IMGT Repertoire (RPI)

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Other CD2 Family entries

Homo sapiens: CD58, CD48, CD84, CD244, SLAMF1, SLAMF6, Ly9
Mus musculus: CD2, CD48, CD84, CD244, SLAMF1, SLAMF6, Ly9

IMGT RPI entry from gene to protein for Homo sapiens CD2

Citing IMGT RPI entry for CD2

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens CD2
IMGT gene definition: CD2 molecule

Chromosomal localization

Chromosome: 1
Chromosomal localization: 1p13

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 4

IMGT reference alleles

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
CD2*01	F	EX1-5	X07871 [1]	gDNA
CD2*02	F	EX1-5	M16445 [2]	cDNA (1)
CD2*03	F	EX1-5	M16336 [3]	cDNA (2)
CD2*04	F	EX1-5	AK223393	cDNA (3)

IMGT reference sequences (in FASTA format) for the allele(s): CD2*01 to CD2*04

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
CD2*01	F	EX1-5	M19806	gDNA
			AL135798	gDNA
			M14362	cDNA
CD2*02	F	EX1-5	BC033583	cDNA
CD2*02	F	EX1-5	NM_001767	cDNA

Corresponding protein database accession numbers

Allele names	Accession numbers		Number of amino acids	Protein isoform
Allele names	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
CD2*01	X07871	P06729	351 aa	1
CD2*02	M16445		351 aa	1
CD2*02	NM_001767	NP_001758	351 aa	1
CD2*03	M16336		360 aa	1
CD2*04	AK223393	Tr:Q53F96	351 aa	1

IMGT notes:

(1) In EX5 62c>a 21H>Q.
(2) 360 aa. In EX5, c276 is absent. This deletion in the ORF leads to frame shift and the translation continues 27 nt beyond the 3' DONOR-SPLICE site until the first STOP-CODON, in frame, in the down stream intron.
(3) In EX3 [D2] a117>g, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.

IMGT references:

[1] Lang G. et al, EMBO J. 7, 1675-1682 (1988). PMID:2901953
[2] Seed B. and Aruffo A. Proc. Natl. Acad. Sci. U.S.A. 84, 3365-3369 (1987). PMID:2437578
[3] Sayre P.H. et al, Proc. Natl. Acad. Sci. U.S.A. 84, 2941-2945 (1987). PMID:2883656

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD2*01: X07871(g)

Nucleotide sequence

1        atgagctttc catgtaaatt tgtagccagc ttccttctga ttttcaatgt ttcttccaaa

61       ggtgcagtct ccaaagagat tacgaatgcc ttggaaacct ggggtgcctt gggtcaggac

121      atcaacttgg acattcctag ttttcaaatg agtgatgata ttgacgatat aaaatgggaa

181      aaaacttcag acaagaaaaa gattgcacaa ttcagaaaag agaaagagac tttcaaggaa

241      aaagatacat ataagctatt taaaaatgga actctgaaaa ttaagcatct gaagaccgat

301      gatcaggata tctacaaggt atcaatatat gatacaaaag gaaaaaatgt gttggaaaaa

361      atatttgatt tgaagattca agagagggtc tcaaaaccaa agatctcctg gacttgtatc

421      aacacaaccc tgacctgtga ggtaatgaat ggaactgacc ccgaattaaa cctgtatcaa

481      gatgggaaac atctaaaact ttctcagagg gtcatcacac acaagtggac caccagcctg

541      agtgcaaaat tcaagtgcac agcagggaac aaagtcagca aggaatccag tgtcgagcct

601      gtcagctgtc cagagaaagg tctggacatc tatctcatca ttggcatatg tggaggaggc

661      agcctcttga tggtctttgt ggcactgctc gttttctata tcaccaaaag gaaaaaacag

721      aggagtcgga gaaatgatga ggagctggag acaagagccc acagagtagc tactgaagaa

781      aggggccgga agccccacca aattccagct tcaacccctc agaatccagc aacttcccaa

841      catcctcctc caccacctgg tcatcgttcc caggcaccta gtcatcgtcc cccgcctcct

901      ggacaccgtg ttcagcacca gcctcagaag aggcctcctg ctccgtcggg cacacaagtt

961      caccagcaga aaggcccgcc cctccccaga cctcgagttc agccaaaacc tccccatggg

1021     gcagcagaaa actcattgtc cccttcctct aattaa

Nucleotide sequence in FASTA format (without gaps) CD2*01

Amino acid sequence

1        MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE

61       KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK

121      IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL

181      SAKFKCTAGN KVSKESSVEP VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ

241      RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP

301      GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS N*

Amino acid sequence in FASTA format (without gap) CD2*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: V-LIKE-DOMAIN, C-LIKE-DOMAIN

IMGT databases

IMGT/3Dstructure-DB: 1cdb, 1gya, 1hnf

External links

Nomenclature

HGNC: 1639

Genome databases

Entrez Gene: 914
GENATLAS: 79
GeneCards: GC01P117009
GDB: 118735
OMIM: 186990

Sequence database

EMBL: X07871, M16445, M16336, M19806, AL135798, M14362, BC033583
GenBank: X07871, M16445, M16336, M19806, AL135798, M14362, BC033583
DDBJ: X07871, M16445, M16336, M19806, AL135798, M14362, BC033583
Swiss-Prot: P06729
TrEMBL: Q53F96
NCBI: NM_001767, NP_001758

Structure database

PDB: 1cdb, 1gya, 1hnf, 1l2z