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The database is composed of PDB 3D structure entries and INN/WHO 2D entries. IMGT/3Dstructure-DB provides a unique expertised resource on IG, TR, MHC and RPI with known 3D structures. Structural data are extracted from the Protein Data Bank PDB. The IMGT/3Dstructure-DB standardized information includes IMGT annotation on the sequences, 2D structures (IMGT Colliers de Perles) and 3D structures of IG, TR, MHC, and RPI with known 3D structures which are available in IMGT/3Dstructure-DB cards. In 2008, amino acid sequences from INN/WHO were entered in IMGT/2Dstructure-DB, a section of IMGT/3Dstructure-DB. They comprise those of monoclonal antibodies (IG, mAb) and fusion proteins for immune applications (FPIA).
HEADER COMPLEX (MHC/VIRAL PEPTIDE/RECEPTOR) 21-JUL-97 1AO7 TITLE COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), TITLE 2 AND HLA-A 0201 COMPND MOL_ID: 1; COMPND 2 MOLECULE: HLA-A 0201; COMPND 3 CHAIN: A; COMPND 4 FRAGMENT: EXTRACELLULAR DOMAINS ALPHA 1, ALPHA 2, ALPHA 3; COMPND 5 SYNONYM: HLA-A2 HEAVY CHAIN; COMPND 6 ENGINEERED: YES; COMPND 7 BIOLOGICAL_UNIT: HETERODIMER OF HEAVY CHAIN A AND BETA-2 COMPND 8 BETA-2 MICROGLOBULIN B; COMPND 9 MOL_ID: 2; COMPND 10 MOLECULE: BETA-2 MICROGLOBULIN; COMPND 11 CHAIN: B; COMPND 12 ENGINEERED: YES; COMPND 13 MUTATION: Y67C, K91C; COMPND 14 BIOLOGICAL_UNIT: HETERODIMER OF HEAVY CHAIN A AND BETA-2 COMPND 15 MICROGLOBULIN B; COMPND 16 MOL_ID: 3; COMPND 17 MOLECULE: TAX PEPTIDE; COMPND 18 CHAIN: C; COMPND 19 FRAGMENT: RESIDUES 11 - 19 FROM TAX PROTEIN OF HUMAN T COMPND 20 LYMPHOTROPIC VIRUS TYPE 1; COMPND 21 ENGINEERED: YES; COMPND 22 MOL_ID: 4; COMPND 23 MOLECULE: T CELL RECEPTOR ALPHA; COMPND 24 CHAIN: D; COMPND 25 FRAGMENT: EXTRACELLULAR DOMAINS V AND C, RESIDUES 1 - 212; COMPND 26 ENGINEERED: YES; COMPND 27 BIOLOGICAL_UNIT: ALPHA-BETA DIMER; COMPND 28 MOL_ID: 5; COMPND 29 MOLECULE: T CELL RECEPTOR BETA; COMPND 30 CHAIN: E; COMPND 31 FRAGMENT: EXTRACELLULAR DOMAINS V AND C, RESIDUES 1 - 246; COMPND 32 ENGINEERED: YES; COMPND 33 MUTATION: C191A; COMPND 34 BIOLOGICAL_UNIT: ALPHA-BETA DIMER SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 CELLULAR_LOCATION: PLASMA MEMBRANE; SOURCE 5 GENE: HLA-A 0201; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 7 EXPRESSION_SYSTEM_STRAIN: XA90; SOURCE 8 EXPRESSION_SYSTEM_CELLULAR_LOCATION: REFOLDED FROM SOURCE 9 INCLUSION BODIES; SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PHN1+; SOURCE 11 MOL_ID: 2; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_COMMON: HUMAN; SOURCE 14 CELLULAR_LOCATION: EXTRACELLULAR; SOURCE 15 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 16 EXPRESSION_SYSTEM_STRAIN: BL21 (DE3); SOURCE 17 EXPRESSION_SYSTEM_CELLULAR_LOCATION: REFOLDED FROM SOURCE 18 INCLUSION BODIES; SOURCE 19 EXPRESSION_SYSTEM_PLASMID: PLM1; SOURCE 20 MOL_ID: 3; SOURCE 21 SYNTHETIC: YES; SOURCE 22 ORGANISM_SCIENTIFIC: HUMAN T LYMPHOTROPIC VIRUS TYPE 1; SOURCE 23 ORGANISM_COMMON: HTLV-1; SOURCE 24 OTHER_DETAILS: RESIDUES 11-19 OF TAX PROTEIN; SOURCE 25 MOL_ID: 4; SOURCE 26 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 27 ORGANISM_COMMON: HUMAN; SOURCE 28 CELL: T-LYMPHOCYTE; SOURCE 29 CELLULAR_LOCATION: PLASMA MEMBRANE; SOURCE 30 GENE: V ALPHA 2.3 [AV2S1A2] - J ALPHA 24 - C ALPHA; SOURCE 31 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 32 EXPRESSION_SYSTEM_STRAIN: BL21 (DE3); SOURCE 33 EXPRESSION_SYSTEM_CELLULAR_LOCATION: REFOLDED FROM SOURCE 34 INCLUSION BODIES; SOURCE 35 EXPRESSION_SYSTEM_PLASMID: PLM1; SOURCE 36 MOL_ID: 5; SOURCE 37 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 38 ORGANISM_COMMON: HUMAN; SOURCE 39 CELL: T-LYMPHOCYTE; SOURCE 40 CELLULAR_LOCATION: PLASMA MEMBRANE; SOURCE 41 GENE: V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - C SOURCE 42 BETA 2; SOURCE 43 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 44 EXPRESSION_SYSTEM_STRAIN: BL21 (DE3); SOURCE 45 EXPRESSION_SYSTEM_CELLULAR_LOCATION: REFOLDED FROM SOURCE 46 INCLUSION BODIES; SOURCE 47 EXPRESSION_SYSTEM_PLASMID: PLM1 KEYWDS CLASS I MHC, T-CELL RECEPTOR, VIRAL PEPTIDE, KEYWDS 2 COMPLEX (MHC/VIRAL PEPTIDE/RECEPTOR EXPDTA X-RAY DIFFRACTION AUTHOR D.N.GARBOCZI,P.GHOSH,U.UTZ,Q.R.FAN,W.E.BIDDISON,D.C.WILEY REVDAT 1 17-SEP-97 1AO7 0 JRNL AUTH D.N.GARBOCZI,P.GHOSH,U.UTZ,Q.R.FAN,W.E.BIDDISON, JRNL AUTH 2 D.C.WILEY JRNL TITL STRUCTURE