IMGT Repertoire (RPI)

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Other CD2 family entries

Homo sapiens: CD2, CD58, CD48, CD244, SLAMF1, SLAMF6, Ly9
Mus musculus: CD2, CD48, CD84, CD244, SLAMF1, SLAMF6, Ly9

IMGT RPI entry from gene to protein for Homo sapiens CD84

Citing IMGT RPI entry for CD84

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens CD84
IMGT gene definition: CD84 antigen

Chromosomal localization

Chromosome: 1
Chromosomal localization: 1q24

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 1

IMGT reference alleles

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
CD84*01	F	EX1-8	AF054816	cDNA

IMGT reference sequences (in FASTA format) for the allele(s): CD84*01

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
CD84*01	F	EX1-8	Y12632	cDNA splicing B (1)
		EX1-7	U82988 [1]	cDNA splicing C (2)
			BC020063	cDNA
			AL138930	gDNA
		EX1-4c	U96627	cDNA splicing D (3)
		EX1-4, 7b	AF054817	cDNA splicing E (4)
		EX1-3b	AF054818	cDNA splicing F (5)

Corresponding protein database accession numbers

Allele names	Accession numbers		Number of amino acids	Protein isoform
Allele names	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
CD84*01	AF054816	Tr: Q9UIB8	345 aa	1
	Y12632	Tr: Q8WWI8	339 aa	2
	U82988	O15430	328 aa	3
	U96627	O95660	280 aa	4
	AF054817	Tr: Q9UIB7	272 aa	5
	AF054818	Tr: Q9UIB6	241 aa	6
	NM_003874	NP_003865	328 aa	3

IMGT notes:

(1) Splicing B (339 aa). Alternative splicing site in EX4 19 bp upstream of the normal 3' splice site.
(2) Splicing C (328 aa). Alternative splicing site in EX4 19 bp upstream of the normal 3' splice site and no EX5.
(3) Splicing D (280 aa). No splicing site in EX4, 83 bp extend beyond the normal site and terminate prematurely.
(4) Splicing E (272 aa). No EX5-6. This frame shift caus the premature termination with in EX7.
(5) Splicing F (241 aa). No 3' splice site in EX3. This cause the premature termination.

IMGT references:

[1] de la Funte MA. et al, Blood 90, 2398-2405 (1997). PMID:9310491

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD84*01: AF054816(c)

Nucleotide sequence

1        atggctcagc accacctatg gatcttgctc ctttgcctgc aaacctggcc ggaagcagct

61       ggaaaagact cagaaatctt cacagtgaat gggattctgg gagagtcagt cactttccct

121      gtaaatatcc aagaaccacg gcaagttaaa atcattgctt ggacttctaa aacatctgtt

181      gcttatgtaa caccaggaga ctcagaaaca gcacccgtag ttactgtgac ccacagaaat

241      tattatgaac ggatacatgc cttaggtccg aactacaatc tggtcattag cgatctgagg

301      atggaagacg caggagacta caaagcagac ataaatacac aggctgatcc ctacaccacc

361      accaagcgct acaacctgca aatctatcgt cggcttggga aaccaaaaat tacacagagt

421      ttaatggcat ctgtgaacag cacctgtaat gtcacactga catgctctgt agagaaagaa

481      gaaaagaatg tgacatacaa ttggagtccc ctgggagaag agggtaatgt ccttcaaatc

541      ttccagactc ctgaggacca agagctgact tacacgtgta cagcccagaa ccctgtcagc

601      aacaattctg actccatctc tgcccggcag ctctgtgcag acatcgcaat gggcttccgt

661      actcaccaca ccgggttgct gagcgtgctg gctatgttct ttctgcttgt tctcattctg

721      tcttcagtgt ttttgttccg tttgttcaag agaagacaag atgctgcctc aaagaaaacc

781      atatacacat atatcatggc ttcaaggaac acccagccag cagagtccag aatctatgat

841      gaaatcctgc agtccaaggt gcttccctcc aaggaagagc cagtgaacac agtttattcc

901      gaagtgcagt ttgctgataa gatggggaaa gccagcacac aggacagtaa acctcctggg

961      acttcaagct atgaaattgt gatctag

Nucleotide sequence in FASTA format (without gaps) CD84*01

Amino acid sequence

1        MAQHHLWILL LCLQTWPEAA GKDSEIFTVN GILGESVTFP VNIQEPRQVK IIAWTSKTSV

61       AYVTPGDSET APVVTVTHRN YYERIHALGP NYNLVISDLR MEDAGDYKAD INTQADPYTT

121      TKRYNLQIYR RLGKPKITQS LMASVNSTCN VTLTCSVEKE EKNVTYNWSP LGEEGNVLQI

181      FQTPEDQELT YTCTAQNPVS NNSDSISARQ LCADIAMGFR THHTGLLSVL AMFFLLVLIL

241      SSVFLFRLFK RRQDAASKKT IYTYIMASRN TQPAESRIYD EILQSKVLPS KEEPVNTVYS

301      EVQFADKMGK ASTQDSKPPG TSSYEIVI*

Amino acid sequence in FASTA format (without gap) CD84*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: V-LIKE-DOMAIN, C-LIKE-DOMAIN

External links

Nomenclature

HGNC: 1704

Genome databases

Entrez Gene: 8832
GENATLAS: CD84
GeneCards: GC01M158777
GDB: CD84
OMIM: 604513

Sequence database

EMBL: U82988, AF054815, AJ223324, BC020063, AF054816, Y12632, U96627, AF054817, AF054818
GenBank: U82988, AF054815, AJ223324, BC020063, AF054816, Y12632, U96627, AF054817, AF054818
DDBJ: U82988, AF054815, AJ223324, BC020063, AF054816, Y12632, U96627, AF054817, AF054818
Swiss-Prot: Q9UIB8
TrEMBL: Q96RX1
NCBI: NM_003874, NP_003865

Struture database

PDB: