Immunoglobulins Overview

Proteins with known 3D structures
Overview: Human Immunoglobulins

Identification of the genes and alleles involved in the rearrangements and expressed in the variable regions

Protein display of the Ig V-D-J and V-J REGIONs

"OVERVIEW" gives information on proteins whose three-dimensional structure has been determined.
"IDENTIFICATION AND COLLIERS DE PERLES" provides

the identification of the genes and alleles expressed in the IGH V-DOMAINs (V-D-J-REGIONs) and in the IGK and IGL V-DOMAINs (V-J-REGIONs)

the Colliers de Perles of the IGH, IGK and IGL V-DOMAINs.
"PROTEIN DISPLAY" provides the Protein displays of the IGH, IGK and IGL V-DOMAINs.

Click here to see: Part 1 - Human immunoglobulin proteins (in alphabetic order)

Part 2 - Human immunoglobulin proteins (in the PDB code order)
Reference of this table: Ruiz, M. and Lefranc, M.-P., Immunogenetics, 53, 857-883 (2002) PMID:11862387, LIGM:259

Updates from 09/05/2001 are available in IMGT/3Dstructure-DB. IMGT/3Dstructure-DB entries (cards) are identified by the PDB code.
Click on a PDB code to get the corresponding IMGT/3Dstructure-DB card.

PDB Code
Protein Name
Fragment (1) Ligands Experimental Technique Resolution PDB Release Date References

1a8j
Mcg
L2
Aspartame
X-ray diffraction
2.70
17-jun-98
25

1adq
Rf-An
Fab
Autoantigen IgG Fc
X-ray diffraction
3.15
16-sep-98
21

1aqk
B7-15A2
Fab

X-ray diffraction
1.84
04-feb-98
26

1ar2
Rei
VL

X-ray diffraction
2.80
12-nov-97
24

1b0w
Bre
VL

X-ray diffraction
1.80
22-dec-99
31

1bjm
Loc
L2

X-ray diffraction
2.20
07-dec-95
19

1bre
Bre
VL

X-ray diffraction
2.00
15-oct-95
16

1bvk
HULYS11
Fv
Lysozyme [hen egg white]
X-ray diffraction
2.70
16-feb-99
27

1bvl
HULYS11
Fv

X-ray diffraction
2.87
16-feb-99
22

1bww
Reiv-T39K
VL

X-ray diffraction
1.70
29-dec-99
24

1cd0
Jto
(VL)2

X-ray diffraction
1.90
06-mar-00
36

1cz8
Fab-12
Fab
Vascular endothelial growth factor
X-ray diffraction
2.40
20-mar-00
33

1dcl
Mcg
L2

X-ray diffraction
2.30
15-may-97
5

1dee
IgmRf2A2
Fab

X-ray diffraction
2.70
14-jun-00
41

1dfb
3D6
Fab

X-ray diffraction
2.70
31-oct-93
10

1dql
Mez
Fv

X-ray diffraction
2.60
04-oct-00
44

1dl7
M3C65
Fv

X-ray diffraction
2.35
13-dec-00
39

1dx3
9E
Fv

theoretical model

15-dec-00
38

1e4k
Undefined
Fc
Fc gamma III low affinity receptor (CD16)
X-ray diffraction
3.20
06-aug-00
45

1eeq
M4L/Y(27D)D/T94H Mutant Of Len
(VL)2

X-ray diffraction
1.50
01-feb-01
51

1eeu
M4L/Y(27D)D/Q89D/T94H Mutant Of Len
(VL)2

X-ray diffraction
1.60
03-feb-01
51

1efq
Q38D Mutant Of Len
VL

X-ray diffraction
1.60
09-feb-01
51

1ek3
Rec
(VL)2

X-ray diffraction
1.90
06-mar-01
51

1f6a
Undefined
Fc
Fc epsilon RI alpha (high-affinity receptor)
X-ray diffraction
3.50
20-jul-00
40

1fc1
IgG1
Fc

X-ray diffraction
2.90
15-jul-92
3

1fc2
IgG1
Fc
Fragment B of protein A [Staphylococcus aureus]
X-ray diffraction
2.80
15-jul-92
3

1fh5
Mak33
Fab

X-ray diffraction
2.90
13-sep-00
47

1fp5
Ige Epsilon-1
Fc

X-ray diffraction
2.30
27-sep-00
46

1g84
IgE Cepsilon2
CH2

NMR, 15 structures

16-may-01
48

1g9n
17B
Fab
HIV-1 gp120 (envelope protein)/CD4
X-ray diffraction
2.90
27-dec-00
42

