Immunoglobulins Overview

Proteins with known 3D structures
Overview: Human Immunoglobulins

Identification of the genes and alleles involved in the rearrangements and expressed in the variable regions

Protein display of the Ig V-D-J and V-J REGIONs

"OVERVIEW" gives information on proteins whose three-dimensional structure has been determined.
"IDENTIFICATION AND COLLIERS DE PERLES" provides

the identification of the genes and alleles expressed in the IGH V-DOMAINs (V-D-J-REGIONs) and in the IGK and IGL V-DOMAINs (V-J-REGIONs)

the Colliers de Perles of the IGH, IGK and IGL V-DOMAINs.
"PROTEIN DISPLAY" provides the Protein displays of the IGH, IGK and IGL V-DOMAINs.

Click here to see: Part 2 - Human immunoglobulin proteins (in the PDB code order)

Part 1 - Human immunoglobulin proteins (in alphabetic order)
Reference of this table: Ruiz, M. and Lefranc, M.-P., Immunogenetics, 53, 857-883 (2002) PMID:11862387, LIGM:259

Updates from 09/05/2001 are available in IMGT/3Dstructure-DB. IMGT/3Dstructure-DB entries (cards) are identified by the PDB code.
Click on a PDB code to get the corresponding IMGT/3Dstructure-DB card.

Protein Name
PDB Code
Fragment (1) Ligands Experimental Technique Resolution PDB Release Date References

17B
1g9m
Fab
HIV-1 gp120 (envelope protein)/CD4
X-ray diffraction
2.20
27-dec-00
28

17B
1g9n
Fab
HIV-1 gp120 (envelope protein)/CD4
X-ray diffraction
2.90
27-dec-00
42

17B
1gc1
Fab
HIV-1 gp120 (envelope protein)/CD4
X-ray diffraction
2.50
19-aug-98
28

3D6
1dfb
Fab

X-ray diffraction
2.70
31-oct-93
10

3D6
1obe
Fab
HIV-1 gp41 synthetic peptide
theoretical model

15-may-97
17

9E
1dx3
Fv

theoretical model

15-dec-00
38

B7-15A2
1aqk
Fab

X-ray diffraction
1.84
04-feb-98
26

Bre
1b0w
VL

X-ray diffraction
1.80
22-dec-99
31

Bre
1bre
VL

X-ray diffraction
2.00
15-oct-95
16

Bre
1qp1
(VL)3

X-ray diffraction
2.06
28-jun-99
37

Cle
1lil
L2

X-ray diffraction
2.65
15-may-97
20

Fab-12
1cz8
Fab
Vascular endothelial growth factor
X-ray diffraction
2.40
20-mar-00
33

HULYS11
1bvk
Fv
Lysozyme [hen egg white]
X-ray diffraction
2.70
16-feb-99
27

HULYS11
1bvl
Fv

X-ray diffraction
2.87
16-feb-99
22

Hil
8fab
Fab

X-ray diffraction
1.80
31-oct-93
8

IgE Cepsilon2
1g84
CH2

NMR, 15 structures

16-may-01
48

IgG1
1fc1
Fc

X-ray diffraction
2.90
15-jul-92
3

IgG1
1fc2
Fc
Fragment B of protein A [Staphylococcus aureus]
X-ray diffraction
2.80
15-jul-92
3

IgG1
1iis
Fc
Fc gamma III low affinity receptor
X-ray diffraction
3.00
09-may-01
49

IgG1
1iix
Fc
Fc gamma III low affinity receptor
X-ray diffraction
3.50
09-may-01
49