OF THE COMPLEX BETWEEN HUMAN T-CELL JRNL TITL 2 RECEPTOR, VIRAL PEPTIDE AND HLA-A2 JRNL REF NATURE V. 384 134 1996 JRNL REFN ASTM NATUAS UK ISSN 0028-0836 0006 REMARK 1 REMARK 1 REFERENCE 1 REMARK 1 AUTH D.N.GARBOCZI,U.UTZ,P.GHOSH,A.SETH,J.KIM, REMARK 1 AUTH 2 E.A.VANTIENHOVEN,W.E.BIDDISON,D.C.WILEY REMARK 1 TITL ASSEMBLY, SPECIFIC BINDING, AND CRYSTALLIZATION OF REMARK 1 TITL 2 A HUMAN TCR-ALPHABETA WITH AN ANTIGENIC TAX PEPTIDE REMARK 1 TITL 3 FROM HUMAN T LYMPHOTROPIC VIRUS TYPE 1 AND THE REMARK 1 TITL 4 CLASS I MHC MOLECULE HLA-A2 REMARK 1 REF J.IMMUNOL. V. 157 5403 1996 REMARK 1 REFN ASTM JOIMA3 US ISSN 0022-1767 0952 REMARK 2 REMARK 2 RESOLUTION. 2.6 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : X-PLOR 3.1 REMARK 3 AUTHORS : BRUNGER REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.6 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 6.0 REMARK 3 DATA CUTOFF (SIGMA(F)) : 0. REMARK 3 DATA CUTOFF HIGH (ABS(F)) : 1000000000. REMARK 3 DATA CUTOFF LOW (ABS(F)) : 0.0 REMARK 3 COMPLETENESS (WORKING+TEST) (%) : 94.9 REMARK 3 NUMBER OF REFLECTIONS : 29279 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : SHELLS REMARK 3 R VALUE (WORKING SET) : 0.245 REMARK 3 FREE R VALUE : 0.320 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 10.3 REMARK 3 FREE R VALUE TEST SET COUNT : 3006 REMARK 3 ESTIMATED ERROR OF FREE R VALUE : 0.006 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 8 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 2.60 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 2.71 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 83.7 REMARK 3 REFLECTIONS IN BIN (WORKING SET) : 2878 REMARK 3 BIN R VALUE (WORKING SET) : 0.359 REMARK 3 BIN FREE R VALUE : 0.416 REMARK 3 BIN FREE R VALUE TEST SET SIZE (%) : 9.1 REMARK 3 BIN FREE R VALUE TEST SET COUNT : 289 REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE : 0.024 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 5673 REMARK 3 NUCLEIC ACID ATOMS : 0 REMARK 3 HETEROGEN ATOMS : 6 REMARK 3 SOLVENT ATOMS : 37 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : 48.5 REMARK 3 MEAN B VALUE (OVERALL, A**2) : 42.4 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : -6. REMARK 3 B22 (A**2) : 6. REMARK 3 B33 (A**2) : 6. REMARK 3 B12 (A**2) : 0. REMARK 3 B13 (A**2) : 0. REMARK 3 B23 (A**2) : 0. REMARK 3 ........................................................ REMARK 410 REMARK 410 IMGT/3Dstructure-DB annotations REMARK 410 (http://www.imgt.org) REMARK 410 REMARK 410 ligand(s) REMARK 410 Ethyl Mercury Ion REMARK 410 IMGT receptor type REMARK 410 REMARK 410 IMGT receptor description REMARK 410 Ion REMARK 410 Species REMARK 410 Chain ID REMARK 410 1ao7_2 REMARK 410 REMARK 410 IMGT protein name REMARK 410 HLA-A*0201 REMARK 410 IMGT receptor type REMARK 410 MHC REMARK 410 IMGT receptor description REMARK 410 MHC-I-ALPHA_B2M REMARK 410 Species REMARK 410 Homo sapiens (Human) REMARK 410 Chain ID REMARK 410 1ao7_A,1ao7_B REMARK 410 REMARK 410 IMGT protein name REMARK 410 A6 REMARK 410 IMGT receptor type REMARK 410 TR REMARK 410 IMGT receptor description REMARK 410 TR-ALPHA_BETA-1 REMARK 410 Species REMARK 410 Homo sapiens (Human) REMARK 410 Chain ID REMARK 410 1ao7_D,1ao7_E REMARK 410 REMARK 410 ligand(s) REMARK 410 Ethyl Mercury Ion REMARK 410 IMGT receptor type REMARK 410 REMARK 410 IMGT receptor description REMARK 410 Ion REMARK 410 Species REMARK 410 Chain ID REMARK 410 1ao7_1 REMARK 410 REMARK 410 ligand(s) REMARK 410 Tax peptide 11-19 (Q82235) REMARK 410 IMGT receptor type REMARK 410 REMARK 410 IMGT receptor description REMARK 410 Peptide REMARK 410 Species REMARK 410 Human T lymphotropic virus type 1 REMARK 410 Chain ID REMARK 410 1ao7_C REMARK 410 REMARK 410 REMARK 410 Chain ID 1ao7_A (1AO7A) REMARK 410 IMGT chain description I-ALPHA REMARK 410 Chain amino acid sequence REMARK 410 [ G-DOMAIN REMARK 410 GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRK REMARK 410 ][ REMARK 410 VKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRS REMARK 410 G-DOMAIN ][ REMARK 410 WTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHE REMARK 410 C-LIKE-DOMAIN REMARK 410 ATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHE REMARK 410 ] REMARK 410 GLPKPLTLRWE REMARK 410 G-DOMAIN IMGT domain description G-ALPHA1 REMARK 410 G-DOMAIN IMGT gene and allele HLA-A*0201 REMARK 410 G-DOMAIN ..........GSHSMRY.FFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAA REMARK 410 G-DOMAIN SQRMEPRA.......PWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYN REMARK 410 G-DOMAIN QSEA REMARK 410 G-DOMAIN IMGT domain description G-ALPHA2 REMARK 410 G-DOMAIN IMGT gene and allele HLA-A*0201 REMARK 410 G-DOMAIN ..........GSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKED..L REMARK 410 G-DOMAIN RSWTAAD.......MAAQTTKHKWEAA.HVAEQLRAYLEGTCVEWLRRYLEN REMARK 410 G-DOMAIN GKETLQRT REMARK 410 C-LIKE-DOMAIN IMGT domain description C-LIKE REMARK 410 C-LIKE-DOMAIN IMGT gene and allele HLA-A*0201 REMARK 410 C-LIKE-DOMAIN Sheet composition [A B D E] [C F G] REMARK 410 C-LIKE-DOMAIN .......DAPKTHMTHHAVSD......HEATLRCWALSFYP..AEITLTWQR REMARK 410 C-LIKE-DOMAIN DGEDQTQ..DTELVETRPAGD......GTFQKWAAVVVPSG.....QEQRYT REMARK 410 C-LIKE-DOMAIN CHVQHEG..LPKPLTLRW REMARK 410 REMARK 410 Chain ID 1ao7_B (1AO7B) REMARK 410 IMGT chain description B2M REMARK 410 Chain amino acid sequence REMARK 410 [ C-LIKE-DOMAIN REMARK 410 MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLL REMARK 410 ] REMARK 410 YCTEFTPTEKDEYACRVNHVTLSQPCIVKWDRDM REMARK 410 C-LIKE-DOMAIN IMGT domain description C-LIKE REMARK 410 C-LIKE-DOMAIN IMGT gene and allele B2M REMARK 410 C-LIKE-DOMAIN Sheet composition [A B D E] [C F G] REMARK 410 C-LIKE-DOMAIN .....IQRTPKIQVYSRHPAEN....GKSNFLNCYVSGFHP..SDIEVDLLK REMARK 410 C-LIKE-DOMAIN NGERIE...KVEHSDLSFSKD......WSFYLLYCTEFTPTE.....KDEYA REMARK 410 C-LIKE-DOMAIN CRVNHVT..LSQPCIVKWDRDM REMARK 410 REMARK 410 Chain ID 1ao7_D (1AO7D) REMARK 410 IMGT chain description TR-ALPHA REMARK 410 Chain amino acid sequence REMARK 410 [ V-REGION REMARK 410 KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNK REMARK 410 ][ J-REGION ] [ REMARK 410 ASQYVSLLIRDSQPSDSATYLCAVTTDSWGKLQFGAGTQVVVTPDIQNPDPAVYQLRDSKSSDKSV REMARK 410 C-REGION REMARK 410 CLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFF REMARK 410 ] REMARK 410 PSPESS REMARK 410 V-DOMAIN IMGT domain description V-ALPHA REMARK 410 V-DOMAIN IMGT gene and allele TRAV12-2*02 REMARK 410 V-DOMAIN IMGT gene and allele TRAJ24*02 REMARK 410 V-DOMAIN CDR-IMGT length [6.6.11] REMARK 410 V-DOMAIN Sheet composition [A' B C" D E] [A" C C' F G] REMARK 410 V-DOMAIN [ CDR1 ] REMARK 410 V-DOMAIN .KEVEQNSGPLSVPEGAIASLNCTYSDRG......SQSFFWYRQYSGKSPEL REMARK 410 V-DOMAIN [ CDR2 ] REMARK 410 V-DOMAIN IMSIYS....NGDKED.....GRFTAQLNKASQYVSLLIRDSQPSDSATYLC REMARK 410 V-DOMAIN [ CDR3 ] REMARK 410 V-DOMAIN AVTTDS..WGKLQFGAGTQVVVTP REMARK 410 C-DOMAIN IMGT domain description C-ALPHA REMARK 410 C-DOMAIN IMGT gene and allele TRAC*01 REMARK 410 C-DOMAIN Sheet composition [A' B E] [C F] REMARK 410 C-DOMAIN ....IQNPDPAVYQLRDSK........SSDKSVCLFTDFDS...QTNVSQSK REMARK 410 C-DOMAIN DS.......DVYITDKTVLDMRSM.DFKSNSAVAWSNKS..........DFA REMARK 410 C-DOMAIN CANAFNN..SIIPEDTFFPSP REMARK 410 REMARK 410 Chain ID 1ao7_E (1AO7E) REMARK 410 IMGT chain description TR-BETA-1 REMARK 410 Chain amino acid sequence REMARK 410 [ V-REGION REMARK 410 NAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVGAGITDQGEVPNGYNV REMARK 410 ]N-AND-D-R[ J-REGION ][ REMARK 410 SRSTTEDFPLRLLSAAPSQTSVYFCASRPGLAGGRPEQYFGPGTRLTVTEDLKNVFPPEVAVFEPS REMARK 410 C-REGION REMARK 410 EAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYALSSRLRVS REMARK 410 ] REMARK 410 ATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD REMARK 410 V-DOMAIN IMGT domain description V-BETA REMARK 410 V-DOMAIN IMGT gene and allele TRBV6-5*01 REMARK 410 V-DOMAIN IMGT gene and allele TRBJ2-7*01 REMARK 410 V-DOMAIN CDR-IMGT length [5.6.14] REMARK 410 V-DOMAIN Sheet composition [A' B D E] [A" C C' C" F G] REMARK 410 V-DOMAIN [ CDR1 ] REMARK 410 V-DOMAIN NAGVTQTPKFQVLKTGQSMTLQCAQDMNH.......EYMSWYRQDPGMGLRL REMARK 410 V-DOMAIN [ CDR2 ] REMARK 410 V-DOMAIN IHYSVG....AGITDQGEVP.NGYNVSRS.TTEDFPLRLLSAAPSQTSVYFC REMARK 410 V-DOMAIN [ CDR3 ] REMARK 410 V-DOMAIN ASRPGLAGGRPEQYFGPGTRLTVT REMARK 410 C-DOMAIN IMGT domain description C-BETA-1 REMARK 410 C-DOMAIN IMGT gene and allele TRBC2*01, TRBC2*02 REMARK 410 C-DOMAIN Sheet composition [A B D E] [C F G] REMARK 410 C-DOMAIN .EDLKNVFPPEVAVFEPSEAEISH..TQKATLVCLATGFYP..DHVELSWWV REMARK 410 C-DOMAIN NGKEVHS..GVSTDPQPLKEQPAL.NDSRYALSSRLRVSATFWQ.NPRNHFR REMARK 410 C-DOMAIN CQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRA REMARK 600 REMARK 600 HETEROGEN REMARK 600 EMC B 100 IS COVALENTLY LINKED TO