1g9m
17B
Fab
HIV-1 gp120 (envelope protein)/CD4
X-ray diffraction
2.20
27-dec-00
28

1gc1
17B
Fab
HIV-1 gp120 (envelope protein)/CD4
X-ray diffraction
2.50
19-aug-98
28

1hou
Undefined
Fv

theoretical model

23-dec-99
34

1iga
Iga1
IgA

theoretical model; scattering fitting

15-jun-99
32

1igm
Pot
Fv

X-ray diffraction
2.30
31-oct-93
9

1iis
IgG1
Fc
Fc gamma III low affinity receptor
X-ray diffraction
3.00
09-may-01
49

1iix
IgG1
Fc
Fc gamma III low affinity receptor
X-ray diffraction
3.50
09-may-01
49

1lil
Cle
L2

X-ray diffraction
2.65
15-may-97
20

1lve
Len
VL

X-ray diffraction
1.95
21-jan-98
23

1mcb
Mcg
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

1mcc
Mcg
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

1mcd
Mcg
L2
N-Acetyl-D-Phe-B-Ala-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
12

1mce
Mcg
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-OH
X-ray diffraction
2.70
31-jan-94
13

1mcf
Mcg
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH
X-ray diffraction
2.70
31-jan-94
12

1mch
Mcg
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH
X-ray diffraction
2.70
31-jan-94
13

1mci
Mcg
L2
N-Acetyl-D-Phe-L-His-D-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

1mcj
Mcg
L2
N-Acetyl-D-Phe-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

1mck
Mcg
L2
N-Acetyl-D-Glu-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

1mcl
Mcg
L2
N-Acetyl-D-His-L-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

1mcn
Mcg
L2
N-Acetyl-D-His-L-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

1mco
Mcg
Ig with a hinge deletion

X-ray diffraction
3.20
31-jan-94
14

1mcq
Mcg
L2
N-Acetyl-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

1mcr
Mcg
L2
N-Acetyl-L-His-D-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