Iga1
1iga
IgA

theoretical model; scattering fitting

15-jun-99
32

Ige Epsilon-1
1fp5
Fc

X-ray diffraction
2.30
27-sep-00
46

IgmRf2A2
1dee
Fab

X-ray diffraction
2.70
14-jun-00
41

Jto
1cd0
(VL)2

X-ray diffraction
1.90
06-mar-00
36

Kau Cold Agglutinin
1qlr
Fab

X-ray diffraction
2.83
14-sep-00
50

Kol
2fb4
Fab

X-ray diffraction
1.90
12-jul-89
6

Kol
2ig2
Fab

X-ray diffraction
3.00
12-jul-89
6

Len (mutant)
3lve
VL

X-ray diffraction
2.00
18-may-99
30

Len (mutant)
4lve
(VL)2

X-ray diffraction
2.30
18-may-99
29

Len
1lve
VL

X-ray diffraction
1.95
21-jan-98
23

Len
2lve
VL

X-ray diffraction
2.70
18-may-99
29

Len
5lve
VL

X-ray diffraction
2.00
18-feb-00
30

Loc
1bjm
L2

X-ray diffraction
2.20
07-dec-95
19

Loc
3bjl
L2

X-ray diffraction
2.30
07-dec-95
19

Loc
4bjl
L2

X-ray diffraction
2.40
07-dec-95
19

Loi
2loi
(VL)2

theoretical model

29-dec-99
35

M3C65
1dl7
Fv

X-ray diffraction
2.35
13-dec-00
39

M4L/Y(27D)D/Q89D/T94H Mutant Of Len
1eeu
(VL)2

X-ray diffraction
1.60
03-feb-01
51

M4L/Y(27D)D/T94H Mutant Of Len
1eeq
(VL)2

X-ray diffraction
1.50
01-feb-01
51

Mak33
1fh5
Fab

X-ray diffraction
2.90
13-sep-00
47

Mcg-Weir Hybrid
1mcw
L2

X-ray diffraction
3.50
15-oct-90
7

Mcg
1a8j
L2
Aspartame
X-ray diffraction
2.70
17-jun-98
25

Mcg
1dcl
L2

X-ray diffraction
2.30
15-may-97
5

Mcg
1mcb
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mcc
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mcd
L2
N-Acetyl-D-Phe-B-Ala-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
12

Mcg
1mce
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-OH
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mcf
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH
X-ray diffraction
2.70
31-jan-94
12

Mcg
1mch
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mci
L2
N-Acetyl-D-Phe-L-His-D-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mcj
L2
N-Acetyl-D-Phe-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mck
L2
N-Acetyl-D-Glu-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mcl
L2
N-Acetyl-D-His-L-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mcn
L2
N-Acetyl-D-His-L-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mco
Ig with a hinge deletion

X-ray diffraction
3.20
31-jan-94
14

Mcg
1mcq
L2
N-Acetyl-L-His-D-Pro-NH2
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mcr
L2
N-Acetyl-L-His-D-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

Mcg
1mcs
L2
N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH
X-ray diffraction
2.70
31-jan-94
13

Mcg
2mcg
L2

X-ray diffraction
2.00
15-jul-92
2

Mcg
3mcg
L2

X-ray diffraction
2.00
15-oct-90
5

Mez
1dql
Fv

X-ray diffraction
2.60
04-oct-00
44

Newm (2)
7fab
Fab

X-ray diffraction
2.00
31-jan-94
11

Pot
1igm
Fv

X-ray diffraction
2.30
31-oct-93
9

Q38D Mutant Of Len
1efq
VL

X-ray diffraction
1.60
09-feb-01
51

Rec
1ek3
(VL)2

X-ray diffraction
1.90
06-mar-01
51

Rei
1ar2
VL

X-ray diffraction
2.80
12-nov-97
24

Rei
1rei
(VL)2

X-ray diffraction
2.00
17-feb-84
1

Reiv-T39K
1bww
VL

X-ray diffraction
1.70
29-dec-99
24

Rf-An
1adq
Fab
Autoantigen IgG Fc
X-ray diffraction
3.15
16-sep-98
21

Rhe
2rhe
VL

X-ray diffraction
1.60
09-oct-88
4

Tr1.9
1vge
Fab

X-ray diffraction, single crystal
2.00
10-jun-96
18

Undefined
1e4k
Fc
Fc gamma III low affinity receptor (CD16)
X-ray diffraction
3.20
06-aug-00
45

Undefined
1f6a
Fc
Fc epsilon RI alpha (high-affinity receptor)
X-ray diffraction
3.50
20-jul-00
40