B67C; EMC B 101 REMARK 600 IS COVALENTLY LINKED TO B91C. DBREF 1AO7 A 1 274 PDB 1AO7 1AO7 1 274 DBREF 1AO7 B 0 99 PDB 1AO7 1AO7 0 99 DBREF 1AO7 C 1 9 PDB 1AO7 1AO7 1 9 DBREF 1AO7 D 1 121 PDB 1AO7 1AO7 1 121 DBREF 1AO7 E 3 246 PDB 1AO7 1AO7 3 246 SEQRES 1 A 275 GLY SER HIS SER MET ARG TYR PHE PHE THR SER VAL SER SEQRES 2 A 275 ARG PRO GLY ARG GLY GLU PRO ARG PHE ILE ALA VAL GLY SEQRES 3 A 275 TYR VAL ASP ASP THR GLN PHE VAL ARG PHE ASP SER ASP SEQRES 4 A 275 ALA ALA SER GLN ARG MET GLU PRO ARG ALA PRO TRP ILE SEQRES 5 A 275 GLU GLN GLU GLY PRO GLU TYR TRP ASP GLY GLU THR ARG SEQRES 6 A 275 LYS VAL LYS ALA HIS SER GLN THR HIS ARG VAL ASP LEU SEQRES 7 A 275 GLY THR LEU ARG GLY TYR TYR ASN GLN SER GLU ALA GLY SEQRES 8 A 275 SER HIS THR VAL GLN ARG MET TYR GLY CYS ASP VAL GLY SEQRES 9 A 275 SER ASP TRP ARG PHE LEU ARG GLY TYR HIS GLN TYR ALA SEQRES 10 A 275 TYR ASP GLY LYS ASP TYR ILE ALA LEU LYS GLU ASP LEU SEQRES 11 A 275 ARG SER TRP THR ALA ALA ASP MET ALA ALA GLN THR THR SEQRES 12 A 275 LYS HIS LYS TRP GLU ALA ALA HIS VAL ALA GLU GLN LEU SEQRES 13 A 275 ARG ALA TYR LEU GLU GLY THR CYS VAL GLU TRP LEU ARG SEQRES 14 A 275 ARG TYR LEU GLU ASN GLY LYS GLU THR LEU GLN ARG THR SEQRES 15 A 275 ASP ALA PRO LYS THR HIS MET THR HIS HIS ALA VAL SER SEQRES 16 A 275 ASP HIS GLU ALA THR LEU ARG CYS TRP ALA LEU SER PHE SEQRES 17 A 275 TYR PRO ALA GLU ILE THR LEU THR TRP GLN ARG ASP GLY SEQRES 18 A 275 GLU ASP GLN THR GLN ASP THR GLU LEU VAL GLU THR ARG SEQRES 19 A 275 PRO ALA GLY ASP GLY THR PHE GLN LYS TRP ALA ALA VAL SEQRES 20 A 275 VAL VAL PRO SER GLY GLN GLU GLN ARG TYR THR CYS HIS SEQRES 21 A 275 VAL GLN HIS GLU GLY LEU PRO LYS PRO LEU THR LEU ARG SEQRES 22 A 275 TRP GLU SEQRES 1 B 100 MET ILE GLN ARG THR PRO LYS ILE GLN VAL TYR SER ARG SEQRES 2 B 100 HIS PRO ALA GLU ASN GLY LYS SER ASN PHE LEU ASN CYS SEQRES 3 B 100 TYR VAL SER GLY PHE HIS PRO SER ASP ILE GLU VAL ASP SEQRES 4 B 100 LEU LEU LYS ASN GLY GLU ARG ILE GLU LYS VAL GLU HIS SEQRES 5 B 100 SER ASP LEU SER PHE SER LYS ASP TRP SER PHE TYR LEU SEQRES 6 B 100 LEU TYR CYS THR GLU PHE THR PRO THR GLU LYS ASP GLU SEQRES 7 B 100 TYR ALA CYS ARG VAL ASN HIS VAL THR LEU SER GLN PRO SEQRES 8 B 100 CYS ILE VAL LYS TRP ASP ARG ASP MET SEQRES 1 C 9 LEU LEU PHE GLY TYR PRO VAL TYR VAL SEQRES 1 D 204 LYS GLU VAL GLU GLN ASN SER GLY PRO LEU SER VAL PRO SEQRES 2 D 204 GLU GLY ALA ILE ALA SER LEU ASN CYS THR TYR SER ASP SEQRES 3 D 204 ARG GLY SER GLN SER PHE PHE TRP TYR ARG GLN TYR SER SEQRES 4 D 204 GLY LYS SER PRO GLU LEU ILE MET SER ILE TYR SER ASN SEQRES 5 D 204 GLY ASP LYS GLU ASP GLY ARG PHE THR ALA GLN LEU ASN SEQRES 6 D 204 LYS ALA SER GLN TYR VAL SER LEU LEU ILE ARG ASP SER SEQRES 7 D 204 GLN PRO SER ASP SER ALA THR TYR LEU CYS ALA VAL THR SEQRES 8 D 204 THR ASP SER TRP GLY LYS LEU GLN PHE GLY ALA GLY THR SEQRES 9 D 204 GLN VAL VAL VAL THR PRO ASP ILE GLN ASN PRO ASP PRO SEQRES 10 D 204 ALA VAL TYR GLN LEU ARG ASP SER LYS SER SER ASP LYS SEQRES 11 D 204 SER VAL CYS LEU PHE THR ASP PHE ASP SER GLN THR ASN SEQRES 12 D 204 VAL SER GLN SER LYS ASP SER ASP VAL TYR ILE THR ASP SEQRES 13 D 204 LYS THR VAL LEU ASP MET ARG SER MET ASP PHE LYS SER SEQRES 14 D 204 ASN SER ALA VAL ALA TRP SER ASN LYS SER ASP PHE ALA SEQRES 15 D 204 CYS ALA ASN ALA PHE ASN ASN SER ILE ILE PRO GLU ASP SEQRES 16 D 204 THR PHE PHE PRO SER PRO GLU SER SER SEQRES 1 E 245 ASN ALA GLY VAL THR GLN THR PRO LYS PHE GLN VAL LEU SEQRES 2 E 245 LYS THR GLY GLN SER MET THR LEU GLN CYS ALA GLN ASP SEQRES 3 E 245 MET ASN HIS GLU TYR MET SER TRP TYR ARG GLN ASP PRO SEQRES 4 E 245 GLY MET GLY LEU ARG LEU ILE HIS TYR SER VAL GLY ALA SEQRES 5 E 245 GLY ILE THR ASP GLN GLY GLU VAL PRO ASN GLY TYR ASN SEQRES 6 E 245 VAL SER ARG SER THR THR GLU ASP PHE PRO LEU ARG LEU SEQRES 7 E 245 LEU SER ALA ALA PRO SER GLN THR SER VAL TYR PHE CYS SEQRES 8 E 245 ALA SER ARG PRO GLY LEU ALA GLY GLY ARG PRO GLU GLN SEQRES 9 E 245 TYR PHE GLY PRO GLY THR ARG LEU THR VAL THR GLU ASP SEQRES 10 E 245 LEU LYS ASN VAL PHE PRO PRO GLU VAL ALA VAL PHE GLU SEQRES 11 E 245 PRO SER GLU ALA GLU ILE SER HIS THR GLN LYS ALA THR SEQRES 12 E 245 LEU VAL CYS LEU ALA THR GLY PHE TYR PRO ASP HIS VAL SEQRES 13 E 245 GLU LEU SER TRP TRP VAL ASN GLY LYS GLU VAL HIS SER SEQRES 14 E 245 GLY VAL SER THR ASP PRO GLN PRO LEU LYS GLU GLN PRO SEQRES 15 E 245 ALA LEU ASN ASP SER ARG TYR ALA LEU SER SER ARG LEU SEQRES 16 E 245 ARG VAL SER ALA THR PHE