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Papain digested immunoglobulin: 2 Fab and 1 Fc

IgG1 proteolytic cleavage by the papain gives two Fab fragments and a Fc fragment.

Fab Fab

VH corresponds to the V-D-J-REGION (in green (V), orange (DJ)) of the heavy chain.
VL corresponds to the V-J-REGION (in green (V) and yellow (J)) of the light chain.

The corresponding PDB (Protein Data Bank) format file is from Mike's immunoglobulin structure function site (

Created: 28/06/2001
Last updated: Monday, 20-Jan-2020 21:00:17 CET
Author: Marie-Paule Lefranc
Editors: Elodie Foulquier, Chantal Ginestoux