IMGT Repertoire (RPI)

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Other CD8B entries

Homo sapiens: CD8A, CD8B
Mus musculus: CD8A

IMGT RPI entry from gene to protein for Mus musculus CD8B

Citing IMGT RPI entry for CD8B

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Mus musculus CD8B
IMGT gene definition: CD8B antigen, beta chain 1

Chromosomal localization

Chromosome: 6
Chromosomal localization: 6C1; 6 30.5 cM

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 3

IMGT reference alleles

Allele names	Gene functionality	Strain	IMGT reference sequences
Allele names	Gene functionality	Strain	Exons	Accession numbers	Molecule type
CD8B*01	F	B10.A	EX1	M26441 [1]	gDNA
			EX2	M26442
			EX3	M26443
			EX4	M26444
			EX5	M26445
			EX6	M26446
CD8B*02	F	C.AKR	EX1	M22065 [2]	gDNA (2)
			EX2	M22066
			EX3	M22067
			EX4	M22068
			EX5	M22069
			EX6	M22070
CD8B*03	F	NOD	EX1-6	AK087944	cDNA (3)

IMGT reference sequences (in FASTA format) for the allele(s): CD8B*01 to CD8B*03

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	Strain	IMGT reference sequences
Allele names	Gene functionality	Strain	Exons	Accession numbers	Molecule type
CD8B*01	F	BALB/c	EX1-6	M16799	cDNA
			EX1-6	M17534
			EX1-6	M19504
		C57BL/6J	EX1-6	AK162993
			EX1-6	AK169581
			EX1-6	X07698
			EX1-6	NM_009858
CD8B*02		NOD	EX1-6	AK088372	cDNA
			EX1-6	AK088649
			EX1-6	AK154055
			EX1-2, 5-6	U34882	cDNA (4) splicing B

Corresponding protein database accession numbers

Allele names	Accession numbers		Number of amino acids	Protein isoform
Allele names	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
CD8B*01	M26441	P10300	213 aa	1
	M26442		213 aa	1
	M26443		213 aa	1
	M26444		213 aa	1
	M26445		213 aa	1
	M26446		213 aa	1
	NM_009858	NP_033988	213 aa	1
CD8B*02	M22065		213 aa	1
	M22066		213 aa	1
	M22067		213 aa	1
	M22068		213 aa	1
	M22069		213 aa	1
	M22070		213 aa	1
CD8B*03	AK087944		213 aa	1

IMGT notes:

(1) In EX2[D] a225>c; R85>S, positiions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN.
(2) In EX2[D] a225>c; R85>S, positiions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN. In EX3 a58>c; K20>N.
(3) Splicing B (134 aa). This transcript has an inframe-splice site in EX2 3' region 45 bp up-stream to the normal splice site and in EX5 5' region 9 bp down-stream to the normal splice site. No EX3-4.

IMGT references:

[1] Nakayama K. et al, J. Immunol. 142, 2540-2546 (1989). PMID:2784466
[2] Youn H.J. Harriss J.V. and Gottlieb P.D. Immunogenetics 28, 353-361 (1988). PMID:3169881

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD8B*01: M26441(g) M26442(g) M26443(g) M26444(g) M26445(g) M26446(g)

Nucleotide sequence

1        atgcagccat ggctctggct ggtcttcagt atgaagctgg cagctctctg gagcagctct

61       gccctcattc agaccccttc gtccctgctg gttcaaacca accatacggc aaagatgtcc

121      tgtgaggtta aaagcatctc taagttaaca agcatctact ggctgcggga gcgccaggac

181      cccaaggaca agtactttga gttcctggcc tcctggagtt cttccaaagg agttttgtat

241      ggtgaaagtg tggacaagaa aagaaatata attcttgagt cttcagactc aagacggccc

301      tttctcagta tcatgaatgt gaagccagag gacagtgact tctacttctg cgcgacggtt

361      gggagcccca agatggtctt tgggacaggg acgaagctga ctgtggttga tgtccttcct

421      acaactgccc caaccaagaa gactaccctg aagatgaaga agaagaagca atgcccgttc

481      ccccacccag agacccagaa gggcctgaca tgcagcctta ccaccctcag cctgctggta

541      gtctgcatcc tgcttctgct ggcattcctc ggagtggccg tctactttta ctgtgtgcgg

601      aggagagccc gaattcactt catgaaacag tttcacaaat ga

Nucleotide sequence in FASTA format (without gaps) CD8B*01

Amino acid sequence

1        MQPWLWLVFS MKLAALWSSS ALIQTPSSLL VQTNHTAKMS CEVKSISKLT SIYWLRERQD

61       PKDKYFEFLA SWSSSKGVLY GESVDKKRNI ILESSDSRRP FLSIMNVKPE DSDFYFCATV

121      GSPKMVFGTG TKLTVVDVLP TTAPTKKTTL KMKKKKQCPF PHPETQKGLT CSLTTLSLLV

181      VCILLLLAFL GVAVYFYCVR RRARIHFMKQ FHK*

Amino acid sequence in FASTA format (without gap) CD8B*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: V-LIKE-DOMAIN

IMGT databases

IMGT/3Dstructure-DB: 2atp

External links

Nomenclature

HGNC:

Genome databases

Entrez Gene: 12526
MGI: 88347
GENATLAS:
GeneCards:
GDB:
OMIM:

Sequence databases

EMBL: M26441, M26442, M26443, M26444, M26445, M26446, M22065, M22066, M22067, M22068, M22069, M22070, AK087944, M16799, M17534, M19504, AK162993, AK169581, X07698, AK088372, AK088649, AK154055, U34882
GenBank: M26441, M26442, M26443, M26444, M26445, M26446, M22065, M22066, M22067, M22068, M22069, M22070, AK087944, M16799, M17534, M19504, AK162993, AK169581, X07698, AK088372, AK088649, AK154055, U34882
DDBJ: M26441, M26442, M26443, M26444, M26445, M26446, M22065, M22066, M22067, M22068, M22069, M22070, AK087944, M16799, M17534, M19504, AK162993, AK169581, X07698, AK088372, AK088649, AK154055, U34882
Swiss-Prot: P10300
TrEMBL: Q3TEK8, Q3TR81, Q8BH77, Q8C2U5, Q8K1B5, Q99JR4
NCBI: NM_009858, NP_033988

Structure database

PDB: 2atp