TRP GLN ASN PRO ARG ASN HIS SEQRES 17 E 245 PHE ARG CYS GLN VAL GLN PHE TYR GLY LEU SER GLU ASN SEQRES 18 E 245 ASP GLU TRP THR GLN ASP ARG ALA LYS PRO VAL THR GLN SEQRES 19 E 245 ILE VAL SER ALA GLU ALA TRP GLY ARG ALA ASP HET EMC 1 2 3 HET EMC 2 3 3 HETNAM EMC ETHYL MERCURY ION FORMUL 6 EMC 2(C2 H5 HG1 1+) FORMUL 7 HOH *37(H2 O1) HELIX 1 1 PRO A 50 GLU A 55 5 6 HELIX 2 2 PRO A 57 TYR A 84 1 28 HELIX 3 3 MET A 1050 ALA A 1061 1 12 HELIX 4 4 VAL A 1063 GLU A 1072 1 10 HELIX 5 5 THR A 1073 ASN A 1084 1 12 HELIX 6 6 LYS A 1086 LEU A 1089 1 4 HELIX 7 7 GLN A 2045C ASP A 2077 5 4 HELIX 8 8 GLN A 2098 ARG A 2101 5 4 HELIX 9 9 PRO D 96 ASP D 98 5 3 HELIX 10 10 PRO E 96 GLN E 98 5 3 HELIX 11 11 GLY E 109 ALA E 111 5 3 HELIX 12 12 ALA E 1093 TRP E 1096 1 4 SHEET 1 A 7 GLN A 32 ASP A 37 0 SHEET 2 A 7 ARG A 21 TYR A 27 -1 N GLY A 26 O PHE A 33 SHEET 3 A 7 HIS A 3 VAL A 12 -1 N VAL A 12 O ARG A 21 SHEET 4 A 7 THR A1004 VAL A1013 -1 N VAL A1013 O HIS A 3 SHEET 5 A 7 PHE A1019 TYR A1028 -1 N ALA A1027 O GLN A1006 SHEET 6 A 7 LYS A1031 LEU A1036 -1 N ILE A1034 O TYR A1026 SHEET 7 A 7 TRP A1045 ALA A1047 -1 N THR A1046 O ALA A1035 SHEET 1 B 3 LYS A2085 VAL A2091 0 SHEET 2 B 3 GLU A2018 ALA A2025 -1 N ALA A2025 O LYS A2085 SHEET 3 B 3 HIS A2005 SER A2012 -1 N SER A2012 O GLU A2018 SHEET 1 C 3 THR A2038 GLN A2042 0 SHEET 2 C 3 THR A2103 GLN A2107 -1 N GLN A2107 O THR A2038 SHEET 3 C 3 LEU A2117 ARG A2120 -1 N LEU A2119 O CYS A2104 SHEET 1 D 3 LYS B1003 SER B1008 0 SHEET 2 D 3 SER B1018 PHE B1028 -1 N SER B1026 O LYS B1003 SHEET 3 D 3 PHE B1085B THR B1092 -1 N PHE B1091 O ASN B1019 SHEET 1 E 3 GLU B1038 LYS B1043 0 SHEET 2 E 3 TYR B1102 ASN B1107 -1 N ASN B1107 O GLU B1038 SHEET 3 E 3 CYS B1117 LYS B1120 -1 N VAL B1119 O CYS B1104 SHEET 1 F 4 VAL D 4 GLN D 6 0 SHEET 2 F 4 ALA D 19 TYR D 25 -1 N THR D 24 O GLU D 5 SHEET 3 F 4 TYR D 86 ILE D 91 -1 N ILE D 91 O ALA D 19 SHEET 4 F 4 PHE D 76 ASN D 81 -1 N ASN D 81 O TYR D 86 SHEET 1 G 5 LEU D 11 PRO D 14 0 SHEET 2 G 5 THR D 122 THR D 127 1 N VAL D 125 O LEU D 11 SHEET 3 G 5 ALA D 100 THR D 107 -1 N TYR D 102 O THR D 122 SHEET 4 G 5 SER D 38 GLN D 44 -1 N GLN D 44 O THR D 101 SHEET 5 G 5 GLU D 51 ILE D 56 -1 N ILE D 56 O PHE D 39 SHEET 1 H 2 VAL E 4 THR E 7 0 SHEET 2 H 2 GLN E 22 GLN E 25 -1 N ALA E 24 O THR E 5 SHEET 1 I 5 PHE E 10 LYS E 14 0 SHEET 2 I 5 THR E 122 THR E 127 1 N ARG E 123 O GLN E 11 SHEET 3 I 5 SER E 100 ARG E 107 -1 N TYR E 102 O THR E 122 SHEET 4 I 5 TYR E 38 ASP E 45 -1 N GLN E 44 O VAL E 101 SHEET 5 I 5 GLY E 49 SER E 56 -1 N SER E 56 O MET E 39 SHEET 1 J 3 MET E 19 LEU E 21 0 SHEET 2 J 3 LEU E 89 LEU E 91 -1 N LEU E 91 O MET E 19 SHEET 3 J 3 TYR E 76 VAL E 78 -1 N ASN E 77 O ARG E 90 SHEET 1 K 3 VAL E1022 THR E1026 0 SHEET 2 K 3 ALA E1085A LEU E1089 -1 N SER E1087 O CYS E1023 SHEET 3 K 3 VAL E1078 THR E1080 -1 N SER E1079 O ARG E1088 SHEET 1 L 4 LYS E1045A VAL E1045C 0 SHEET 2 L 4 VAL E1037 VAL E1043 -1 N VAL E1043 O LYS E1045A SHEET 3 L 4 HIS E1101 PHE E1108 -1 N GLN E1107 O GLU E1038 SHEET 4 L 4 GLN E1115 TRP E1122 -1 N ALA E1121 O PHE E1102 LINK SG CYS B 67 HG EMC B 100 LINK SG CYS B 91 HG EMC B 101 CISPEP 1 TYR A 2029 PRO A 2030 0 -0.41 CISPEP 2 HIS B 1029 PRO B 1030 0 -1.78 CISPEP 3 THR E 7 PRO E 8 0 0.74 CISPEP 4 TYR E 1029 PRO E 1030 0 -1.68 CRYST1 229.300 49.500 96.000 90.00 89.60 90.00 C 1 2 1 4 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.004361 0.000000 -0.000030 0.00000 SCALE2 0.000000 0.020202 0.000000 0.00000 SCALE3 0.000000 0.000000 0.010417 0.00000 ATOM 1 N GLY A 1 85.564 -4.761 25.104 1.00 67.69 N ATOM 2 CA GLY A 1 85.170 -3.333 24.892 1.00 66.29 C ATOM 3 C GLY A 1 85.179 -2.949 23.426 1.00 61.56 C ATOM 4 O GLY A 1 85.802 -1.961 23.040 1.00 60.06 O ATOM 5 N SER A 2 84.482 -3.738 22.616 1.00 56.15 N ATOM 6 CA SER A 2 84.397 -3.509 21.179 1.00 48.85 C ATOM 7 C SER A 2 83.501 -2.310 20.849 1.00 44.01 C ATOM 8 O SER A 2 82.760 -1.827 21.703 1.00 44.66 O ATOM 9 CB SER A 2 83.860 -4.773 20.507 1.00 45.46 C ATOM 10 OG SER A 2 84.540 -5.918 21.000 1.00 47.65 O ATOM 11 N HIS A 3 83.637 -1.782 19.636 1.00 34.75 N ATOM 12 CA HIS A 3 82.826 -0.650 19.176 1.00 30.98 C ATOM 13 C HIS A 3 82.531 -0.852 17.699 1.00 28.76 C ATOM 14 O HIS A 3 83.043 -1.801 17.097 1.00 33.28 O ATOM 15 CB HIS A 3 83.560 0.678 19.386 1.00 31.92 C ATOM 16 CG HIS A 3 83.888 0.970 20.817 1.00 31.60 C ATOM 17 ND1 HIS A 3 83.128 1.804 21.604 1.00 32.24 N