Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

For a given gene name, each horizontal line corresponds to a different allele. For more information, see Alignments of alleles and Tables of alleles (IMGT Repertoire).

IGLV gene names are designated by a number for the subgroup [1,23,24], followed by a dash and a number for the localization from 3' to 5' in the locus.
In the IGLV gene name column, the IGLV genes are listed, for each subgroup, according to their position from 3' to 5' in the locus.
Pseudogenes which could not be assigned to subgroups with functional genes are designated by a roman number between parentheses, corresponding to the clans [26], followed by a dash and a number for the localization from 3' to 5' in the locus.

The 11 human (Homo sapiens) IGLV subgroups belong to five clans (Figure IGLV clans). Two additional clans only contain pseudogenes. Clans comprise, respectively:

Gene table of human (Homo sapiens) IGLV IMGT group:
IMGT sub­groupIMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		R T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)
IGLV1IGLV1-36 IGLV1-36*01 (42) F 22q11.2
RTPr
++
 V1-11 D87010 [23] MAP 30736-31242 BK075720✤ [27] 428537-429043
BK075721✤ [27] 428545-429051
V1-11 D87009 [23] 13275-13570 *
IMGT000225 [10,25] ° 415923-416429
IMGT000280 [29] ° 431868-432374
IMGT000293 [8,20] 428552-429058
lv1c2 U03900 [14] 188-483 *
lv1c2c U03901 [14] 188-483 *
DPL1 Z22187 [41] 1-294 *
1a(1a.11.2) Z73653 [17,42] 1-296 *
IGLV1IGLV1-40 IGLV1-40*01 (42) F 22q11.2
RTPr
++
 V1-13 D87010 [23] MAP 8551-9055 BK075720✤ [27] 406357-406861
BK075721✤ [27] 406354-406858
IMGT000225 [10,25] ° 393742-394246
IMGT000280 [29] ° 409660-410164
IMGT000293 [8,20] 406369-406873
Humlv1042 M94116 [13] 242-540 *
DPL8 Z22194 [41] 1-297 *
1e(1e.10.2) Z73656 [17,42] 1-299 *
IGLV1IGLV1-40 IGLV1-40*02 (42) F 22q11.2
RTPr
++
 Vlambda1.2(IGLV1S2) X53936 [4] 189-487 * DPL7 Z22193 [41] 1-297 *
IGLV1IGLV1-40 IGLV1-40*03 (42) F 22q11.2
RTPr
++
 DPL6 Z22192 [41] 1-297 *
IGLV1IGLV1-41 IGLV1-41*01 (42) ORF (43) 22q11.2 Humlv1041 M94118 [13] MAP 401-696 * BK075721✤ [27] 400796-401296
Vlambda1.1(IGLV1S1) X14615 [1] 266-561 *
DPL4 Z22212 [41] 1-294 *
1d(1d.8.3) Z73655 [17,42] 1-296 *
IGLV1IGLV1-41 IGLV1-41*02 (42) P (44) 22q11.2 V1-14P D87010 [23] MAP 3160-3455 * BK075720✤ [27] 400800-401300
IMGT000225 [10,25] ° 388185-388685
IMGT000280 [29] ° 404102-404602
IMGT000293 [8,20] 400812-401312
IGLV1IGLV1-44 IGLV1-44*01 (42) F 22q11.2
RTPr
++
 AC279207 [32] MAP 38731-39237 BK075720✤ [27] 377455-377961
BK075721✤ [27] 377451-377957
V1-16 D86999 [23] 20558-20853 *
IMGT000225 [10,25] ° 364805-365311
IMGT000280 [29] ° 371627-372133
IMGT000293 [8,20] 377441-377947
lv1L1a U03902 [14] 188-483 *
Humlv1L1 X59707 [13,30] 197-492 *
DPL2 Z22188 [41] 1-294 *
1c(1c.10.2) Z73654 [17,42] 1-296 *
IGLV1IGLV1-44 IGLV1-44*02 (42) F 22q11.2 MW316667 [28] 89-594
IGLV1IGLV1-44 IGLV1-44*03 (42) F 22q11.2 MW316668 [28] 87-593
IGLV1IGLV1-44 IGLV1-44*04 F 22q11.2 ABC10_2_1_000044093800_G12 OL352719 [31] 38396-38902
IGLV1IGLV1-47 IGLV1-47*01 (42) F 22q11.2
RTPr
++
 IMGT000280 [29] ° MAP 348545-349051 BK075720✤ [27] 348349-348855
BK075721✤ [27] 348345-348851
IMGT000293 [8,20] 354374-354880
Humlv122 M94114 [13] 130-425 *
ABC10_2_1_000044093800_G12 OL352719 [31] 15344-15850
DPL3 Z22189 [41] 1-294 *
1g(1g.400B5) Z73663 [17,42] 1-296 *
IGLV1IGLV1-47 IGLV1-47*02 (42) F 22q11.2
RTPr
++
 V1-17 D87016 [23] MAP 27990-28285 * IMGT000225 [10,25] ° 341720-342226
IGLV1IGLV1-47 IGLV1-47*03 (42) F 22q11.2 ABC13_11_000048870800_F24 AC279207 [32] 15634-16140
IGLV1IGLV1-50 IGLV1-50*01 (42) ORF (45) 22q11.2
RTPr
+
 Humlv101 M94112 [13] MAP 287-585 * BK075720✤ [27] 317910-318414
BK075721✤ [27] 317906-318410
V1-18 D87018 [23] 23430-23728 *
IMGT000225 [10,25] ° 311276-311780
IMGT000280 [29] ° 318122-318626
IMGT000293 [8,20] 323933-324437
DPL9 Z22195 [41] 1-297 *
1f(1f.366F5) Z73662 [17,42] 1-299 *
IGLV1IGLV1-51 IGLV1-51*01 (42) F 22q11.2
RTPr
++
 V1-19 D87018 [23] MAP 18418-18918 BK075720✤ [27] 313064-313564
BK075721✤ [27] 313060-313560
IMGT000225 [10,25] ° 306433-306933
IMGT000280 [29] ° 313276-313776
IMGT000293 [8,20] 319088-319588
lv117d U03870 [15] 193-488 *
DPL5 Z22191 [41] 1-294 *
1b(1b.366F5) Z73661 [17,42] 1-296 *
IGLV1IGLV1-51 IGLV1-51*02 (42) F 22q11.2
RTPr
++
 Humlv117 M30446 [34] 55-350 *
IGLV1IGLV1-62 IGLV1-62*01 (46) P (1) 22q11.2 V1-23P D87022 [23] MAP 20165-20667 BK075720✤ [27] 77160-77662
BK075721✤ [27] 77160-77662
IMGT000225 [10,25] ° 70486-70988
IMGT000280 [29] ° 77140-77642
