IMGT Repertoire (RPI)

Protein displays: V-LIKE-DOMAINs (proteins other than IG or TR) CTLA4 and CTLA4 related sequences

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Citing this figure: Bernard D., Hansen J.D., Du Pasquier L., Lefranc M.-P., Benmansour A. and Boudinot P. "Costimulatory receptors in non mammalian vertebrates: conserved CD28, odd CTLA4 and multiple BTLAs" Dev. Comp. Immunol. 31, 255-271 (2007) PMID: 16928399 [1]


                                            <———————————— L-REGION ————————————>
    Oncmyk                                                    MTLSLLTFLCLGLCLPVW
    Orylat                                                MVVADCVFGWRMLTVLGVCLPL
    Danrer
    Xentro                                                    MMRIPFITGIFCLITNAS
    Xentro2
    Galgal
    Homsap                                  MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCK
    Musmus                                  MACLGLRRYKAQLQLPSRTWPFVALLTLLFIPVFSE


                                        <————————————— V-LIKE-DOMAIN —————————————
                                                   FR1-IMGT           CDR1-IMGT
                                                    (1-26)             (27-38)
                                              A             B            BC
                                            (1-15)       (16-26)       (27-38)
                                        —————————————>  ——————————>
                                        1       10   15 16    23 26 27        38
                                        |........|....| |......|..| |....°°....|
    Oncmyk                              NALRVTQPY.RVVSH RGEVELFCSYH HTGRN.EPEELR
    Orylat                              YSAVKVVQP.RVEST NGTARIRCTFH PEMN...LEDLR
    Danrer                                                 /SMHCSFR SKLRP.EEVQVS
    Xentro                              GLKVTQPDI.IVANR HGKAMLVCDYR IHAK...VEEMR
    Xentro2                              /SKSYPKV.VIASQ DGEPCLLCHHV PSTD...SKFNL
    Galgal                              /MEVTQPAI.VLANR QGVASLVCNYK HIGN...AKEIR
    Homsap                              AMHVAQPAV.VLASS RGIASFVCEYA SPGK...ATEVR
    Musmus                              AIQVTQPSV.VLASS HGVASFPCEYS PSHN...TDEVR


                ————————————————————————— V-LIKE-DOMAIN —————————————————————————
                      FR2-IMGT       CDR2-IMGT                    FR3-IMGT
                      (39-55)         (56-65)                     (66-104)
                   C         C'         C'C''        C''      D           E
                (39-46)    (47-55)    (56-65)     (66-74)   (75-84)     (85-96)
                ——————>   ————————>               ———————>  ————————>  ——————————>
                3941  46  47     55 56   AB   65 66     74 75   80 84 85  89    96
                |.|....|AB|.......| |....°°....| |.......| |....|...|A|...|......|A
    Oncmyk      ITLYRGMYGEQEE.QKVCT SSFTH...NNTA FQVEGEGER KVRCRGQLRP.GKVNLTISGLRG.
    Salsal                                                 /VTCRGQLGP.GKVNLTISGLRG.
    Orylat      VTLLRGL...HGH.QELCS FFLNL...TGQT ETHGGRP.. .GQCSGQTAD.GAVEV.L.DLKA.
    Danrer      VYKALH.....GH.ERICS AYVNL...SEPY FATDGP... .VRCRGNINF.GGVDLIIAGLRG.
    Xentro      FRLLRKMG..NQV.KEICA FSYST...NYES VTTGDA... .IQCEGEPGP.NNVTLHLSGMQM.
    Xentro2     TLMRGN.....KK.QEVCM VYTDG...KNTS FYSWNDN.. .PKCNWTKSN.DSSISFTLSNFDI
    Galgal      VTLLKQTG..DKF.TEICA STYTT...EFKM FSVEEV... .IQCHVSPSR.NNVTLTLTGLQA.
    Homsap      VTVLRQAD..SQV.TEVCA ATYMM...GNEL TFLDDS... ..ICTGTSSG.NQVNLTIQGLRA.
    Musmus      VTVLRQTN..DQM.TEVCA TTFTE...KNTV GFLDYP... ..FCSGTFNE.SRVNLTIQGLRA.