Undefined
1hou
Fv

theoretical model

23-dec-99
34

Undefined
1qac
(VL)2

X-ray diffraction
1.80
23-feb-00
43

Wat
1wtl
(VL)2

X-ray diffraction
1.90
01-nov-94
15

Wil
2cd0
(VL)2

X-ray diffraction
1.80
08-mar-00
36

Protein Name	PDB Code	Fragment (1)	Ligands	Experimental Technique	Resolution	PDB Release Date	References
17B	1g9m	Fab	HIV-1 gp120 (envelope protein)/CD4	X-ray diffraction	2.20	27-dec-00	28
17B	1g9n	Fab	HIV-1 gp120 (envelope protein)/CD4	X-ray diffraction	2.90	27-dec-00	42
17B	1gc1	Fab	HIV-1 gp120 (envelope protein)/CD4	X-ray diffraction	2.50	19-aug-98	28
3D6	1dfb	Fab		X-ray diffraction	2.70	31-oct-93	10
3D6	1obe	Fab	HIV-1 gp41 synthetic peptide	theoretical model		15-may-97	17
9E	1dx3	Fv		theoretical model		15-dec-00	38
B7-15A2	1aqk	Fab		X-ray diffraction	1.84	04-feb-98	26
Bre	1b0w	VL		X-ray diffraction	1.80	22-dec-99	31
Bre	1bre	VL		X-ray diffraction	2.00	15-oct-95	16
Bre	1qp1	(VL)3		X-ray diffraction	2.06	28-jun-99	37
Cle	1lil	L2		X-ray diffraction	2.65	15-may-97	20
Fab-12	1cz8	Fab	Vascular endothelial growth factor	X-ray diffraction	2.40	20-mar-00	33
HULYS11	1bvk	Fv	Lysozyme [hen egg white]	X-ray diffraction	2.70	16-feb-99	27
HULYS11	1bvl	Fv		X-ray diffraction	2.87	16-feb-99	22
Hil	8fab	Fab		X-ray diffraction	1.80	31-oct-93	8
IgE Cepsilon2	1g84	CH2		NMR, 15 structures		16-may-01	48
IgG1	1fc1	Fc		X-ray diffraction	2.90	15-jul-92	3
IgG1	1fc2	Fc	Fragment B of protein A [Staphylococcus aureus]	X-ray diffraction	2.80	15-jul-92	3
IgG1	1iis	Fc	Fc gamma III low affinity receptor	X-ray diffraction	3.00	09-may-01	49
IgG1	1iix	Fc	Fc gamma III low affinity receptor	X-ray diffraction	3.50	09-may-01	49
Iga1	1iga	IgA		theoretical model; scattering fitting		15-jun-99	32
Ige Epsilon-1	1fp5	Fc		X-ray diffraction	2.30	27-sep-00	46
IgmRf2A2	1dee	Fab		X-ray diffraction	2.70	14-jun-00	41
Jto	1cd0	(VL)2		X-ray diffraction	1.90	06-mar-00	36
Kau Cold Agglutinin	1qlr	Fab		X-ray diffraction	2.83	14-sep-00	50
Kol	2fb4	Fab		X-ray diffraction	1.90	12-jul-89	6
Kol	2ig2	Fab		X-ray diffraction	3.00	12-jul-89	6
Len (mutant)	3lve	VL		X-ray diffraction	2.00	18-may-99	30
Len (mutant)	4lve	(VL)2		X-ray diffraction	2.30	18-may-99	29
Len	1lve	VL		X-ray diffraction	1.95	21-jan-98	23
Len	2lve	VL		X-ray diffraction	2.70	18-may-99	29
Len	5lve	VL		X-ray diffraction	2.00	18-feb-00	30
Loc	1bjm	L2		X-ray diffraction	2.20	07-dec-95	19
Loc	3bjl	L2		X-ray diffraction	2.30	07-dec-95	19
Loc	4bjl	L2		X-ray diffraction	2.40	07-dec-95	19
Loi	2loi	(VL)2		theoretical model		29-dec-99	35
M3C65	1dl7	Fv		X-ray diffraction	2.35	13-dec-00	39
M4L/Y(27D)D/Q89D/T94H Mutant Of Len	1eeu	(VL)2		X-ray diffraction	1.60	03-feb-01	51
M4L/Y(27D)D/T94H Mutant Of Len	1eeq	(VL)2		X-ray diffraction	1.50	01-feb-01	51
Mak33	1fh5	Fab		X-ray diffraction	2.90	13-sep-00	47
Mcg-Weir Hybrid	1mcw	L2		X-ray diffraction	3.50	15-oct-90	7
Mcg	1a8j	L2	Aspartame	X-ray diffraction	2.70	17-jun-98	25
Mcg	1dcl	L2		X-ray diffraction	2.30	15-may-97	5
Mcg	1mcb	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mcc	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mcd	L2	N-Acetyl-D-Phe-B-Ala-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	12
Mcg	1mce	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-OH	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mcf	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH	X-ray diffraction	2.70	31-jan-94	12
Mcg	1mch	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mci	L2	N-Acetyl-D-Phe-L-His-D-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mcj	L2	N-Acetyl-D-Phe-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mck	L2	N-Acetyl-D-Glu-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mcl	L2	N-Acetyl-D-His-L-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mcn	L2	N-Acetyl-D-His-L-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mco	Ig with a hinge deletion		X-ray diffraction	3.20	31-jan-94	14
Mcg	1mcq	L2	N-Acetyl-L-His-D-Pro-NH2	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mcr	L2	N-Acetyl-L-His-D-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
Mcg	1mcs	L2	N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH	X-ray diffraction	2.70	31-jan-94	13
Mcg	2mcg	L2		X-ray diffraction	2.00	15-jul-92	2
Mcg	3mcg	L2		X-ray diffraction	2.00	15-oct-90	5
Mez	1dql	Fv		X-ray diffraction	2.60	04-oct-00	44
Newm (2)	7fab	Fab		X-ray diffraction	2.00	31-jan-94	11
Pot	1igm	Fv		X-ray diffraction	2.30	31-oct-93	9
Q38D Mutant Of Len	1efq	VL		X-ray diffraction	1.60	09-feb-01	51
Rec	1ek3	(VL)2		X-ray diffraction	1.90	06-mar-01	51
Rei	1ar2	VL		X-ray diffraction	2.80	12-nov-97	24
Rei	1rei	(VL)2		X-ray diffraction	2.00	17-feb-84	1
Reiv-T39K	1bww	VL		X-ray diffraction	1.70	29-dec-99	24
Rf-An	1adq	Fab	Autoantigen IgG Fc	X-ray diffraction	3.15	16-sep-98	21
Rhe	2rhe	VL		X-ray diffraction	1.60	09-oct-88	4
Tr1.9	1vge	Fab		X-ray diffraction, single crystal	2.00	10-jun-96	18
Undefined	1e4k	Fc	Fc gamma III low affinity receptor (CD16)	X-ray diffraction	3.20	06-aug-00	45
Undefined	1f6a	Fc	Fc epsilon RI alpha (high-affinity receptor)	X-ray diffraction	3.50	20-jul-00	40
Undefined	1hou	Fv		theoretical model		23-dec-99	34
Undefined	1qac	(VL)2		X-ray diffraction	1.80	23-feb-00	43
Wat	1wtl	(VL)2		X-ray diffraction	1.90	01-nov-94	15
Wil	2cd0	(VL)2		X-ray diffraction	1.80	08-mar-00	36