IGLV1IGLV1-62 IGLV1-62*02 P 22q11.2 IMGT000293 [8,20] MAP 77158-77660
IGLV1IGLV1-67-1 IGLV1-67-1*01 P (2) 22q11.2 IMGT000225 [10,25] ° MAP 22568-23050 BK075720✤ [27] 29229-29711
BK075721✤ [27] 29231-29713
IMGT000280 [29] ° 29229-29711
IMGT000293 [8,20] 29227-29709
IGLV2IGLV2-5 IGLV2-5*01 (47) P (3) 22q11.2 IMGT000312 [8,20] MAP 847302-847811 V1-1P D87024 [23] 23852-24361
IMGT000225 [10,25] ° 840515-841024
IMGT000280 [29] ° 856498-857007
lv2120 L27696 [11,21] 175-472 *
DPL15 Z22201 [24,41] 1-297 *
2a1(2a1.51E6) Z73641 [17,42] 1-298 *
IGLV2IGLV2-5 IGLV2-5*02 (47) P (4) 22q11.2 psiVlambdaII.1 X57825 [11] MAP 185-695 IMGT000293 [8,20] 853121-853630
IGLV2IGLV2-5 IGLV2-5*03 P (5) 22q11.2 BK075720✤ [27] MAP 852785-853294
IGLV2IGLV2-5 IGLV2-5*04 P (6) 22q11.2 BK075721✤ [27] MAP 852694-853203
IGLV2IGLV2-8 IGLV2-8*01 (47) F 22q11.2
RTPr
++
 IMGT000312 [8,20] MAP 813533-814040 AC279221 [32] 32037-32544
BK075720✤ [27] 819333-819840
BK075721✤ [27] 819242-819749
V1-2 D87021 [23] 23248-23544 *
IMGT000225 [10,25] ° 806746-807253
IMGT000280 [29] ° 822732-823239
IMGT000293 [8,20] 819356-819863
2c(2c.118D9) X97462 [42] 1-297 *
EKL2046 Y12417 [3] <1->274 *
IGLV2IGLV2-8 IGLV2-8*02 (47) F 22q11.2
RTPr
++
 lv2046 L27695 [21] 173-469 *
IGLV2IGLV2-8 IGLV2-8*03 (47) F 22q11.2 RXL2046 Y12418 [3] <1->274 *
IGLV2IGLV2-8 IGLV2-8*04 F 22q11.2 ABC11_000047169400_D9 OL352721 [31] 38880-39387
IGLV2IGLV2-11 IGLV2-11*01 (47) F 22q11.2
RTPr
++
 174779_ABC12_000046886900_P4 AC279423 [31] MAP 40444-40953 AC279221 [32] 1746-2255
BK075720✤ [27] 789043-789552
BK075721✤ [27] 788949-789458
V1-3 D86998 [23] 30539-30835 *
IMGT000225 [10,25] ° 776458-776967
IMGT000280 [29] ° 792444-792953
IMGT000293 [8,20] 789066-789575
EKL12 Y12414 [3] <1->274 *
2e(2e.2.2) Z73657 [17,42] 1-297 *
IGLV2IGLV2-11 IGLV2-11*02 (47) F 22q11.2
RTPr
++
 DPL12 Z22198 [41] 1-297 *
IGLV2IGLV2-11 IGLV2-11*03 (47) F 22q11.2
RTPr
++
 RXL12 Y12415 [3] <1->274 *
IGLV2IGLV2-14 IGLV2-14*01 (47) F 22q11.2
RTPr
++
 V1-4 D87015 [23] MAP 28589-29098 IMGT000225 [10,25] ° 742666-743175
lv215.23 L27693 [21,41] 175-471 *
DPL11 Z22197 [41] 1-297 *
2a2(2a2.272A12) Z73664 [17,42] 1-297 *
IGLV2IGLV2-14 IGLV2-14*02 (47) F 22q11.2
RTPr
++
 lv2018 L27822 [5,21,41] 175-471 *
IGLV2IGLV2-14 IGLV2-14*03 (47) F 22q11.2
RTPr
++
 174779_ABC12_000046886900_P4 AC279423 [31] MAP 6759-7268 BK075720✤ [27] 755340-755849
IMGT000293 [8,20] 755372-755881
IGLV2-14*01_S5228 MK308863 [39] (48) #c 1-297 *
EKL11 Y12412 [3] <1->274 *
IGLV2IGLV2-14 IGLV2-14*04 (47) F 22q11.2
RTPr
++
 IMGT000280 [29] ° MAP 758747-759256 BK075721✤ [27] 755250-755759
RXL11 Y12413 [3] <1->274 *
IGLV2IGLV2-14 IGLV2-14*05 (47) F 22q11.2 MW316674 [28] 169-678
IGLV2IGLV2-18 IGLV2-18*01 (47) F 22q11.2
RTPr
++
 V1-5 D87007 [23] MAP 35038-35546 V1-5 D87015 [23] 4640-4936 *
IMGT000225 [10,25] ° 718545-719053
IMGT000280 [29] ° 734624-735132
lv2132 L27689 [21,41] 174-470 *
DPL13 Z22199 [41] 1-297 *
2d(2d.29D11) Z73642 [17,42] 1-297 *
IGLV2IGLV2-18 IGLV2-18*02 (47) F 22q11.2
RTPr
++
 IMGT000312 [8,20] MAP 725308-725816 AC279210 [32] 36046-36554
BK075720✤ [27] 731248-731756
BK075721✤ [27] 731181-731689
IMGT000293 [8,20] 731265-731773
lv216.21 L27697 [21,41] 88-384 *
RLX13 Y12416 [3] <1->274 *
IGLV2IGLV2-18 IGLV2-18*03 (47) F 22q11.2
RTPr
++
 lv2007 L27694 [21] 177-473 *
IGLV2IGLV2-18 IGLV2-18*04 (47) F 22q11.2
RTPr
++
 lv2113 L27692 [21] 174-470 *
IGLV2IGLV2-23 IGLV2-23*01 (47) F 22q11.2
RTPr
++
 Vlambda2.1(IGLV2S1) X14616 [5] 276-573 *
IGLV2IGLV2-23 IGLV2-23*02 (47) F 22q11.2
RTPr
++
 IMGT000280 [29] ° MAP 697954-698463 AC279208 [32] 2742-3251
AC279213 [32] 27293-27802
AC279219 [32] 2742-3251
BK075720✤ [27] 694579-695088
IMGT000293 [8,20] 694591-695100
EKL10 Y12411 [3] <1->274 *
2b2(2b2.400B5) Z73665 [17,42] 1-297 *
IGLV2IGLV2-23 IGLV2-23*03 (47) F 22q11.2
RTPr
++
 V1-7 D86994 [23] MAP 35601-35897 * BK075721✤ [27] 694501-695010
IMGT000225 [10,25] ° 681876-682385
v2066 L27688 [5,21,41] 175-471 *
DPL10 Z22196 [41] 1-297 *
IGLV2IGLV2-23 IGLV2-23*04 F 22q11.2 ABC13_11_000048923500_G11 OL352727 [31] 22122-22631
IGLV2IGLV2-23 IGLV2-23*05 F 22q11.2 IMGT000312 [8,20] MAP 688657-689166
IGLV2IGLV2-28 IGLV2-28*01 (47) P (7) 22q11.2 ABC11_000047999300_E7 AC279318 [32] MAP 9561-10058 BK075720✤ [27] 661145-661642
BK075721✤ [27] 661028-661525
V1-8P D86994 [23] 2108-2392 *
IMGT000225 [10,25] ° 648398-648895
IMGT000280 [29] ° 664523-665020
IMGT000293 [8,20] 661138-661635
2b1(2b1.22E4) X97466 [42] 1-285 *
IGLV2IGLV2-33 IGLV2-33*01 (47) ORF (49) 22q11.2 V1-9 D87014 [23] MAP 5824-6120 * BK075720✤ [27] 584608-585122
