IMGT Repertoire (RPI)

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IMGT RPI entry from gene to protein for Homo sapiens KIR2DL2

Citing IMGT RPI entry for KIR2DL2

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens KIR2DL2
IMGT gene definition: Killer cell immunoglobulin-like receptor 2DL2

Chromosomal localization

Chromosome: 19
Chromosomal localization: 19q13.4

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 5

IMGT reference alleles

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
KIR2DL2*01	F	EX1-8	U24075 [1]	cDNA
KIR2DL2*02	F	EX1-8	L76669	cDNA (1)
KIR2DL2*03	F	EX1-8	AL133414	gDNA (2)
KIR2DL2*04	F	EX1-8	AY366242	cDNA (3)
KIR2DL2*05	F	EX2p, EX3-8	AF285433	cDNA (4)

IMGT reference sequences (in FASTA format) for the allele(s): KIR2DL2*01 to KIR2DL2*05

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
KIR2DL2*01	F	EX1-8	NM_014219	cDNA
KIR2DL2*03	F	EX2p, EX3-8	AF285434	cDNA (partial in 5')

Corresponding protein database accession numbers

Allele name	Accession numbers		Number of amino acids	Protein isoform
Allele name	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
KIR2DL2*01	U24075	P43627	348aa	1
KIR2DL2*01	NM_014219	NP_055034	348aa	1

IMGT notes:

(1) In EX7 t47>c; c50>g, S17>R; g51>c, E18>Q.
(2) In EX4 [D2] t380>c, I127>T, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN. In EX8 g127>a, A43>T
(3) In EX8 g127>a, A43>T.
(4) No EX1 and partial EX2. Has 16 nt differences compared to allele*01.

IMGT references:

[1] Wagtmann N. et al,Immunity 2 (5), 439-449 (1995).. PMID:7749980

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

KIR2DL2*01: AL133414(g) U24075(c)

Nucleotide sequence

1        atgtcgctca tggtcgtcag catggcgtgt gttgggttct tcttgctgca gggggcctgg

61       ccacatgagg gagtccacag aaaaccttcc ctcctggccc acccaggtcg cctggtgaaa

121      tcagaagaga cagtcatcct gcaatgttgg tcagatgtca ggtttgagca cttccttctg

181      cacagagaag ggaagtttaa ggacactttg cacctcattg gagagcacca tgatggggtc

241      tccaaagcca acttctccat cggtcccatg atgcaagacc ttgcagggac ctacagatgc

301      tacggttctg ttactcactc cccctatcag ttgtcagctc ccagtgaccc tctggacatc

361      gtcatcacag gtctatatga gaaaccttct ctctcagccc agccgggccc cacggttctg

421      gcaggagaga gcgtgacctt gtcctgcagc tcccggagct cctatgacat gtaccatcta

481      tccagggagg gggaggccca tgaatgtagg ttctctgcag ggcccaaggt caacggaaca

541      ttccaggccg actttcctct gggccctgcc acccacggag gaacctacag atgcttcggc

601      tctttccgtg actctccata cgagtggtca aactcgagtg acccactgct tgtttctgtc

661      ataggaaacc cttcaaatag ttggccttca cccactgaac caagctctaa aaccggtaac

721      ccccgacacc tgcacattct gattgggacc tcagtggtca tcatcctctt catcctcctc

781      ttctttctcc ttcatcgctg gtgctccaac aaaaaaaatg ctgcggtaat ggaccaagag

841      tctgcaggga acagaacagc gaatagcgag gactctgatg aacaagaccc tcaggaggtg

901      acatacacac agttgaatca ctgcgttttc acacagagaa aaatcactcg cccttctcag

961      aggcccaaga cacccccaac agatatcatc gtgtacgcgg aacttccaaa tgctgagtcc

1021     agatccaaag ttgtctcctg cccatga

Nucleotide sequence in FASTA format (without gaps) KIR2DL2*01

Amino acid sequence

1        MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVRFEHFLL

61       HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI

121      VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHECR FSAGPKVNGT

181      FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV IGNPSNSWPS PTEPSSKTGN

241      PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV

301      TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYAELPNAES RSKVVSCP*

Amino acid sequence in FASTA format (without gap) KIR2DL2*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: C-LIKE-DOMAIN [D1], [D2]

IMGT databases

IMGT/3Dstructure-DB: 2dl2, 2dli, 1efx

External links

Nomenclature

HGNC: 6330

Genome databases

Entrez Gene: 3803
GENATLAS: KIR2DL2
GeneCards: GC19P9H0021
GDB: KIR2DL2
OMIM: 604937

Sequence databases

EMBL: U24075, L76669, AF285433, AL133414, AF285434, AY366242
GenBank: U24075, L76669, AF285433, AL133414, AF285434, AY366242
DDBJ: U24075, L76669, AF285433, AL133414, AF285434, AY366242
Swiss-Prot: P43627
TrEMBL:
NCBI: NM_014219, NP_055034

Struture database

PDB: 2dl2, 2dlI, 1efx