ATOM 18 CD2 HIS A 3 84.892 0.518 21.609 1.00 33.94 C ATOM 19 CE1 HIS A 3 83.640 1.853 22.821 1.00 30.53 C ATOM 20 NE2 HIS A 3 84.714 1.079 22.849 1.00 34.02 N ATOM 21 N SER A 4 81.744 0.045 17.107 1.00 25.67 N ATOM 22 CA SER A 4 81.400 -0.085 15.698 1.00 21.84 C ATOM 23 C SER A 4 80.787 1.171 15.142 1.00 22.02 C ATOM 24 O SER A 4 80.148 1.910 15.866 1.00 17.37 O ATOM 25 CB SER A 4 80.384 -1.214 15.519 1.00 24.16 C ATOM 26 OG SER A 4 79.070 -0.736 15.716 1.00 34.10 O ATOM 27 N MET A 5 80.981 1.435 13.855 1.00 19.64 N ATOM 28 CA MET A 5 80.343 2.594 13.257 1.00 17.86 C ATOM 29 C MET A 5 79.512 2.056 12.107 1.00 20.27 C ATOM 30 O MET A 5 79.964 1.166 11.380 1.00 20.81 O ATOM 31 CB MET A 5 81.353 3.593 12.732 1.00 25.86 C ATOM 32 CG MET A 5 80.699 4.734 11.980 1.00 27.77 C ATOM 33 SD MET A 5 81.824 6.082 11.753 1.00 32.69 S ATOM 34 CE MET A 5 82.992 5.335 10.638 1.00 37.96 C ATOM 35 N ARG A 6 78.289 2.563 11.963 1.00 19.24 N ATOM 36 CA ARG A 6 77.394 2.114 10.907 1.00 15.40 C ATOM 37 C ARG A 6 76.604 3.253 10.317 1.00 20.14 C ATOM 38 O ARG A 6 76.228 4.190 11.024 1.00 19.90 O ATOM 39 CB ARG A 6 76.343 1.146 11.446 1.00 15.18 C ATOM 40 CG ARG A 6 76.820 0.013 12.283 1.00 18.52 C ATOM 41 CD ARG A 6 76.596 -1.268 11.551 1.00 26.30 C ATOM 42 NE ARG A 6 77.876 -1.878 11.243 1.00 36.20 N ATOM 43 CZ ARG A 6 78.525 -2.677 12.074 1.00 47.34 C ATOM 44 NH1 ARG A 6 78.005 -2.975 13.259 1.00 60.82 N ATOM 45 NH2 ARG A 6 79.730 -3.110 11.754 1.00 46.86 N ATOM 46 N TYR A 7 76.303 3.128 9.027 1.00 21.15 N ATOM 47 CA TYR A 7 75.473 4.092 8.322 1.00 17.14 C ATOM 48 C TYR A 7 74.350 3.276 7.690 1.00 18.28 C ATOM 49 O TYR A 7 74.601 2.172 7.175 1.00 23.21 O ATOM 50 CB TYR A 7 76.264 4.855 7.252 1.00 14.22 C ATOM 51 CG TYR A 7 77.110 5.986 7.792 1.00 12.58 C ATOM 52 CD1 TYR A 7 76.573 7.262 7.988 1.00 14.65 C ATOM 53 CD2 TYR A 7 78.450 5.778 8.114 1.00 18.03 C ATOM 54 CE1 TYR A 7 77.361 8.304 8.495 1.00 10.18 C ATOM 55 CE2 TYR A 7 79.239 6.800 8.612 1.00 14.60 C ATOM 56 CZ TYR A 7 78.701 8.061 8.806 1.00 18.98 C ATOM 57 OH TYR A 7 79.526 9.053 9.308 1.00 18.55 O ATOM 58 N PHE A 8 73.122 3.783 7.800 1.00 12.38 N ATOM 59 CA PHE A 8 71.943 3.129 7.257 1.00 14.86 C ATOM 60 C PHE A 8 71.316 4.107 6.274 1.00 19.07 C ATOM 61 O PHE A 8 71.231 5.297 6.576 1.00 24.70 O ATOM 62 CB PHE A 8 70.946 2.832 8.381 1.00 22.85 C ATOM 63 CG PHE A 8 71.504 1.956 9.471 1.00 15.26 C ATOM 64 CD1 PHE A 8 72.219 2.508 10.532 1.00 14.84 C ATOM 65 CD2 PHE A 8 71.339 0.577 9.419 1.00 16.04 C ATOM 66 CE1 PHE A 8 72.775 1.698 11.513 1.00 12.74 C ATOM 67 CE2 PHE A 8 71.888 -0.244 10.392 1.00 9.97 C .............................................................................. TER 5680 ASP E2001 HETATM 5681 O HOH 1 51.923 15.363 15.644 1.00 20.23 O HETATM 5682 O HOH 2 59.138 -2.265 -0.480 1.00 13.92 O HETATM 5683 O HOH 3 56.727 -11.401 3.298 1.00 22.48 O HETATM 5684 O HOH 4 61.803 -0.255 -7.679 1.00 49.05 O HETATM 5685 O HOH 5 107.504 24.498 -28.709 1.00 46.98 O HETATM 5686 O HOH 6 73.531 22.885 -14.952 1.00 21.92 O HETATM 5687 O HOH 7 64.065 4.928 14.323 1.00 9.12 O HETATM 5688 O HOH 8 78.333 11.356 -11.531 1.00 19.64 O HETATM 5689 O HOH 9 51.004 1.755 5.219 1.00 60.87 O HETATM 5690 O HOH 10 54.868 11.499 -10.257 1.00 46.38 O HETATM 5691 O HOH 11 90.901 35.660 -18.096 1.00 33.35 O HETATM 5692 O HOH 12 43.183 7.204 24.940 1.00 31.06 O HETATM 5693 O HOH 13 77.938 1.439 -4.760 1.00 21.37 O HETATM 5694 O HOH 14 108.869 21.911 -30.049 1.00 27.99 O HETATM 5695 O HOH 15 56.061 9.665 36.547 1.00 23.19 O HETATM 5696 O HOH 16 59.657 8.317 8.969 1.00 33.35 O HETATM 5697 O HOH 17 93.929 -5.069 0.403 1.00 48.58 O HETATM 5698 O HOH 18 44.816 16.949 15.540 1.00 44.78 O HETATM 5699 O HOH 19 106.776 6.196 -16.197 1.00 41.45 O HETATM 5700 O HOH 20 79.148 11.572 8.841 1.00 20.50 O HETATM 5701 O HOH 21 100.565 16.907 -24.523 1.00 28.33 O HETATM 5702 O HOH 22 103.993 14.956 -19.267 1.00 20.09 O HETATM 5703 O HOH 23 55.914 13.804 14.944 1.00 22.25 O HETATM 5704 O HOH 24 46.447 4.582 29.936 1.00 19.69 O HETATM 5705 O HOH 25 56.724 -0.881 -0.569 1.00 24.47 O HETATM 5706 O HOH 26 77.767 17.429 -24.413 1.00 41.97 O HETATM 5707 O HOH 27 66.754 8.942 -3.649 1.00 17.04 O HETATM 5708 O HOH 28 61.162 -7.500 -5.725 1.00 25.24 O HETATM 5709 O HOH 29 74.260 1.651 -5.347 1.00 31.09 O HETATM 5710 O HOH 30 83.454 18.762 -27.321 1.00 46.11 O HETATM 5711 O HOH 31 47.536 17.935 21.631 