BK075721✤ [27] 584551-585065
IMGT000225 [10,25] ° 572138-572652
IMGT000280 [29] ° 588157-588453 *
IMGT000293 [8,20] 584593-585107
lv2011 L27687 [21,41] 180-476 *
DPL14 Z22200 [41] 1-297 *
2f(2f.61E11) Z73643 [17,42] 1-297 *
IGLV2IGLV2-33 IGLV2-33*02 (47) ORF (49) 22q11.2 lv2110 L27823 [5,21,41] 175-471 *
IGLV2IGLV2-33 IGLV2-33*03 (47) ORF (49) 22q11.2 lv2031 L27691 [21] 180-476 *
IGLV2IGLV2-34 IGLV2-34*01 (47) P (50) 22q11.2 V1-10P D87013 [23] 30323-30619 * lv216.376 L27690 [11,21] 301-598 *
IGLV2IGLV2-34 IGLV2-34*02 (47) P (2) 22q11.2 IMGT000225 [10,25] ° MAP 563767-564275 BK075720✤ [27] 576352-576860
IMGT000280 [29] ° 579714-580222
IMGT000293 [8,20] 576333-576841
DPL25, IGLV2-NL1 Z22209 [41] 1-297 *
IGLV2IGLV2-34 IGLV2-34*03 P (2) 22q11.2 BK075721✤ [27] MAP 576371-576879
IGLV3IGLV3-1 IGLV3-1*01 (47) F 22q11.2
RTPr
++
 VLIII.1 X57826 [11] MAP 2256-2540 * BK075720✤ [27] 877148-877667
BK075721✤ [27] 876991-877510
V2-1 D87023 [23] 6707-6991 *
IMGT000225 [10,25] ° 864683-865356
IMGT000280 [29] ° 880701-881374
IMGT000293 [8,20] 877301-877974
DPL23 Z22208 [41] 1-285 *
3r(3r.9C5) Z73647 [17,42] 1-285 *
IGLV3IGLV3-1 IGLV3-1*02 F 22q11.2 ABC11_2_1_000048325700_N20 OL352728 [31] 13089-13608
IGLV3IGLV3-2 IGLV3-2*01 (47) P (8) 22q11.2 3q(3q.127E5) X97468 [42] 1-284 *
IGLV3IGLV3-2 IGLV3-2*02 (47) P (51) 22q11.2 psiVlambdaN.1 X57828 [11] 1837-2121 * V2-2P D87024 [23] 40476-40759 *
IGLV3IGLV3-2 IGLV3-2*03 P (9) 22q11.2 ABC11_2_1_000048325700_N20 OL352728 [31] MAP 5154-5678 BK075720✤ [27] 869215-869739
BK075721✤ [27] 869120-869644
IMGT000225 [10,25] ° 856933-857457
IMGT000280 [29] ° 872916-873440
IMGT000293 [8,20] 869551-870075
IGLV3IGLV3-4 IGLV3-4*01 (47) P (52) 22q11.2 V2-3P D87024 [23] MAP 25285-25564 * IMGT000225 [10,25] ° 841746-842266
IMGT000280 [29] ° 857729-858249
IMGT000293 [8,20] 854352-854872
IGLV3IGLV3-4 IGLV3-4*02 ORF (10) 22q11.2 BK075720✤ [27] MAP 854016-854536
IGLV3IGLV3-4 IGLV3-4*03 ORF (11) 22q11.2 BK075721✤ [27] MAP 853925-854445
IGLV3IGLV3-6 IGLV3-6*01 (47) P (12) 22q11.2 IMGT000225 [10,25] ° MAP 834095-834620 BK075720✤ [27] 846365-846890
BK075721✤ [27] 846272-846797
V2-4P D87024 [23] 17635-17918 *
IMGT000280 [29] ° 850077-850602
IMGT000293 [8,20] 846701-847226
3a2(3a2.51E6) X97465 [42] 1-284 *
IGLV3IGLV3-6 IGLV3-6*02 (47) P (13) 22q11.2 psiVlambdaIII.2 X57827 [11] 484-1005
IGLV3IGLV3-7 IGLV3-7*01 (47) P (8) 22q11.2 3n(3n.118D9) X97470 [42] MAP 1-288 * V2-5P D87024 [23] 5865-6152 *
IMGT000225 [10,25] ° 822526-822813 *
IGLV3IGLV3-7 IGLV3-7*02 P (14) 22q11.2 IMGT000280 [29] ° MAP 838305-838835 BK075721✤ [27] 834499-835029
IMGT000293 [8,20] 834929-835459
IGLV3IGLV3-7 IGLV3-7*03 P (15) 22q11.2 BK075720✤ [27] MAP 834595-835125
IGLV3IGLV3-9 IGLV3-9*01 (47) F 22q11.2
RTPr
++
 AC279221 [32] MAP 28343-29007 BK075720✤ [27] 815637-816303
BK075721✤ [27] 815548-816212
V2-6 D87021 [23] 19726-20010 *
IMGT000225 [10,25] ° 803050-803716
IMGT000280 [29] ° 819379-819663 *
IMGT000293 [8,20] 815660-816326
3j(3j.118D9) X97473 [42] 1-285 *
IGLV3IGLV3-9 IGLV3-9*02 (47) F 22q11.2
RTPr
++
 IGLV3S6 X74288 [18] MAP 354-643 *
IGLV3IGLV3-9 IGLV3-9*03 (47) P (16) 22q11.2
RTPr
+
 psiVlambda1 X51754 [38] #g 1914-2197 *
IGLV3IGLV3-10 IGLV3-10*01 (47) F 22q11.2
RTPr
++
 V2-7 D87021 [23] MAP 12040-12578 BK075720✤ [27] 808294-808832
IMGT000225 [10,25] ° 795707-796245
IMGT000280 [29] ° 811693-812231
IMGT000293 [8,20] 808317-808855
3p(3p.81A4) X97464 [42] 1-290 *
IGLV3IGLV3-10 IGLV3-10*02 (47) F 22q11.2
RTPr
++
 IGGLL295 L29166 [16] 241->525 *
IGLV3IGLV3-10 IGLV3-10*03 (47) F 22q11.2 ABC13_11_000047484300_J24 AC279221 [32] 21000-21538
IGLV3IGLV3-10 IGLV3-10*04 F 22q11.2 BK075721✤ [27] MAP 808205-808743
IGLV3IGLV3-12 IGLV3-12*01 (47) P (17) 22q11.2
RTPr
++
 174779_ABC12_000046886900_P4 AC279423 [31] MAP 19769-20557 BK075720✤ [27] 768351-769139
IMGT000293 [8,20] 768383-769171
3i(3i.2.2) Z73658 [17,42] (53) 1-290 *
IGLV3IGLV3-12 IGLV3-12*02 (47) F 22q11.2
RTPr
+
 V2-8 D86998 [23] MAP 10129-10418 * BK075721✤ [27] 768256-769045
IMGT000225 [10,25] ° 755758-756546
IMGT000280 [29] ° 771747-772535
IGLV3IGLV3-13 IGLV3-13*01 (47) P (18) 22q11.2 IMGT000225 [10,25] ° MAP 746004-746538 V2-9P D86998 [23] 127-410 *
3f(3f.119B4) X97463 [42] 1-284 *
IGLV3IGLV3-13 IGLV3-13*02 (47) P (19) 22q11.2 174779_ABC12_000046886900_P4 AC279423 [31] MAP 10012-10547 BK075720✤ [27] 758593-759128
IMGT000293 [8,20] 758625-759160
IGLV3IGLV3-13 IGLV3-13*03 P (18) 22q11.2 IMGT000280 [29] ° MAP 761984-762519 BK075721✤ [27] 758493-759028