1mcs
Mcg
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

1mcw
Mcg-Weir Hybrid
L2

X-ray diffraction
3.50
15-oct-90
7

1obe
3D6
Fab
HIV-1 gp41 synthetic peptide
theoretical model

15-may-97
17

1qac
Undefined
(VL)2

X-ray diffraction
1.80
23-feb-00
43

1qlr
Kau Cold Agglutinin
Fab

X-ray diffraction
2.83
14-sep-00
50

1qp1
Bre
(VL)3

X-ray diffraction
2.06
28-jun-99
37

1rei
Rei
(VL)2

X-ray diffraction
2.00
17-feb-84
1

1vge
Tr1.9
Fab

X-ray diffraction, single crystal
2.00
10-jun-96
18

1wtl
Wat
(VL)2

X-ray diffraction
1.90
01-nov-94
15

2cd0
Wil
(VL)2

X-ray diffraction
1.80
08-mar-00
36

2fb4
Kol
Fab

X-ray diffraction
1.90
12-jul-89
6

2ig2
Kol
Fab

X-ray diffraction
3.00
12-jul-89
6

2loi
Loi
(VL)2

theoretical model

29-dec-99
35

2lve
Len
VL

X-ray diffraction
2.70
18-may-99
29

2mcg
Mcg
L2

X-ray diffraction
2.00
15-jul-92
2

2rhe
Rhe
VL

X-ray diffraction
1.60
09-oct-88
4

3bjl
Loc
L2

X-ray diffraction
2.30
07-dec-95
19

3lve
Len (mutant)
VL

X-ray diffraction
2.00
18-may-99
30

3mcg
Mcg
L2

X-ray diffraction
2.00
15-oct-90
5

4bjl
Loc
L2

X-ray diffraction
2.40
07-dec-95
19

4lve
Len (mutant)
(VL)2

X-ray diffraction
2.30
18-may-99
29

5lve
Len
VL

X-ray diffraction
2.00
18-feb-00
30

7fab
Newm (2)
Fab

X-ray diffraction
2.00
31-jan-94
11

8fab
Hil
Fab

X-ray diffraction
1.80
31-oct-93
8

PDB Code	Protein Name	Fragment (1)	Ligands	Experimental Technique	Resolution	PDB Release Date	References
1a8j	Mcg	L2	Aspartame	X-ray diffraction	2.70	17-jun-98	25
1adq	Rf-An	Fab	Autoantigen IgG Fc	X-ray diffraction	3.15	16-sep-98	21
1aqk	B7-15A2	Fab		X-ray diffraction	1.84	04-feb-98	26
1ar2	Rei	VL		X-ray diffraction	2.80	12-nov-97	24
1b0w	Bre	VL		X-ray diffraction	1.80	22-dec-99	31
1bjm	Loc	L2		X-ray diffraction	2.20	07-dec-95	19
1bre	Bre	VL		X-ray diffraction	2.00	15-oct-95	16
1bvk	HULYS11	Fv	Lysozyme [hen egg white]	X-ray diffraction	2.70	16-feb-99	27
1bvl	HULYS11	Fv		X-ray diffraction	2.87	16-feb-99	22
1bww	Reiv-T39K	VL		X-ray diffraction	1.70	29-dec-99	24
1cd0	Jto	(VL)2		X-ray diffraction	1.90	06-mar-00	36
1cz8	Fab-12	Fab	Vascular endothelial growth factor	X-ray diffraction	2.40	20-mar-00	33
1dcl	Mcg	L2		X-ray diffraction	2.30	15-may-97	5
1dee	IgmRf2A2	Fab		X-ray diffraction	2.70	14-jun-00	41
1dfb	3D6	Fab		X-ray diffraction	2.70	31-oct-93	10
1dql	Mez	Fv		X-ray diffraction	2.60	04-oct-00	44
1dl7	M3C65	Fv		X-ray diffraction	2.35	13-dec-00	39
1dx3	9E	Fv		theoretical model		15-dec-00	38
1e4k	Undefined	Fc	Fc gamma III low affinity receptor (CD16)	X-ray diffraction	3.20	06-aug-00	45
1eeq	M4L/Y(27D)D/T94H Mutant Of Len	(VL)2		X-ray diffraction	1.50	01-feb-01	51
1eeu	M4L/Y(27D)D/Q89D/T94H Mutant Of Len	(VL)2		X-ray diffraction	1.60	03-feb-01	51
1efq	Q38D Mutant Of Len	VL		X-ray diffraction	1.60	09-feb-01	51
1ek3	Rec	(VL)2		X-ray diffraction	1.90	06-mar-01	51
1f6a	Undefined	Fc	Fc epsilon RI alpha (high-affinity receptor)	X-ray diffraction	3.50	20-jul-00	40
1fc1	IgG1	Fc		X-ray diffraction	2.90	15-jul-92	3
1fc2	IgG1	Fc	Fragment B of protein A [Staphylococcus aureus]	X-ray diffraction	2.80	15-jul-92	3
1fh5	Mak33	Fab		X-ray diffraction	2.90	13-sep-00	47
1fp5	Ige Epsilon-1	Fc		X-ray diffraction	2.30	27-sep-00	46
1g84	IgE Cepsilon2	CH2		NMR, 15 structures		16-may-01	48
1g9n	17B	Fab	HIV-1 gp120 (envelope protein)/CD4	X-ray diffraction	2.90	27-dec-00	42
1g9m	17B	Fab	HIV-1 gp120 (envelope protein)/CD4	X-ray diffraction	2.20	27-dec-00	28
1gc1	17B	Fab	HIV-1 gp120 (envelope protein)/CD4	X-ray diffraction	2.50	19-aug-98	28
1hou	Undefined	Fv		theoretical model		23-dec-99	34
1iga	Iga1	IgA		theoretical model; scattering fitting		15-jun-99	32
1igm	Pot	Fv		X-ray diffraction	2.30	31-oct-93	9
1iis	IgG1	Fc	Fc gamma III low affinity receptor	X-ray diffraction	3.00	09-may-01	49
1iix	IgG1	Fc	Fc gamma III low affinity receptor	X-ray diffraction	3.50	09-may-01	49
1lil	Cle	L2		X-ray diffraction	2.65	15-may-97	20
1lve	Len	VL		X-ray diffraction	1.95	21-jan-98	23
1mcb	Mcg	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
1mcc	Mcg	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
1mcd	Mcg	L2	N-Acetyl-D-Phe-B-Ala-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	12
1mce	Mcg	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-OH	X-ray diffraction	2.70	31-jan-94	13
1mcf	Mcg	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH	X-ray diffraction	2.70	31-jan-94	12
1mch	Mcg	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH	X-ray diffraction	2.70	31-jan-94	13
1mci	Mcg	L2	N-Acetyl-D-Phe-L-His-D-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
1mcj	Mcg	L2	N-Acetyl-D-Phe-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
1mck	Mcg	L2	N-Acetyl-D-Glu-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
1mcl	Mcg	L2	N-Acetyl-D-His-L-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
1mcn	Mcg	L2	N-Acetyl-D-His-L-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
1mco	Mcg	Ig with a hinge deletion		X-ray diffraction	3.20	31-jan-94	14
1mcq	Mcg	L2	N-Acetyl-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
1mcr	Mcg	L2	N-Acetyl-L-His-D-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
1mcs	Mcg	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
1mcw	Mcg-Weir Hybrid	L2		X-ray diffraction	3.50	15-oct-90	7
1obe	3D6	Fab	HIV-1 gp41 synthetic peptide	theoretical model		15-may-97	17
1qac	Undefined	(VL)2		X-ray diffraction	1.80	23-feb-00	43
1qlr	Kau Cold Agglutinin	Fab		X-ray diffraction	2.83	14-sep-00	50
1qp1	Bre	(VL)3		X-ray diffraction	2.06	28-jun-99	37
1rei	Rei	(VL)2		X-ray diffraction	2.00	17-feb-84	1
1vge	Tr1.9	Fab		X-ray diffraction, single crystal	2.00	10-jun-96	18
1wtl	Wat	(VL)2		X-ray diffraction	1.90	01-nov-94	15
2cd0	Wil	(VL)2		X-ray diffraction	1.80	08-mar-00	36
2fb4	Kol	Fab		X-ray diffraction	1.90	12-jul-89	6
2ig2	Kol	Fab		X-ray diffraction	3.00	12-jul-89	6
2loi	Loi	(VL)2		theoretical model		29-dec-99	35
2lve	Len	VL		X-ray diffraction	2.70	18-may-99	29
2mcg	Mcg	L2		X-ray diffraction	2.00	15-jul-92	2
2rhe	Rhe	VL		X-ray diffraction	1.60	09-oct-88	4
3bjl	Loc	L2		X-ray diffraction	2.30	07-dec-95	19
3lve	Len (mutant)	VL		X-ray diffraction	2.00	18-may-99	30
3mcg	Mcg	L2		X-ray diffraction	2.00	15-oct-90	5
4bjl	Loc	L2		X-ray diffraction	2.40	07-dec-95	19
4lve	Len (mutant)	(VL)2		X-ray diffraction	2.30	18-may-99	29
5lve	Len	VL		X-ray diffraction	2.00	18-feb-00	30
7fab	Newm (2)	Fab		X-ray diffraction	2.00	31-jan-94	11
8fab	Hil	Fab		X-ray diffraction	1.80	31-oct-93	8

