IMGT Repertoire (RPI)

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Other CD3 entries

Homo sapiens: CD3E, CD3G
Mus musculus: CD3D, CD3E, CD3G

IMGT RPI entry from gene to protein for Homo sapiens CD3D

Citing IMGT RPI entry for CD3D

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens CD3D
IMGT gene definition: CD3D antigen, delta polypeptide (TiT3 complex)

Chromosomal localization

Chromosome: 11
Chromosomal localization: 11q23.3

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 1

IMGT reference alleles

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
CD3D*01	F	EX1-5	X03934	gDNA

IMGT reference sequences (in FASTA format) for the allele(s): CD3D*01

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Clone names	Exons	Accession numbers	Molecule type
CD3D*01	F	pKR-1	EX1	M12726	gDNA
		pKR-1	EX2-EX5	M12727
			EX1-EX5	X01451
		MGC:88324	EX1-EX5	BC070321	cDNA
		MGC:47775	EX1-EX5	BC039035
			EX1-EX5	NM_000732

Corresponding protein database accession numbers

Allele names	Accession numbers		Number of amino acids	Protein isoform
Allele names	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
CD3D*01	X03934	P04234	171 aa	1
CD3D*01	NM_000732	NP_000723

IMGT references:

[1] Tunnacliffe A. et al. EMBO J. 5, 1245-1252 (1986). PMID:3488209

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD3D*01: X03934(g)

Nucleotide sequence

1        atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc

61       cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc

121      atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg

181      ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag

241      gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat

301      ccagccaccg tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg

361      ggagtcttct gctttgctgg acatgagact ggaaggctgt ctggggctgc cgacacacaa

421      gctctgttga ggaatgacca ggtctatcag cccctccgag atcgagatga tgctcagtac

481      agccaccttg gaggaaactg ggctcggaac aagtga

Nucleotide sequence in FASTA format (without gaps) CD3D*01

Amino acid sequence

1        MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT LLSDITRLDL

61       GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVELD PATVAGIIVT DVIATLLLAL

121      GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ PLRDRDDAQY SHLGGNWARN K*

Amino acid sequence in FASTA format (without gap) CD3D*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: C-LIKE-DOMAIN

IMGT databases

IMGT/3Dstructure-DB: 1xiw

External links

Nomenclature

HGNC: 1673

Genome databases

Entrez Gene: 915
GENATLAS: 80
GeneCards: GC11M117714
GDB: 120578
OMIM: 186790

Sequence databases

EMBL: X03934, X01451, M12726, M12727, BC070321, BC039035
GenBank: X03934, X01451, M12726, M12727, BC070321, BC039035
DDBJ: X03934, X01451, M12726, M12727, BC070321, BC039035
Swiss-Prot: P04234
TrEMBL:
NCBI: NM_000732, NP_000723

Structure databases

PDB: 1xiw