IMGT Repertoire (RPI)

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Other B7 Family entries

Homo sapiens: B7A1, B7H1, B7DC, B7H2, B7H3, B7H4
Mus musculus: B7A1, B7A2, B7H1, B7DC, B7H2, B7H3, B7H4

IMGT RPI entry from gene to protein for Homo sapiens B7A2

Citing IMGT RPI entry for B7A2

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens B7A2
IMGT gene definition: CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)

Chromosomal localization

Chromosome: 3
Chromosomal localization: 3q21

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 2

IMGT reference alleles

Allele names	Gene functionality	Clone names	IMGT reference sequences
Allele names	Gene functionality	Clone names	Exons	Accession numbers	Molecule type
B7A2*01	F		EX1	U17715 [1]	gDNA
			EX2	U17717
			EX3	U17718
			EX4	U17719
			EX5	U17720
			EX6	U17721
			EX7	U17722
B7A2*02	F		EX1-EX7	L25259 [2]	cDNA (1)
B7A2*02

IMGT reference sequences (in FASTA format) for the allele(s): B7A2*01 to B7A2*02

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
B7A2*02	F	EX1-EX7	EF064748	gDNA
			U04343	cDNA
			BC040261
			NM_005191
		EX2-EX7	CR541844	cDNA splicing B (3)
		EX2-EX7	NM_006889

Corresponding protein database accession numbers

Allele names	Accession numbers		Number of amino acids	Protein isoform
Allele names	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
B7A2*01	U17715		329 aa	1
	U17717		329 aa	1
	U17718		329 aa	1
	U17719		329 aa	1
	U17720		329 aa	1
	U17721		329 aa	1
	U17722		329 aa	1
B7A2*02	L25259	P42081	329 aa	1
	NM_005191	NP_008820	329 aa	1
	NM_006889	NP_787058	323 aa	2

IMGT notes:

(1) In EX3 [D1], g28>a; E10>K, positions are according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN.
(2) No EX1. Utilizes alterative start codon located 4 bases after 5' ACCEPTOR-SPLICE site in EX2.

IMGT references:

[1] Jellis,C.L., et al., Immunogenetics 42, 85-89 (1995). PMID:7541777
[2] Freeman,G.J., et al. Science 262, 909-911 (1993). PMID:7694363

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

B7A2*01: U17715(g) U17717(g) U17718(g) U17719(g) U17720(g) U17721(g) U17722(g)

Nucleotide sequence

1        atggatcccc agtgcactat gggactgagt aacattctct ttgtgatggc cttcctgctc

61       tctggtgctg ctcctctgga gattcaagct tatttcaatg agactgcaga cctgccatgc

121      caatttgcaa actctcaaaa ccaaagcctg agtgagctag tagtattttg gcaggaccag

181      gaaaacttgg ttctgaatga ggtatactta ggcaaagaga aatttgacag tgttcattcc

241      aagtatatgg gccgcacaag ttttgattcg gacagttgga ccctgagact tcacaatctt

301      cagatcaagg acaagggctt gtatcaatgt atcatccatc acaaaaagcc cacaggaatg

361      attcgcatcc accagatgaa ttctgaactg tcagtgcttg ctaacttcag tcaacctgaa

421      atagtaccaa tttctaatat aacagaaaat gtgtacataa atttgacctg ctcatctata

481      cacggttacc cagaacctaa gaagatgagt gttttgctaa gaaccaagaa ttcaactatc

541      gagtatgatg gtattatgca gaaatctcaa gataatgtca cagaactgta cgacgtttcc

601      atcagcttgt ctgtttcatt ccctgatgtt acgagcaata tgaccatctt ctgtattctg

661      gaaactgaca agacgcggct tttatcttca cctttctcta tagagcttga ggaccctcag

721      cctcccccag accacattcc ttggattaca gctgtacttc caacagttat tatatgtgtg

781      atggttttct gtctaattct atggaaatgg aagaagaaga agcggcctcg caactcttat

841      aaatgtggaa ccaacacaat ggagagggaa gagagtgaac agaccaagaa aagagaaaaa

901      atccatatac ctgaaagatc tgatgaagcc cagcgtgttt ttaaaagttc gaagacatct

961      tcatgcgaca aaagtgatac atgtttttaa

Nucleotide sequence in FASTA format (without gaps) B7A2*01

Amino acid sequence

1        MDPQCTMGLS NILFVMAFLL SGAAPLEIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ

61       ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM

121      IRIHQMNSEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI

181      EYDGIMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ

241      PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK

301      IHIPERSDEA QRVFKSSKTS SCDKSDTCF*

Amino acid sequence in FASTA format (without gap) B7A2*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: V-LIKE-DOMAIN, C-LIKE-DOMAIN

IMGT databases

IMGT/3Dstructure-DB: 1i85, 1ncn

External links

Nomenclature

HGNC: 1705

Genome databases

Entrez Gene: 942
GENATLAS: 3079
GeneCards: GC03P123256
GDB: 433597
OMIM: 601020

Sequence database

EMBL: U17715, U17717, U17718, U17719, U17720, U17721, U17722, L25259, DQ893787, EF064748, U04343, BC040261, CR541844
GenBank: U17715, U17717, U17718, U17719, U17720, U17721, U17722, L25259, DQ893787, EF064748, U04343, BC040261, CR541844
DDBJ: U17715, U17717, U17718, U17719, U17720, U17721, U17722, L25259, DQ893787, EF064748, U04343, BC040261, CR541844
Swiss-Prot: P42081
TrEMBL:
NCBI: NM_005191, NM_006889

Structure database

PDB: Ii85, 1ncn