IGLV3IGLV3-15 IGLV3-15*01 (47) P (52) 22q11.2 V2-10P D87015 [23] MAP 25401-25685 * 174779_ABC12_000046886900_P4 AC279423 [31] 3262-3931
BK075720✤ [27] 751988-752511
IMGT000225 [10,25] ° 739132-739801
IMGT000293 [8,20] 752020-752543
IGLV3IGLV3-15 IGLV3-15*02 P (14) 22q11.2 IMGT000280 [29] ° MAP 755395-755918 BK075721✤ [27] 751898-752421
IGLV3IGLV3-15 IGLV3-15*03 P (14) 22q11.2 IMGT000312 [8,20] MAP 746058-746580
IGLV3IGLV3-16 IGLV3-16*01 (47) F 22q11.2
RTPr
++
 V2-11 D87015 [23] MAP 17267-17806 BK075720✤ [27] P (62) 744049-744586
BK075721✤ [27] P (62) 743976-744513
IMGT000225 [10,25] ° 731346-731885
IMGT000280 [29] P (62) ° 747418-747955
IMGT000293 [8,20] P (62) 744066-744603
3a(3a.119B4) X97471 [42] 1-290 *
IGLV3IGLV3-17 IGLV3-17*01 (47) P (20) 22q11.2 Humlv413 M94117 [12] MAP 22-535 BK075720✤ [27] 735346-735859
BK075721✤ [27] 735279-735792
V2-12P D87015 [23] 8758-9038 *
IMGT000225 [10,25] ° 722642-723155
IMGT000280 [29] ° 738721-739234
IMGT000293 [8,20] 735363-735876
3g(3g.29D11) X97472 [42] 1-281 *
IGLV3IGLV3-19 IGLV3-19*01 (47) F 22q11.2
RTPr
++
 Vlambda3.1(IGLV3S1) X56178 [19] MAP 201-490 * AC279210 [32] 22097-22628
BK075720✤ [27] 717286-717817
BK075721✤ [27] 717208-717739
IMGT000225 [10,25] ° 704588-705119
IMGT000280 [29] ° 720667-721198
IMGT000293 [8,20] 717301-717832
IGLV3IGLV3-19 IGLV3-19*02 (47) F 22q11.2 ABC10_2_1_000044078800_J23 AC279208 [32] MAP 25444-25975 AC279219 [32] 25444-25975
IGLV3IGLV3-21 IGLV3-21*01 (47) F 22q11.2
RTPr
++
 IGLV3S2 X71966 [18] 688-977 *
IGLV3IGLV3-21 IGLV3-21*02 (47) F 22q11.2
RTPr
++
 V2-14 D87007 [23] MAP 13325-13614 * IMGT000225 [10,25] ° 696344-697163
IMGT000280 [29] ° 712423-713242
IGLV3IGLV3-21 IGLV3-21*03 (47) F 22q11.2
RTPr
++
 Humlv318 M94115 [12] 637-926 *
IGLV3IGLV3-21 IGLV3-21*04 (47) F 22q11.2
RTPr
++
 ABC10_2_1_000044078800_J23 AC279208 [32] MAP 17209-18024 AC279210 [32] 13858-14677
AC279213 [32] 42250->42372 *
AC279219 [32] 17209-18024
BK075720✤ [27] 709053-709864
BK075721✤ [27] 708974-709785
IMGT000293 [8,20] 709060-709879
IGLV3-21*01_S5562 MK308864 [39] (48) #c 1-290 *
IGLV3IGLV3-22 IGLV3-22*01 (47) F 22q11.2
RTPr
++
 AC279210 [32] MAP 5769-6297 V2-15 D87007 [23] 4950-5233 *
IMGT000225 [10,25] ° 688254-688782
IMGT000280 [29] ° 704333-704861
IMGT000293 [8,20] 700970-701498
3e(3e.272A12) Z73666 [17,42] 1-284 *
IGLV3IGLV3-22 IGLV3-22*02 (47) P (54) 22q11.2 IGLV3S3P X71967 [18] 256-543 *
IGLV3IGLV3-22 IGLV3-22*03 (47) F 22q11.2 ABC10_2_1_000044078800_J23 AC279208 [32] MAP 9121-9649 AC279213 [32] 33672-34200
AC279219 [32] 9121-9649
IGLV3IGLV3-22 IGLV3-22*04 P (21) 22q11.2 BK075720✤ [27] MAP 700958-701491 BK075721✤ [27] 700879-701412
IGLV3IGLV3-24 IGLV3-24*01 (47) P (22) 22q11.2 IGLV3S4P X71968 [18] 347-629 *
IGLV3IGLV3-24 IGLV3-24*02 (47) P (55) 22q11.2 V2-16P D86994 [23] MAP 32263-32546 * BK075721✤ [27] 690990-691659
IGLV3IGLV3-24 IGLV3-24*03 (47) P (23) 22q11.2 AC279213 [32] MAP 23782-24451 ABC11_000047999300_E7 AC279318 [32] 39846-40129 *
IMGT000293 [8,20] 691080-691749
IGLV3IGLV3-24 IGLV3-24*04 P (24) 22q11.2 ABC13_11_000048923500_G11 OL352727 [31] MAP 18614-19283
IGLV3IGLV3-24 IGLV3-24*05 P (25) 22q11.2 IMGT000225 [10,25] ° 678365-679034
IGLV3IGLV3-24 IGLV3-24*06 P (26) 22q11.2 IMGT000280 [29] ° MAP 694589-695112 BK075720✤ [27] 691214-691737
IGLV3IGLV3-25 IGLV3-25*01 (47) F 22q11.2
RTPr
++
 3m(3m.102D1) X97474 [42] 1-290 *
IGLV3IGLV3-25 IGLV3-25*02 (47) F 22q11.2
RTPr
++
 V2-17 D86994 [23] MAP 24447-24736 * BK075721✤ [27] 683308-683859
IGLV3IGLV3-25 IGLV3-25*03 (47) F 22q11.2
RTPr
++
 ABC11_2_1_000049528800_P17 AC279213 [32] MAP 16121-16672 ABC11_000047999300_E7 AC279318 [32] 31838-32389
BK075720✤ [27] 683437-683988
IMGT000225 [10,25] ° 670694-671245
IMGT000280 [29] ° 686812-687363
IMGT000293 [8,20] 683419-683970
IGGLL150 L29165 [16] 252->533 *
IGLV3-25*02_S7225 MK308865 [39] (48) #c 1-290 *
IGLV3IGLV3-26 IGLV3-26*01 (47) P (27) 22q11.2 ABC11_000047999300_E7 AC279318 [32] MAP 18435-18723 * BK075720✤ [27] 669826-670348
BK075721✤ [27] 669706-670228
V2-18P D86994 [23] 10810-11098 *
IMGT000225 [10,25] ° 657079-657601
IMGT000280 [29] ° 673398-673686 *
IMGT000293 [8,20] 669819-670341
3b(3b.57F5) X97467 [42] 1-289 *
IGLV3IGLV3-27 IGLV3-27*01 (47) F 22q11.2
RTPr
++
 V2-19 D86994 [23] MAP 5986-6269 * ABC11_000047999300_E7 AC279318 [32] 13413-13934
BK075720✤ [27] 664998-665519
BK075721✤ [27] 664881-665402
IMGT000225 [10,25] ° 652251-652772
IMGT000280 [29] ° 668376-668897
IMGT000293 [8,20] 664991-665512
IGLV3IGLV3-27 IGLV3-27*02 P (28) 22q11.2 IMGT000312 [8,20] MAP 659040-659560
