<———————— L-REGION ———————> <————————————— V-LIKE-DOMAIN ————————————— FR1-IMGT CDR1-IMGT (1-26) (27-38) A B BC (1-15) (16-26) (27-38) —————————————> ——————————> 1 10 15 16 23 26 27 38 |........|....| |......|..| |....°°....| Oncmyk MNVYWIPTILLS..LSSAANMISSNN CKDKLRTFYVVRVSV NGIASVRCPNL TGKD...QEEMR Salsal MNVYWIPTILLSLCLSSAANMISSHN YKDKLRTFNVVHVSV NGTASVRCPNL TGKD...QEEMR Danrer MSSMTILTLELNKSNRDLL TESAGELPLIEYVPL NSTVKVACPKL SAP......EMD Takrub MLEANEAIWLYSFRDKKSIGGYE NANRKNRLNTVCVPV GGNVNVPCPNS SAE......DIK Orylat MAGFCWTLLVLMLSRTS HTSHASQGLDTKDVT LKRVFVLCPNF TTQ......HVL Epicoi MRACLVFVILLGCRFSHAIES QSVCKDQLKIACVAP GHNVSVPCPKL TTQ......DVT Xentro /DSSETQQQVVLVA VKQIEITFPSN FKDN....KESR Galgal MLGILVVLCLIPAADVT ENKILVAQRPLLIVA NRTATLVCNYT YNGT...GKEFR Homsap M.LRLL.LALNLFPSIQVT(G)NKILVKQSPMLVAY DNAVNLSCKYS YNLF...SREFR Musmus MTLRLLFLALN.FFSVQVT(E)NKILVKQSPLLVVD SNEVSLSCRYS YNLL...AKEFR ————————————————————————— V-LIKE-DOMAIN ————————————————————————— FR2-IMGT CDR2-IMGT FR3-IMGT (39-55) (56-65) (66-104) C C' C'C'' C'' D E (39-46) (47-55) (56-65) (66-74) (75-84) (85-96) ——————> ————————> ———————> ————————> ——————————> 3941 46 47 55 56 AB 65 66 74 75 80 84 85 89 96 |.|....|AB|.......| |....°°....| |.......| |....|...|A|...|......| Oncmyk FHLYLGL....VEVGNHTH DSAHN..HNSTE TVSPVGE.. GLGLRVNEQD.HTVSFVLSGMTT Salsal FHLYLGL....VEVGNHTH DNAHN..HNSTE TVSPVGE.. GLGLRVNKQD.HTVSFVLSGMTT Danrer FRLFKDG....DEISIYVK INHT.....SIP KTNTNKE.. FPAEFSVDLD.NSSSFILTVVTV Takrub FSLFKDG....ECVHHHTQ ISG.......AT TPNQNTS.. NPVGVEYPSA.NSPNFTITGVNA Tetnig /GPPRTNT.. VGVEFKGPEN.GSYSFVLPGANA Orylat FKLTINQ....ELMATCEI.KNS.......SQ IFESQPS.. NTDVEFKKTD.ALVGFELRGAMA Epicoi FYLLKEE....EVIYKLAC.MRNN....ATSD CEQSNTGV. GVELQENTEN.KSASFTLTGVNA Xentro VSLLRGV....KKSITVCS GSFNS..SYQSF ESNAYQS.. .IRCIGIPTE.NKITFHLSGLTE Galgal ASLHKGT....DSAVEVCF ISWN....MTKI NSNSNKE.. .FNCRGIHDK.DKVIFNLWNMSA Homsap ASLHKGL....DSAVEVCV VYGNY...SQQL QVYSKTG.. .FNCDGKLGN.ESVTFYLQNLYV Musmus ASLYKGV....NSDVEVCV GNGNF...TYQP QFRSNAE.. .FNCDGDFDN.ETVTFRLWNLHV —————————— V-LIKE-DOMAIN —————————> <————— CONNECTING-REGION —————> FR3-IMGT CDR3-IMGT FR4-IMGT (66-104) (105-117) (118-126) F FG G (97-104) (105-117) (118-126) ——————> ————————> 97 104 105 111 117 118 128 |......| |.....|.....| |.........| Oncmyk ERAGVYTC EGYPMYPPPIEKV PDEPQTLVLVE .AFQCQAG...GCVGPRVHGVP......... Salsal ERAGVYTC EGHPMYPPPIEKV PDEPQTLVLVE .ALQCQARKTVGCEGSGDDGVP......... Danrer NMTALYTC EASISYPPPFKYV DHKPQTIVFVE/ Takrub SSHGIYTC EVTEMFPPPLMTL YSDLRILVLIE .GHQCSAKDKNPTIRENQTCGC......... Tetnig CSHGIYRC EGTVMFPPPLKPL PSTPAVLLLVE .GHQCSNGTDKSPEGDGTSGS.......... Orylat RADVAYRC DADKKFPPPFESF PNHSWFLVFHE ..ETCTNPEACQEAGGGGGGQL......... Epicoi SSYGIYRC EVHIMFPPPLRKV PSTLSILVRVK .GHQCTVNETYIIKPAIEEAQKD........ Xentro NHTDIYFF RKEDMYPPPYTCY QDNGTVIHVKE LVAPVKDPLPQPQW................. Galgal SQTDIYFC KIEAMYPPPYVYN EKSNGTVIHVR ETPIQTQEPESATS................. Homsap NQTDIYFC KIEVMYPPPYLDN EKSNGTIIHVK GKHLCPSPLFPGPSKP............... Musmus NHTDIYFC KIEFMYPPPYLDN ERSNGTIIHIK EKHLCHTQSSPEL.................. <—————————— TM —————————> <———————————————— IC ————————————————————> Oncmyk VWAWMLGFWVTTIYGLVVTVFAFVI WLRLRRVECSQSDYMDIKPKAPLRGHRKKQGVQHPIRMGRY* Salsal AWVWVLGFWVTIIYGLAVTVIAFAI RLRLRRVECSQSDYMSAKPRAPLRWPRKKQGVQHPIRMGRY* Takrub GWMWIFAL.VIGSYSVTVTIGAIII WVKWRRED.SQSDYINTISKTTRYNKRK...LHIPTMHYFYAPN* Tetnig DWLWILTL.MVSTYGVAVTIGAVFI WVKWRKDD.SQSAYVNTNPKTTRSKGRL....YNPKPHFFYAPD* Orylat LWVWVTGVTLLATYGLAVTVAAFVL WXKLKDAD.SQNDYMNTKPKA....ARKRRGLQNPTPKYV* Epicoi LWIWILGIVVLGVYGIIVTIVAIII WAKWRQSD.SQCDYMNTKPKA.TRDRKKKRGVQIPIPRHF* Xentro GFPLLVAIGVMAAYSLTITAAFFYI LKKGRRTRVLQSEYINVVPRRPK....CHQPYAPAPVHCRPR* Galgal YWVMVAVTGLLGFYSMLITAVFIIY RQKSKRNRYRQSDYMNMTPRHPPHQKNKGYPSYAPTRDYTAYRSWQP* Homsap FWVLVVVGGVLACYSLLVTVAFIIF WVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS* Musmus FWALVVVAGVLFCYGLLVTVALCVI WTNSRRNRLLQSDYMNMTPRRPGLTRKPYQPYAPARDFAAYRP*
[1] | Bernard D. et al., Dev. Comp. Immunol. 31, 255-271 (2007). PMID: 16928399 |
[2] | Lefranc M.-P. et al., Dev. Comp. Immunol., 29, 185-203 (2005) PMID: 15572068 with permission from Elsevier |