IMGT notes:

(1) Fragment legend :

VH Ig heavy V-DOMAIN.

VL Ig light V-DOMAIN.

Fab Fragment antigen-binding. Complete light chain (Ig light V-DOMAIN and C-DOMAIN) disulfide-linked with an Ig heavy V-DOMAIN and CH1 C-DOMAIN.

Fv Ig heavy V-DOMAIN (VH) non covalently linked with an Ig light V-DOMAIN (VL).

Fc Fragment crystallizable. Two identical disulfide-linked Ig heavy CH2 and CH3 C-DOMAINs.

(VL)n n Ig light V-DOMAINs non covalently linked.

L2 Dimer of two non covalently linked complete light chains.

IgA Complete Immunoglobulin A.

scFv Two Ig (or by extension T cell receptor) V-DOMAINs covalently linked.

CH2 Ig heavy CH2 C-DOMAIN.

(2) Click here for "Particularities in protein designations: Human immunoglobulins: New and Newm "

Created: 26/06/2001
Last updated: Wednesday, 12-Jun-2024 16:02:20 CEST
Author: Manuel Ruiz

VH	Ig heavy V-DOMAIN.
VL	Ig light V-DOMAIN.
Fab	Fragment antigen-binding. Complete light chain (Ig light V-DOMAIN and C-DOMAIN) disulfide-linked with an Ig heavy V-DOMAIN and CH1 C-DOMAIN.
Fv	Ig heavy V-DOMAIN (VH) non covalently linked with an Ig light V-DOMAIN (VL).
Fc	Fragment crystallizable. Two identical disulfide-linked Ig heavy CH2 and CH3 C-DOMAINs.
(VL)n	n Ig light V-DOMAINs non covalently linked.
L2	Dimer of two non covalently linked complete light chains.
IgA	Complete Immunoglobulin A.
scFv	Two Ig (or by extension T cell receptor) V-DOMAINs covalently linked.
CH2	Ig heavy CH2 C-DOMAIN.