IGLV3IGLV3-29 IGLV3-29*01 (47) P (29) 22q11.2 ABC11_000047999300_E7 AC279318 [32] MAP 6041-6708 BK075720✤ [27] 657621-658288
BK075721✤ [27] 657503-658170
V2-20P D87002 [23] 36200-36479 *
IMGT000225 [10,25] ° 644874-645541
IMGT000280 [29] ° 661003-661670
IMGT000293 [8,20] 657614-658281
3c(3c.97H8) Z73644 [17,42] 1-280 *
IGLV3IGLV3-30 IGLV3-30*01 (47) P (8) 22q11.2 3o(3o.75H1) Z73646 [17,42] 1-295 *
IGLV3IGLV3-30 IGLV3-30*02 (47) P (52) 22q11.2 V2-21P D87014 [23] MAP 36348-36642 * BK075720✤ [27] 615094-615626
BK075721✤ [27] 615027-615559
IMGT000225 [10,25] ° 602643-603175
IMGT000293 [8,20] 615078-615610
IGLV3IGLV3-30 IGLV3-30*03 P (30) 22q11.2 IMGT000280 [29] ° MAP 618456-618988
IGLV3IGLV3-30 IGLV3-30*04 P (30) 22q11.2 IMGT000312 [8,20] MAP 609072-609604
IGLV3IGLV3-31 IGLV3-31*01 (47) P (56) 22q11.2 V2-22P D87014 [23] MAP 22327-22616 * BK075720✤ [27] 601094-601625
BK075721✤ [27] 601026-601557
IMGT000225 [10,25] ° 588618-589149
IMGT000280 [29] ° 604658-604947 *
IMGT000293 [8,20] 601078-601609
3k(3k.61E11) X97469 [42] 1-290 *
IGLV3IGLV3-31 IGLV3-31*02 (47) P (31) 22q11.2 DPL17 Z22203 [41] 1-290 *
IGLV3IGLV3-32 IGLV3-32*01 (47) ORF (32) 22q11.2 V2-23P D87014 [23] MAP 11998-12526 BK075720✤ [27] 590966-591494
BK075721✤ [27] 590901-591429
IMGT000225 [10,25] ° 578492-579020
IMGT000280 [29] ° 594330-594858
IMGT000293 [8,20] 590950-591478
3i1(3i1.61E11) Z73645 [17,42] 1-284 *
IGLV4IGLV4-3 IGLV4-3*01 (47) F (57) 22q11.2
RTPr
++
 VlambdaN.2 X57828 [11] MAP 356-669 * BK075720✤ [27] 867746-868279
BK075721✤ [27] 867651-868186
5-1 D87024 [23] 38988-39301 *
IMGT000225 [10,25] ° 855464-855999
IMGT000280 [29] ° 871447-871982
IMGT000293 [8,20] 868082-868616
DPL24 Z22211 [41] 1-309 *
4c(4c127E5) Z73652 [17,42] 1-314 *
IGLV4IGLV4-7-1 IGLV4-7-1*01 P (33) 22q11.2 IMGT000225 [10,25] ° MAP 818593-819128 BK075720✤ [27] 830865-831400
BK075721✤ [27] 830771-831306
IMGT000280 [29] ° 834575-835110
IMGT000293 [8,20] 831199-831734
IGLV4IGLV4-10-1 IGLV4-10-1*01 P (33) 22q11.2 IMGT000225 [10,25] ° MAP 786818-787322 BK075720✤ [27] 799404-799908
IMGT000280 [29] ° 802805-803309
IMGT000293 [8,20] 799428-799932
IGLV4IGLV4-10-1 IGLV4-10-1*02 P (34) 22q11.2 IMGT000312 [8,20] MAP 793601-794105 BK075721✤ [27] 799309-799813
IGLV4IGLV4-60 IGLV4-60*01 (46) F 22q11.2
RTPr
++
 4a(4a.366F5) Z73667 [17,42] 1-297 *
IGLV4IGLV4-60 IGLV4-60*02 (46) F 22q11.2
RTPr
++
 V5-4 D87000 [23] MAP 12784-13305 BK075720✤ [27] 152789-153310
BK075721✤ [27] 152793-153314
IMGT000225 [10,25] ° 146124-146645
IGLV4IGLV4-60 IGLV4-60*03 (46) F 22q11.2
RTPr
++
 ABC13_11_000047487500_B16 AC279317 [32] MAP 7131-7652 V5-4 AF073885 [33] 1-297 *
IMGT000293 [8,20] 158822-159343
IGLV4IGLV4-60 IGLV4-60*04 (46) P (35) 22q11.2 AC279212 [32] MAP 13903-14423 IMGT000280 [29] ° 152768-153288
IGLV4IGLV4-69 IGLV4-69*01 (46) F 22q11.2
RTPr
++
 V5-6 D86993 [23] MAP 16540-17057 BK075720✤ [27] 21580-22097
BK075721✤ [27] 21582-22099
IMGT000225 [10,25] ° 14919-15436
IMGT000280 [29] ° 21580-22097
IMGT000293 [8,20] 21578-22095
IGLV8A1 L29806 [7] 720-1018 *
4b(4b.68B6) Z73648 [17,42] 1-299 *
IGLV4IGLV4-69 IGLV4-69*02 (46) F 22q11.2
RTPr
++
 lv801 U03868 [15] 161-459 *
IGLV5IGLV5-37 IGLV5-37*01 (42) F 22q11.2
RTPr
++
 IMGT000225 [10,25] ° MAP 411470-411999 BK075720✤ [27] 424084-424613
IMGT000280 [29] ° 427414-427943
IMGT000293 [8,20] 424097-424626
5e(5e.366F5) Z73672 [17,42] 1-312 *
IGLV5IGLV5-37 IGLV5-37*02 F 22q11.2 ABC10_2_1_000043666500_D13 OL352722 [31] 28121-28650
IGLV5IGLV5-37 IGLV5-37*03 F 22q11.2 ABC11_2_1_000047380400_O8 OL352725 [31] MAP 22260-22788 BK075721✤ [27] 424091-424620
IGLV5IGLV5-39 (63) IGLV5-39*01 (42) F 22q11.2
RTPr
++
 5a(5a.366F5) Z73668 [17,42] MAP 1-312 * IMGT000280 [29] ° 393335-393865
IGLV5IGLV5-39 (63) IGLV5-39*02 (42) F 22q11.2 Vlambda5 AF216776 [22] 181-492 *
IGLV5IGLV5-45 IGLV5-45*01 (42) F 22q11.2
RTPr
++
 5c(5c.366F5) Z73670 [17,42] 1-312 *
IGLV5IGLV5-45 IGLV5-45*02 (42) F 22q11.2
RTPr
++
 5c(5c.400B5) Z73671 [17,42] MAP 1-312 * BK075720✤ [27] 372589-373119
BK075721✤ [27] 372585-373115
IGLV5-1 U93494 [35] 274-585 *
IGLV5IGLV5-45 IGLV5-45*03 (42) F 22q11.2
RTPr
++
 IMGT000280 [29] ° MAP 366760-367290 AC279207 [32] 33864-34394
V4-2 D86999 [23] 15700-16011 *
IGLV5IGLV5-45 IGLV5-45*04 (42) F 22q11.2 KM455553 [40] MAP 1-531 IMGT000225 [10,25] ° 359939-360469
IMGT000293 [8,20] 372575-373105
IGLV5IGLV5-45 IGLV5-45*05 F 22q11.2 ABC10_2_1_000044093800_G12 OL352719 [31] 33534-34064
IGLV5IGLV5-48 IGLV5-48*01 (42) F 22q11.2 IMGT000312 [8,20] MAP 343458-343989 AC279207 [32] ORF (64) 10775-11306
BK075720✤ [27] 343490-344021
BK075721✤ [27] 343486-344017
