Hydrophobic pattern
The hydrophobic pattern refers to the positions of the IMGT Collier de Perles which have been shown to have an hydrophobic amino acid (hydropathy index with positive value: I, V, L, F, C, M, A) and/or Tryptophan (W) in more than 50 % of analysed IG and TR sequences (IMGT/LIGM-DB, V. Giudicelli and M.-P. Lefranc).
The hydrophobic pattern of the V-REGION comprises 41 positions
| FR-IMGT and CDR-IMGT | Strands and loops | Positions |
| FR1-IMGT | A | 4 |
| 11 | ||
| 12 | ||
| 13 | ||
| B | 19 | |
| 21 | ||
| 23 | ||
| 25 | ||
| FR2-IMGT | C | 39 |
| 40 | ||
| 41 | ||
| 46 (/P) | ||
| C' | 49 | |
| 50 (/P) | ||
| 52 | ||
| 53 | ||
| 54 | ||
| 55 | ||
| CDR2-IMGT | C'C" | 56 |
| FR3-IMGT | C" | 66 |
| 67 | ||
| 69 | ||
| 71 | ||
| D | 76 | |
| 78 | ||
| 80 | ||
| E | 86 | |
| 87 | ||
| 89 | ||
| 91 | ||
| 94 | ||
| 95 | ||
| 96 | ||
| F | 100 | |
| 101 | ||
| 103 | ||
| 104 | ||
| CDR3-IMGT | FG | 105 |
| 106 | ||
| 107 | ||
| 108 |
Positions are according to the IMGT unique
numbering for V-REGION
and shown in a representation of an IMGT Collier de Perles for
V-REGION.
Positions in agreement with the 'Hydrophobic pattern' are shown in blue in
IMGT Colliers de Perles of
the IMGT Repertoire and in those of
IMGT/3Dstructure-DB.
Other information:
See also: