ASLYKGV....NSDVEVCV GNGNF...TYQP QFRSNAE.. .FNCDGDFDN.ETVTFRLWNLHV


                   —————————— V-LIKE-DOMAIN —————————> <————— CONNECTING-REGION —————>
                   FR3-IMGT    CDR3-IMGT    FR4-IMGT
                   (66-104)    (105-117)   (118-126)
                      F           FG           G
                   (97-104)    (105-117)   (118-126)
                    ——————>                ————————>
                   97   104 105  111  117 118     128
                   |......| |.....|.....| |.........|
   Oncmyk	   ERAGVYTC EGYPMYPPPIEKV PDEPQTLVLVE .AFQCQAG...GCVGPRVHGVP.........
   Salsal	   ERAGVYTC EGHPMYPPPIEKV PDEPQTLVLVE .ALQCQARKTVGCEGSGDDGVP.........
   Danrer	   NMTALYTC EASISYPPPFKYV DHKPQTIVFVE/
   Takrub	   SSHGIYTC EVTEMFPPPLMTL YSDLRILVLIE .GHQCSAKDKNPTIRENQTCGC.........
   Tetnig	   CSHGIYRC EGTVMFPPPLKPL PSTPAVLLLVE .GHQCSNGTDKSPEGDGTSGS..........
   Orylat	   RADVAYRC DADKKFPPPFESF PNHSWFLVFHE ..ETCTNPEACQEAGGGGGGQL.........
   Epicoi	   SSYGIYRC EVHIMFPPPLRKV PSTLSILVRVK .GHQCTVNETYIIKPAIEEAQKD........
   Xentro	   NHTDIYFF RKEDMYPPPYTCY QDNGTVIHVKE LVAPVKDPLPQPQW.................
   Galgal	   SQTDIYFC KIEAMYPPPYVYN EKSNGTVIHVR ETPIQTQEPESATS.................
   Homsap	   NQTDIYFC KIEVMYPPPYLDN EKSNGTIIHVK GKHLCPSPLFPGPSKP...............
   Musmus	   NHTDIYFC KIEFMYPPPYLDN ERSNGTIIHIK EKHLCHTQSSPEL..................


                   <—————————— TM —————————> <———————————————— IC ————————————————————>
   Oncmyk          VWAWMLGFWVTTIYGLVVTVFAFVI WLRLRRVECSQSDYMDIKPKAPLRGHRKKQGVQHPIRMGRY*
   Salsal          AWVWVLGFWVTIIYGLAVTVIAFAI RLRLRRVECSQSDYMSAKPRAPLRWPRKKQGVQHPIRMGRY*
   Takrub          GWMWIFAL.VIGSYSVTVTIGAIII WVKWRRED.SQSDYINTISKTTRYNKRK...LHIPTMHYFYAPN*
   Tetnig          DWLWILTL.MVSTYGVAVTIGAVFI WVKWRKDD.SQSAYVNTNPKTTRSKGRL....YNPKPHFFYAPD*
   Orylat          LWVWVTGVTLLATYGLAVTVAAFVL WXKLKDAD.SQNDYMNTKPKA....ARKRRGLQNPTPKYV*
   Epicoi          LWIWILGIVVLGVYGIIVTIVAIII WAKWRQSD.SQCDYMNTKPKA.TRDRKKKRGVQIPIPRHF*
   Xentro          GFPLLVAIGVMAAYSLTITAAFFYI LKKGRRTRVLQSEYINVVPRRPK....CHQPYAPAPVHCRPR*
   Galgal          YWVMVAVTGLLGFYSMLITAVFIIY RQKSKRNRYRQSDYMNMTPRHPPHQKNKGYPSYAPTRDYTAYRSWQP*
   Homsap          FWVLVVVGGVLACYSLLVTVAFIIF WVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS*
   Musmus          FWALVVVAGVLFCYGLLVTVALCVI WTNSRRNRLLQSDYMNMTPRRPGLTRKPYQPYAPARDFAAYRP*

Legend:

Danrer: Danio rerio (Zebrafish): Ensembl assembly v36 chromosome 1_31827149-31832280
Epicoi: Epinephelus coioides (Orange-spotted grouper, Estuary rock cod): dr711304
Galgal: Gallus gallus (Chicken): Ensembl v36 ENSGALG00000008669
Homsap: Homo sapien (Human): ENSG00000178562
Musmus: Mus musculus (House mouse): ENSMUSG00000026012
Oncmyk: Oncorhynchus mykiss (Rainbow trout): AY789435
Orylat: Oryzia latipes(Japanese medaka): scaffold299_contig73_4766-7696, scaffold114_47889-50819, ESTs bj016306, bj517516, bj495736, bj496049
Takrub: Takifugu rubripes (Torafugu): Ensembl v36 scaffold_32; 299270-305349
Tetnig: Tetraodon nigroviridis (Spotted green pufferfish)
Salsal: Salmo salar (Atlantic salmon): ca369939, ca059267, ca064339, ca062851, ca053916, ca769496, ca057139
Xentro: Xenopus tropicalis (Western clawed frog): Ensembl v36 scaffold_203

Figure in pdf from [1]: Residues of the ligand-binding site (V-LIKE-DOMAIN) and residues of the potential signaling sites (IC region) are bold. Relevant conserved positions are shadowed.

[1]	Bernard D. et al., Dev. Comp. Immunol. 31, 255-271 (2007). PMID: 16928399
[2]	Lefranc M.-P. et al., Dev. Comp. Immunol., 29, 185-203 (2005) PMID: 15572068 with permission from Elsevier

IMGT Repertoire (RPI)

Protein display: V-LIKE-DOMAIN (proteins other than IG or TR) CD28 and CD28 related sequences