V4-3 D87016 [23] 23145-23456 *
IMGT000280 [29] ORF (65) ° 343868-344179 *
IMGT000293 [8,20] ORF (65) 349516-350047
ABC10_2_1_000044093800_G12 OL352719 [31] ORF (65) 10487-11018
5d(5d.75A1) Z73649 [17,42] ORF 1-312 *
IGLV5IGLV5-48 IGLV5-48*02 (42) P (36) 22q11.2 KM455554 [40] MAP 1-533 IMGT000225 [10,25] ° 336865-337397
IGLV5IGLV5-52 IGLV5-52*01 (42) F 22q11.2
RTPr
++
 V4-4 D87018 [23] MAP 14641-15174
IGLV5IGLV5-52 IGLV5-52*01 (42) F 22q11.2
RTPr
++
 5b(5b.366F5) Z73669 [17,42] MAP 1-317 * BK075720✤ [27] 309287-309820
BK075721✤ [27] 309283-309816
IMGT000225 [10,25] ° 302657-303190
IMGT000280 [29] ° 309504-310037
IMGT000293 [8,20] 315311-315844
IGLV6IGLV6-57 IGLV6-57*01 (46) F 22q11.2
RTPr
++
 6a(6a.366F5) Z73673 [17,42] MAP 1-296 * BK075720✤ [27] 186395-186911
BK075721✤ [27] 186399-186915
V1-22 D86996 [23] 9533-9828 *
IGLV6S1 M87320 [6] 442-737 *
LV6SW-G X92337 [6] 269-564 *
IGLV6IGLV6-57 IGLV6-57*02 (46) F 22q11.2 KM455556 [40] MAP 1-517 IMGT000225 [10,25] ° 179724-180240
IMGT000280 [29] ° 186368-186884
IMGT000293 [8,20] 192415-192931
IGLV6IGLV6-57 IGLV6-57*03 (46) F 22q11.2 AC279220 [32] 214-730
IGLV6IGLV6-57 IGLV6-57*04 (46) F 22q11.2
RTPr
++
 IMGT000312 [8,20] MAP 186062-186578 IGLV6-57*01_S1429 MK308866 [39] #c 1-296 *
MW316677 [28] 63-358 *
IGLV6IGLV6-57 IGLV6-57*05 P (20) 22q11.2 ABC11_2_1_000049654800_O19 OL352713 [31] 16384-16898
IGLV7IGLV7-35 IGLV7-35*01 (42) P (37) 22q11.2 IMGT000225 [10,25] ° MAP 434127-434616 BK075720✤ [27] 446742-447231
BK075721✤ [27] 446750-447239
V3-1P D87009 [23] 31463-31757 *
IMGT000280 [29] ° 450233-450527 *
IMGT000293 [8,20] 446752-447241
7c(7c.11.2) Z73660 [17,42] 1-295 *
IGLV7IGLV7-43 IGLV7-43*01 (42) F 22q11.2
RTPr
++
 Vlambda7.1 X14614 [1] MAP 414-707 * BK075720✤ [27] 391598-392074
BK075721✤ [27] 391594-392070
V3-2 D86999 [23] 34671-34964 *
IMGT000225 [10,25] ° 378977-379453
IMGT000280 [29] ° 385800-386276
IMGT000293 [8,20] 391605-392081
4A X01015 [2] 375-668 *
DPL18 Z22204 [41] 1-291 *
7a(7a.2.3) Z73659 [17,42] 1-294 *
IGLV7IGLV7-46 IGLV7-46*01 (42) F 22q11.2
RTPr
++
 IMGT000280 [29] ° MAP 360394-360871 AC279207 [32] 27495-27972
IMGT000293 [8,20] 366208-366685
DPL19 Z22205 [41] 1-294 *
7b(7b.400B5) Z73674 [17,42] 1-294 *
IGLV7IGLV7-46 IGLV7-46*02 (42) F 22q11.2
RTPr
++
 V3-3 D86999 [23] MAP 9299-9592 * IMGT000225 [10,25] ° 353573-354051
IGLV7IGLV7-46 IGLV7-46*03 (42) P (58) 22q11.2 DPL20 Z22210 [41] 1-293 *
IGLV7IGLV7-46 IGLV7-46*04 (42) F 22q11.2 MW316675 [28] MAP 210-687 BK075720✤ [27] 366216-366693
BK075721✤ [27] 366212-366689
ABC14_4_1_000050201700_H24 OL352718 [31] 32970-33447
IGLV7IGLV7-46 IGLV7-46*05 F 22q11.2 ABC10_2_1_000044093800_G12 OL352719 [31] 27167-27644
IGLV8IGLV8-61 IGLV8-61*01 (46) F 22q11.2
RTPr
++
 V3-4 D87022 [23] MAP 32364-32854 BK075720✤ [27] 89360-89850
BK075721✤ [27] 89359-89849
IMGT000225 [10,25] ° 82686-83176
IMGT000280 [29] ° 89340-89830
IMGT000293 [8,20] 89353-89843
VL8 S39395 [43] 180-474 *
TL7 U03635 [26] 454-749 *
FL7 U03639 [26] 454-749 *
DPL21 Z22206 [41] 1-294 *
8a(8a.88E1) Z73650 [17,42] 1-296 *
IGLV8IGLV8-61 IGLV8-61*02 (46) F 22q11.2
RTPr
++
 BL7 U03637 [26] MAP 454-749 *
IGLV8IGLV8-61 IGLV8-61*03 (46) F (59) 22q11.2 IGLV8 AF266511 [37] <1->247 *
IGLV9IGLV9-49 IGLV9-49*01 (42) F (38) 22q11.2
RTPr
++
 AC279207 [32] MAP (60) 1063-1611 BK075720✤ [27] 333777-334325
BK075721✤ [27] 333773-334321
IMGT000225 [10,25] ° 327149-327697
IMGT000280 [29] ° 333974-334522
IMGT000293 [8,20] 339800-340348
DPL22 Z22207 [41] 1->312 *
9a(9a.366F5) Z73675 [17,42] 1-317 *
IGLV9IGLV9-49 IGLV9-49*02 (42) F (57) 22q11.2
RTPr
++
 V5-2 D87016 [23] 13445-13761 *
IGLV9IGLV9-49 IGLV9-49*03 (42) F (57) 22q11.2
RTPr
++
 lv901e U03869 [15] 206-522 *
IGLV9IGLV9-49 IGLV9-49*04 P (28) 22q11.2 ABC10_2_1_000044093800_G12 OL352719 [31] 774-1321
IGLV10IGLV10-54 IGLV10-54*01 (46) F 22q11.2
RTPr
++
 IMGT000312 [8,20] MAP 205068-205571 AC279220 [32] 19204-19707
10a(10a.872F9) Z73676 [17,42] 1-296 *
IGLV10IGLV10-54 IGLV10-54*02 (46) F 22q11.2
RTPr
++
 V1-20 D86996 [23] MAP 28518-28813 * BK075720✤ [27] 205389-205892
BK075721✤ [27] 205392-205895
IMGT000225 [10,25] ° 198732-199235
IGLV10IGLV10-54 IGLV10-54*03 (46) P (39) 22q11.2 gVlambdaX-4.4 S70116 [36] 304-599 *
IGLV10IGLV10-54 IGLV10-54*04 (46) F 22q11.2
RTPr
++
 MW316678 [28] MAP 148-651 IMGT000280 [29] ° 205373-205876
IMGT000293 [8,20] 211418-211921
IGLV10-54*01_S4180 MK308862 [39] #c 1-296 *
IGLV10IGLV10-54 IGLV10-54*05 F 22q11.2 ABC11_2_1_000049654800_O19 OL352713 [31] 35336-35839
IGLV10IGLV10-54 IGLV10-54*06 F 22q11.2 ABC13_11_000049737400_A20 OL352724 [31] 30288-30791
