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Papain digested immunoglobulin: 2 Fab and 1 Fc

IgG1 proteolytic cleavage by the papain gives two Fab fragments and a Fc fragment.

Fab Fab

Fc

VH: V-DOMAIN of the immunoglobulin heavy chain
VL: V-DOMAIN of the immunoglobulin light chain
CH1, CH2, CH3: C-DOMAIN of the immunoglobulin heavy chain
CL: C-DOMAIN of the immunoglobulin light chain

VH corresponds to the V-D-J-REGION (in green (V), orange (DJ)) of the heavy chain.
VL corresponds to the V-J-REGION (in green (V) and yellow (J)) of the light chain.

The corresponding PDB (Protein Data Bank) format file is from Mike's immunoglobulin structure function site (http://www.umass.edu/microbio/rasmol/padlan.htm).

Created: 28/06/2001
Last updated: Thursday, 07-Aug-2025 21:00:48 CEST
Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Editors: Elodie Foulquier, Chantal Ginestoux