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Hydrophobic pattern

The hydrophobic pattern refers to the positions of the IMGT Collier de Perles which have been shown to have an hydrophobic amino acid (hydropathy index with positive value: I, V, L, F, C, M, A) and/or Tryptophan (W) in more than 50 % of analysed IG and TR sequences (IMGT/LIGM-DB, V. Giudicelli and M.-P. Lefranc).

The hydrophobic pattern of the V-REGION comprises 41 positions

FR-IMGT and CDR-IMGT Strands and loops Positions
FR1-IMGT A 4
11
12
13
B 19
21
23
25
FR2-IMGT C 39
40
41
46 (/P)
C' 49
50 (/P)
52
53
54
55
CDR2-IMGT C'C" 56
FR3-IMGT C" 66
67
69
71
D 76
78
80
E 86
87
89
91
94
95
96
F 100
101
103
104
CDR3-IMGT FG 105
106
107
108

Positions are according to the IMGT unique numbering for V-REGION and shown in a representation of an IMGT Collier de Perles for V-REGION.
Positions in agreement with the 'Hydrophobic pattern' are shown in blue in IMGT Colliers de Perles of the IMGT Repertoire and in those of IMGT/3Dstructure-DB.

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