IGLV10IGLV10-67 IGLV10-67*01 (46) P (52) 22q11.2 V1-25P D86993 [23] MAP 28998-29498 BK075721✤ [27] 34039-34539
IMGT000225 [10,25] ° 27377-27877
10b(10b.4E7) Z73651 [17,42] 1-295 *
IGLV10IGLV10-67 IGLV10-67*02 (46) P (40) 22q11.2 gVlambdaX-5.5 X92335 [36] 296-588 *
IGLV10IGLV10-67 IGLV10-67*03 P (37) 22q11.2 IMGT000280 [29] ° MAP 34036-34536 BK075720✤ [27] 34037-34537
IMGT000293 [8,20] 34035-34535
IGLV11IGLV11-55 IGLV11-55*01 (46) ORF (61) 22q11.2 V4-6 D86996 [23] MAP 15396-15707 * AC279220 [32] 6080-6601
BK075720✤ [27] 192265-192786
BK075721✤ [27] 192269-192790
IMGT000293 [8,20] 198285-198806
IGLV11IGLV11-55 IGLV11-55*02 (46) ORF (41) 22q11.2 KM455555 [40] MAP 1-522 IMGT000225 [10,25] ° 185600-186121
IMGT000280 [29] ° 192245-192766
IGLV11IGLV11-55 IGLV11-55*03 P (20) 22q11.2 ABC11_2_1_000049654800_O19 OL352713 [31] 22232-22750

✤ : NCBI accession number that correspond to a previously internal IMGT accession number. See the correspondence table.

IMGT notes: ↑
  1. in frame STOP-CODON in V-REGION at positions AA 44 and 111
  2. several STOP-CODON in V-REGION
  3. Frameshift in L-PART1, STOP-CODON in V-REGION
  4. pseudogene because of STOP-CODON in FR3-IMGT and CDR3-IMGT
  5. frameshift in L-PART1, several STOP-CODON in V-REGION
  6. frameshift in L-PART1 causing defectuous DONOR-SPLICE, several STOP-CODON in V-REGION
  7. frameshift in V-REGION: deletion of 13 nts in FR2-IMGT, insertion of 1nt in FR3-IMGT
  8. pseudogene because frameshift in V-REGION
  9. frameshift in L-PART1: deletion of 1 nt causing defectuous DONOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
  10. no 2nd-CYS: Phe instead of Cys
  11. no 2nd-CYS: Phe instead of Cys, noncanonical V-HEPTAMER: catagtg instead of cacagtg
  12. no ACCEPTOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
  13. pseudogene because of STOP-CODON and frameshift in V-REGION
  14. frameshift in L-PART1 causing defectuous DONOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
  15. frameshift in L-PART1, frameshifts in V-REGION: several insertions and deletions
  16. Pseudogene due to a DELETION in the IMGT-CDR1 leading to a frameshift.
  17. no INIT-CODON
  18. STOP-CODON in V-REGION: position 109
  19. frameshift in L-PART1, STOP-CODON in CDR3-IMGT: position 109
  20. frameshifts in V-REGION: several insertions and deletions
  21. frameshift in V-REGION: insertion of 5 nt in FR2-IMGT
  22. pseudogene because STOP-CODON in FR2-IMGT
  23. frameshift in L-PART1, frameshift in V-REGION: deletion of 2 nt and 4 nt in FR3-IMGT
  24. frameshift in L-PART1: deletion of 1 nt causing defectuous DONOR-SPLICE, STOP-CODON in V-REGION: position 40, frameshifts in V-REGION: several insertions and deletions
  25. frameshift in L-PART1 causing defectuous DONOR-SPLICE, STOP-CODON in V-REGION: position 40, frameshifts in V-REGION: deletion of 2 nt and deletion of 4 nt in FR3-IMGT
  26. frameshift in L-PART1:deletion of 1 nt causing defectuous DONOR-SPLICE, STOP-CODON in V-REGION: position 40, frameshifts in V-REGION: deletion of 2 nt and deletion of 4 nt in FR3-IMGT
  27. No INIT-CODON, STOP-CODON in FR2-IMGT: position 48, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
  28. frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
  29. STOP-CODON in FR2-IMGT: position 40, frameshift in V-REGION: deletion of 5 nts in FR3-IMGT
  30. frameshift in V-REGION: deletion of 4 nt in FR3-IMGT
  31. because of STOP-CODON in frame, unusual V-HEPTAMER sequence cgcggtg instead of cacagtg
  32. Non-canonical ACCEPTOR_SPLICE: nggnn instead of nagnn, and 2nd-CYS replaced by Tyr in V-EXON
  33. no INIT-CODON: Thr instead of Met, several STOP-CODON in V-REGION
  34. no L-PART1, frameshifts in V-REGION: several deletions
  35. frameshift in V-REGION: deletion of 1 nt in FR2-IMGT
  36. in frame STOP-CODON in V-REGION and non canonical V-NONAMER: acgaaaacc instead of accaaaacc
  37. frameshift in V-REGION: insertion of 1 nt in FR3-IMGT
  38. STOP-CODON at position 106 (last 3' codon of germline CDR3-IMGT) may disappear during rearrangements
  39. frameshift in L-PART1
  40. pseudogene because STOP-CODON in FR1-IMGT and frameshift in V-REGION
  41. unexpected V-SPACER length (19 nt instead of 23 nt)
  42. V-CLUSTER: B.
  43. Non-canonical ACCEPTOR-SPLICE: nacnn instead of nagnn.
  44. STOP-CODON at position 99 in FR3-IMGT.
  45. Non-conserved OCTAMER sequence: ctgcacaa instead of atttgcat, non-conserved TATA_BOX, and unusual V-NONAMER sequence: agaagaacc instead of acaaaaacc.