1.00 28.22 O HETATM 5712 O HOH 32 63.404 13.197 -11.892 1.00 31.94 O HETATM 5713 O HOH 33 52.208 9.264 12.276 1.00 23.21 O HETATM 5714 O HOH 34 62.688 -7.466 5.887 1.00 34.67 O HETATM 5715 O HOH 35 83.770 14.966 16.910 1.00 37.10 O HETATM 5716 O HOH 36 69.312 -6.130 23.486 1.00 39.61 O HETATM 5717 O HOH 37 43.462 16.541 19.252 1.00 36.56 O CONECT 819 818 1335 CONECT 1335 819 1334 CONECT 1659 1658 2109 CONECT 2109 1659 2108 CONECT 2450 2449 2907 CONECT 2907 2450 2906 CONECT 3069 3070 CONECT 3070 3069 3071 CONECT 3071 3070 CONECT 3072 3073 CONECT 3073 3072 3074 CONECT 3074 3073 CONECT 3307 3306 3839 CONECT 3839 3307 3838 CONECT 4197 4196 4732 CONECT 4732 4197 4731 CONECT 5041 5040 5492 CONECT 5492 5041 5491 MASTER 216 0 2 12 45 0 0 6 5712 5 18 66 END
REMARK 410 REMARK 410 IMGT/2Dstructure-DB annotations REMARK 410 (http://www.imgt.org) REMARK 410 REMARK 410 INN number REMARK 410 7637 REMARK 410 Common name REMARK 410 4D5-humanized variant 8, Herceptin REMARK 410 INN name REMARK 410 trastuzumab REMARK 410 IMGT receptor type REMARK 410 IG REMARK 410 IMGT receptor description REMARK 410 IG-GAMMA-1_KAPPA REMARK 410 Species REMARK 410 Humanized REMARK 410 Chain ID REMARK 410 7637_H,7637_L REMARK 410 REMARK 410 REMARK 410 Chain ID 7637_H (7637H) REMARK 410 IMGT chain description H-GAMMA-1 REMARK 410 Chain amino acid sequence REMARK 410 [ V-REGION REMARK 410 EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKG REMARK 410 ]N-AND[ J-REGION ][ REMARK 410 RFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLA REMARK 410 CH1 REMARK 410 PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGT REMARK 410 ][HINGE-REGION ][ REMARK 410 QTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTC REMARK 410 CH2 REMARK 410 VVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKA REMARK 410 ][ C REMARK 410 LPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKT REMARK 410 H3 ] REMARK 410 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK REMARK 410 V-DOMAIN IMGT domain description VH REMARK 410 V-DOMAIN IMGT gene and allele IGHV3-66*01, IGHV3-66*02, REMARK 410 V-DOMAIN IMGT gene and allele IGHV3-66*04 REMARK 410 V-DOMAIN IMGT gene and allele IGHJ6*01, IGHJ6*02 REMARK 410 V-DOMAIN CDR-IMGT length [8.8.13] REMARK 410 V-DOMAIN [ CDR1 ] REMARK 410 V-DOMAIN EVQLVESGG.GLVQPGGSLRLSCAASGFNI....KDTYIHWVRQAPGKGLEW REMARK 410 V-DOMAIN [ CDR2 ] REMARK 410 V-DOMAIN VARIYPT..NGYTRYADSVK.GRFTISADTSKNTAYLQMNSLRAEDTAVYYC REMARK 410 V-DOMAIN [ CDR3 ] REMARK 410 V-DOMAIN SRWGGDGFYAMDYWGQGTLVTVSS REMARK 410 C-DOMAIN IMGT domain description CH1 REMARK 410 C-DOMAIN IMGT gene and allele IGHG1*01, IGHG1*02, REMARK 410 C-DOMAIN IMGT gene and allele IGHG1*03 REMARK 410 C-DOMAIN ....ASTKGPSVFPLAPSSKSTS...GGTAALGCLVKDYFP..EPVTVSWNS REMARK 410 C-DOMAIN GALTS....GVHTFPAVLQSS......GLYSLSSVVTVPSSSL...GTQTYI REMARK 410 C-DOMAIN CNVNHKP..SNTKVDKKV REMARK 410 C-DOMAIN IMGT domain description CH2 REMARK 410 C-DOMAIN IMGT gene and allele IGHG1*01, IGHG1*02, REMARK 410 C-DOMAIN IMGT gene and allele IGHG1*03 REMARK 410 C-DOMAIN ..APELLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVVDVSHEDPEVKFNWYV REMARK 410 C-DOMAIN DGVEVH...NAKTKPREEQYN......STYRVVSVLTVLHQDW..LNGKEYK REMARK 410 C-DOMAIN CKVSNKA..LPAPIEKTISKAK REMARK 410 C-DOMAIN IMGT domain description CH3 REMARK 410 C-DOMAIN IMGT gene and allele IGHG1*01, IGHG1*02, REMARK 410 C-DOMAIN IMGT gene and allele IGHG1*03 REMARK 410 C-DOMAIN ....GQPREPQVYTLPPSREEMT...KNQVSLTCLVKGFYP..SDIAVEWES REMARK 410 C-DOMAIN NGQPEN...NYKTTPPVLDSD......GSFFLYSKLTVDKSRW..QQGNVFS REMARK 410 C-DOMAIN CSVMHEA.LHNHYTQKSLSLSP...GK REMARK 410 REMARK 410 Chain ID 7637_L (7637L) REMARK 410 IMGT chain description L-KAPPA REMARK 410 Chain amino acid sequence REMARK 410 [ V-REGION REMARK 410 DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSR REMARK 410 ] [J-REGION ][ REMARK 410 SGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASV REMARK 410 C-REGION REMARK 410 VCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH REMARK 410 ] REMARK 410 QGLSSPVTKSFNRGEC REMARK 410 V-DOMAIN IMGT domain description V-KAPPA REMARK 410 V-DOMAIN IMGT gene and allele IGKV1-39*01, IGKV1D-39*01 REMARK 410 V-DOMAIN IMGT gene and allele IGKJ1*01 REMARK 410 V-DOMAIN CDR-IMGT length [6.3.9] REMARK 410 V-DOMAIN [ CDR1 ] REMARK 410 V-DOMAIN DIQMTQSPSSLSASVGDRVTITCRASQDV......NTAVAWYQQKPGKAPKL REMARK 410 V-DOMAIN [ CDR2 ] REMARK 410 V-DOMAIN LIYSA.......SFLYSGVP.SRFSGSR..SGTDFTLTISSLQPEDFATYYC REMARK 410 V-DOMAIN [ CDR3 ] REMARK 410 V-DOMAIN QQHYT....TPPTFGQGTKVEIK REMARK 410 C-DOMAIN IMGT domain description C-KAPPA REMARK 410 C-DOMAIN IMGT gene and allele IGKC*01 REMARK 410 C-DOMAIN ....RTVAAPSVFIFPPSDEQLK...SGTASVVCLLNNFYP..REAKVQWKV REMARK 410 C-DOMAIN DNALQSG..NSQESVTEQDSKD.....STYSLSSTLTLSKADY..EKHKVYA REMARK 410 C-DOMAIN CEVTHQG..LSSPVTKSFNRGEC REMARK 410 REMARK 410 English definition REMARK 410 immunoglobulin G1 (human-mouse monoclonal rhuMab HER2 γ1-chain anti-human p185c-erbB2 receptor), disulfide with human-mouee monoclonal rhuMab HER2 light chain, dimer immunomodulator REMARK 410 REMARK 410 French definition REMARK 410 immunoglobuline G1 (chaîne γ1 de l'anticorps monoclonal de souris humanisé rhuMab HER2 dirigé contre Ie récepteur humain p185c-erbB2), dimère du disulfure avec la chaîne légere de l'anticorps monoclonal de souris humanisé rhuMab HER2 immunomodulateur REMARK 410 REMARK 410 Spanish definition REMARK 410 inmunoglobulina G1 (cadena γ1 del anticuerpo monoclonal humanizado de ratón rhuMab HER2 dirigido contra el receptor humano p185c-erbB2), dímero del disulfuro con la cadena ligera del anticuerpo monoclonal humanizado de ratón rhuMab HER2 inmunomodulador REMARK 410 REMARK 410 Proposed list REMARK 410 L78 (1997) REMARK 410 REMARK 410 Recommended list REMARK 410 R40 (1998) REMARK 410 REMARK 410 Cas number REMARK 410 180288-69-1_H 180288-69-1_L REMARK 410 REMARK 410 Disulfide bridges REMARK 410 REMARK 410 Associated PDB REMARK 410 1n8z REMARK 410
REMARK 410 REMARK 410 IMGT/2Dstructure-DB annotations REMARK 410 (http://www.imgt.org) REMARK 410 REMARK 410 Origin REMARK 410 Kabat REMARK 410 Common name REMARK 410 KAB REMARK 410 IMGT receptor type REMARK 410 IG REMARK 410 IMGT receptor description REMARK 410 (V-KAPPA) REMARK 410 Species REMARK 410 Homo sapiens (Human) REMARK 410 Chain ID REMARK 410 p00002_L REMARK 410 Common name REMARK 410 KAB REMARK 410 IMGT receptor type REMARK 410 IG REMARK 410 IMGT receptor description REMARK 410 (VH) REMARK 410 Species REMARK 410 Homo sapiens (Human) REMARK 410 Chain ID REMARK 410 p00002_H REMARK 410 REMARK 410 Chain ID p00002_L (P00002L) REMARK 410 IMGT chain description V-KAPPA REMARK 410 Chain amino acid sequence REMARK 410 [ V-REGION REMARK 410 DIVLTQSPGTLSLSPGERATLSCRASQSLSSTYLAWYQQKPGQAPRLLIYGASSRATGVPDRFSGS REMARK 410 ][ J-REGION ] REMARK 410 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGGGTKVEIKR REMARK 410 V-DOMAIN IMGT domain description V-KAPPA REMARK 410 V-DOMAIN IMGT gene and allele IGKV3-20*01 REMARK 410 V-DOMAIN IMGT gene and allele IGKJ4*01, IGKJ4*02 REMARK 410 V-DOMAIN CDR-IMGT length [7.3.9] REMARK 410 V-DOMAIN [ CDR1 ] REMARK 410 V-DOMAIN DIVLTQSPGTLSLSPGERATLSCRASQSLS.....STYLAWYQQKPGQAPRL REMARK 410 V-DOMAIN [ CDR2 ] REMARK 410 V-DOMAIN LIYGA.......SSRATGVP.DRFSGSG..SGTDFTLTISRLEPEDFAVYYC REMARK 410 V-DOMAIN [ CDR3 ] REMARK 410 V-DOMAIN QQYGS....SPFTFGGGTKVEIK REMARK 410 REMARK 410 Chain ID p00002_H (P00002H) REMARK 410 IMGT chain description VH REMARK 410 Chain amino acid sequence REMARK 410 [ V-REGION REMARK 410 QVHLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGQANYAQKFQG REMARK 410 ]N-AND-D-R[ J-REGION ] REMARK 410 RVTITADESTNTAYMELRSLRSDDTAMYYCAKEGYGDYGRPFDFWGQGTLVTVSS REMARK 410 V-DOMAIN IMGT domain description VH REMARK 410 V-DOMAIN IMGT gene and allele IGHV1-69*01, IGHV1-69*12, REMARK 410 V-DOMAIN IMGT gene and allele IGHV1-69*13 REMARK 410 V-DOMAIN IMGT gene and allele IGHJ4*01, IGHJ4*02, REMARK 410 V-DOMAIN IMGT gene and allele IGHJ4*03 REMARK 410 V-DOMAIN CDR-IMGT length [8.8.14] REMARK 410 V-DOMAIN [ CDR1 ] REMARK 410 V-DOMAIN QVHLVQSGA.EVKKPGSSVKVSCKASGGTF....SSYAISWVRQAPGQGLEW REMARK 410 V-DOMAIN [ CDR2 ] REMARK 410 V-DOMAIN MGGIIPI..FGQANYAQKFQ.GRVTITADESTNTAYMELRSLRSDDTAMYYC REMARK 410 V-DOMAIN [ CDR3 ] REMARK 410 V-DOMAIN AKEGYGDYGRPFDFWGQGTLVTVSS REMARK 410
This manual and the database it accompanies may be copied and redistributed freely, without advance permission, provided that this statement is reproduced with each copy.
Created : January 2010
IMGT founder and director: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr
Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr
Interface design: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr
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