                —————————— V-LIKE-DOMAIN —————————> <————— CONNECTING-REGION —————>
                FR3-IMGT    CDR3-IMGT    FR4-IMGT
                (66-104)    (105-117)   (118-126)
                   F           FG           G
                (97-104)    (105-117)   (118-126)
                 ——————>                ————————>
                97   104 105  111  117 118     128
                |......| |.....|.....| |.........|
    Oncmyk      NDTDLYRC AIEVLYPPPYLRT FGNGTLLYIT. EEPGCFTPEAQRRDDVTGETSVRLP......
    Salsal      NDTDLYRC AIEVLYPPPYLRT FGNGTLLYIT. EEPGCFTPEAQRRDDITGETSVRLP......
    Orylat      ADTDVYRC KIQTFYPPPYLQL TGNGTLIHVI. EHPDCPSVNAQRRHEVEGEKEATLA......
    Danrer      EDTDVYRC EIEILFPPPYLRA LGNGTVVYIQ. EIPNCLTAHNASTQSQRQSKSQTSDRETVEN
    Xentro      SDTGMYIC KLDIMYPPPYRTT EGNGTLIYVSD LMSECAQSIEPPEFI................
    Xentro2     KHTDNYTC EIRIFYPPPFRSI IINETYVYIH/
    Galgal      NDTGLYVC KMERMYPPPYFMN KGNGTQLYVID .PEPCPDTA......................
    Homsap      MDTGLYIC KVELMYPPPYYLG IGNGTQIYVID .PEPCPDSD......................
    Musmus      VDTGLYLC KVELMYPPPYFVG MGNGTQIYVID .PEPCPDSD......................


                <—————————— TM —————————> <—————————————————— IC —————————————————————>
    Oncmyk      LAGL..AAVLIVISAIAILLVHQVL QRKRRFEAIVPMMSKNDGRFDYGNFQ*
    Salsal      LAGMTAATILIVISAIAILLVHQVL QRKRRFEAIIPMTSQNDGRFDYGNFQ*
    Orylat      AASTPVAVLVTVIICVLVIIIY..L QVVRTNIKVVDR.SNSEKVHEHLFLRGCREQQVVSNNYPTHSSV*
    Danrer      DIGPLLLLYIILIITSCSFFLQIAI CKWRTSSSMAPMLSQKESYVKF*
    Xentro      LDQRILLVVCLVMFLYSMFITAVLL ..CGKQRKKFTVGNYEKM..LESDQGNGFSPYYIRVN*
    Galgal      TYLWVLGATASGFFLYSIIISAIVV GKAIQRRQRLTTGVYVKMPSEKLEKKVI..PFHITV*
    Homsap      FLLWILAAVSSGLFFYSFLLTAVSL SKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN*
    Musmus      FLLWILVAVSLGLFFYSFLVTAVSL SKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN*

Legend:

Danrer: Danio rerio (Zebrafish): Ensembl assembly v36 chromosome 9, 16772109-16789355 and ESTs bj016306, bj517516, bj495736 and bj496049
Galgal: Gallus gallus (Chicken): Ensembl v36 chromosome C
Homsap: Homo sapien (Human): ENSG00000163599
Musmus: Mus musculus (House mouse): ENSMUSG00000026011
Oncmyk: Oncorhynchus mykiss (Rainbow trout): AY789436<
Orylat: Oryzia latipes(Japanese medaka): scaffold3303 and EST GOLWno4565_h05.b1
Salsal: Salmo salar (Atlantic salmon): CA044588
Xentro: Xenopus tropicalis (Western clawed frog): Ensembl v36 scaffold_203
Xentro2: Corresponds to a Xenopus sequence similar to both CTLA4 and ICOS; Ensembl v36 scaffold_168

Figure in pdf from [1]: Residues of the ligand-binding site (V-LIKE-DOMAIN) and residues of the potential signaling sites (IC region) are bold. Relevant conserved positions are shadowed.

References:
[1]	Bernard D. et al., Dev. Comp. Immunol. 31, 255-271 (2007). PMID: 16928399
[2]	Lefranc M.-P. et al., Dev. Comp. Immunol., 29, 185-203 (2005) PMID: 15572068 with permission from Elsevier

See also:

IMGT Scientific chart:
- The protein display is according to the IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN [2].
- Colors are according to IMGT color menu for genes.

Created: 13/02/2007
Last updated: Wednesday, 12-Jun-2024 16:02:45 CEST
Authors: Elodie Gemrot, Pierre Boudinot, Vijay Phani Garapati and Marie-Paule Lefranc
Editors: Elodie Gemrot and Chantal Ginestoux