IMGT notes:

(1) Fragment legend :

VH Ig heavy V-DOMAIN.

VL Ig light V-DOMAIN.

Fab Fragment antigen-binding. Complete light chain (Ig light V-DOMAIN and C-DOMAIN) disulfide-linked with an Ig heavy V-DOMAIN and CH1 C-DOMAIN.

Fv Ig heavy V-DOMAIN (VH) non covalently linked with an Ig light V-DOMAIN (VL).

Fc Fragment crystallizable. Two identical disulfide-linked Ig heavy CH2 and CH3 C-DOMAINs.

(VL)n n Ig light V-DOMAINs non covalently linked.

L2 Dimer of two non covalently linked complete light chains.

IgA Complete Immunoglobulin A.

scFv Two Ig (or by extension T cell receptor) V-DOMAINs covalently linked.

CH2 Ig heavy CH2 C-DOMAIN.

(2) Click here for "Particularities in protein designations: Human immunoglobulins: New and Newm "

Created: 26/06/2001
Last updated: Wednesday, 12-Jun-2024 16:02:20 CEST
Author: Manuel Ruiz

VH	Ig heavy V-DOMAIN.
VL	Ig light V-DOMAIN.
Fab	Fragment antigen-binding. Complete light chain (Ig light V-DOMAIN and C-DOMAIN) disulfide-linked with an Ig heavy V-DOMAIN and CH1 C-DOMAIN.
Fv	Ig heavy V-DOMAIN (VH) non covalently linked with an Ig light V-DOMAIN (VL).
Fc	Fragment crystallizable. Two identical disulfide-linked Ig heavy CH2 and CH3 C-DOMAINs.
(VL)n	n Ig light V-DOMAINs non covalently linked.
L2	Dimer of two non covalently linked complete light chains.
IgA	Complete Immunoglobulin A.
scFv	Two Ig (or by extension T cell receptor) V-DOMAINs covalently linked.
CH2	Ig heavy CH2 C-DOMAIN.