  46. V-CLUSTER: C.
  47. V-CLUSTER: A.
  48. Inferred allele: IMGT-NC_Report_2020-3-1120_Homsap_IGKV_IGLV.
  49. Unusual V-HEPTAMER sequence: catagtg instead of cacagtg.
  50. STOP-CODONs at position 18 in FR1-IMGT and at position 44 in FR2-IMGT.
  51. CONSERVED-TRP replaced by Ser in V-EXON, frameshift in FR3-IMGT.
  52. frameshift in V-REGION: deletion of 13 nts in FR2-IMGT, insertion of 1nt in FR3-IMGT.
  53. IGLV3-12*01 has been described as functional in Z73658 (V-GENE partial in 5' and 3'). However in AC279423, IGLV3-12*01 (with a complete V-GENE) the functionality is pseudogene because no INIT-CODON.
  54. DELETION of 1 pb in codon 47, and INSERTION of 5 nt between positions 50 to 51, leading to frameshifts in FR2-IMGT.
  55. STOP-CODON in FR2-IMGT: position 40, frameshift in V-REGION: deletion of 5 nts in FR3-IMGT.
  56. STOP-CODONs at position 17 in FR1-IMGT and at position 55 in FR2-IMGT.
  57. Since the STOP-CODON at the 3' end of the V-REGION can be deleted by rearrangement, the V-GENE is considered as functional.
  58. DELETION of 1 nt in codon 91 leading to a frameshift in FR3-IMGT.
  59. V-REGION is partial: AA 1 to 3 are missing (partial FR1-IMGT), AA 100 to 104 are missing (partial FR3-IMGT) and no CDR3-IMGT.
  60. STOP-CODON at position 106 (last 3' codon of germline CDR3-IMGT) may disappear during rearrangements.
  61. Unusual V-SPACER length: 19 nt instead of 23 nt.
  62. frameshift in L-PART1: deletion of 2 nt
  63. IGLV5-39 becomes functional because it has been found rearranged (AF063696,AF063751).
  64. Unusual V-HEPTAMER sequence: tacagtg instead of cacagtg
  65. noncanonical V-HEPTAMER: tacagac instead of cacagtg
IMGT references: ↑
  1. Alexandre D. et al., First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus, Nucleic Acids Res, vol. 17, no. 10, 1989, pp. 3975-3975. DOI: 10.1093/nar/17.10.3975
  2. Anderson M.L.M. et al., The isolation of a human Ig V lambda gene from a recombinant library of chromosome 22 and estimation of its copy number, Nucleic Acids Res, vol. 12, no. 17, 1984, pp. 6647-6661. DOI: 10.1093/nar/12.17.6647
  3. Berek C. et al., Human lambda light chain germline genes: polymorphism in the IGVL2 gene family, Immunogenetics, vol. 46, no. 6, 1997, pp. 533-534. DOI: 10.1007/s002510050317
  4. Bernard F. et al., Genomic sequence of IGLV1S2, a human immunoglobulin variable lambda gene belonging to subgroup I, Nucleic Acids Res, vol. 18, no. 23, 1990, pp. 7139-7139. DOI: 10.1093/nar/18.23.7139
  5. Brockly F. et al., First nucleotide sequence of a human immunoglobulin variable lambda gene belonging to subgroup II, Nucleic Acids Res, vol. 17, no. 10, 1989, pp. 3976-3976. DOI: 10.1093/nar/17.10.3976
  6. Ch'ang L.Y. et al., Identification and characterization of a functional human Ig V lambda VI germline gene, Mol. Immunol, vol. 31, no. 7, 1994, pp. 531-536. DOI: 10.1016/0161-5890(94)90040-X
  7. Ch'ang L.Y. et al., Molecular characterization of a human V lambda VIII germline gene, Mol. Immunol, vol. 32, no. 1, 1995, pp. 49-55. DOI: 10.1016/0161-5890(94)00135-N
  8. Chu et al., Approaching an Error-Free Diploid Human Genome Assembly of East Asian Origin, (misc) bioRxivorg, 2025, DOI: 10.1101/2025.08.01.667781
  9. Chu et al., Direct Submission, Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation. Submitted (16-AUG-2025). NGDC, Beijing, 100101, China.
  10. Cole,C.G. et al., Finishing the finished human chromosome 22 sequence, Genome Biol, vol. 9, no. 5, 2008, pp. R78-.
  11. Combriato G. and Klobeck H.G, V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism, Eur. J. Immunol, vol. 21, no. 6, 1991, pp. 1513-1522. PUBMED: 1904362
  12. Daley M.D. et al., Molecular analysis of human immunoglobulin V lambda germline genes: subgroups V lambda III and V lambda IV, Mol. Immunol, vol. 29, no. 12, 1992, pp. 1515-1518. DOI: 10.1016/0161-5890(92)90226-N
  13. Daley M.D. et al., Molecular characterization of the human immunoglobulin V lambda I germline gene repertoire, Mol. Immunol, vol. 29, no. 9, 1992, pp. 1031-1042. DOI: 10.1016/0161-5890(92)90034-U
  14. Deftos M. et al., Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors, J. Clin. Invest, vol. 93, no. 6, 1994, pp. 2545-2553. DOI: 10.1172/JCI117265
  15. Deftos M. et al., Utilization of a potentially universal downstream primer in the rapid identification and characterization of V lambda genes from two new human V lambda gene families, Scand. J. Immunol, vol. 39, no. 1, 1994, pp. 95-103. PUBMED: 8290898
  16. Fang Q. et al., Human rheumatoid factors with restrictive specificity for rabbit immunoglobulin G: auto- and multi-reactivity, diverse VH gene segment usage and preferential usage of V lambda IIIb, J. Exp. Med, vol. 179, no. 5, 1994, pp. 1445-1456. DOI: 10.1084/jem.179.5.1445
  17. Frippiat J.P, 1995.
  18. Frippiat J.P. and Lefranc M.P, Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV): restriction map and sequences of new V lambda III genes, Mol. Immunol, vol. 31, no. 9, 1994, pp. 657-670. DOI: 10.1016/0161-5890(94)90175-9
  19. Frippiat J.P. et al., First genomic sequence of a human Ig variable lambda gene belonging to subgroup III, Nucleic Acids Res, vol. 18, no. 23, 1990, pp. 7134-7134. DOI: 10.1093/nar/18.23.7134
  20. He et al., T2T YAO: A Telomere to telomere Assembled Diploid Reference Genome for Han Chinese, Genomics Proteomics & Bioinformatics 21(6): 1085–1100 (2023), DOI: 10.1016/j.gpb.2023.08.001
  21. Irigoyen M. et al., Molecular analysis of the human immunoglobulin V lambda II gene family, J. Clin. Invest, vol. 94, no. 2, 1994, pp. 532-538. PUBMED: 8040307
  22. Junta C.M. and Passos G.A.S, Genomic EcoRI polymorphism and cosmid sequencing reveal an insertion/deletion and a new IGLV5 allele in the human immunoglobulin lambda variable locus (22q11.2/IGLV), Immunogenetics, vol. 55, no. 1, 2003, pp. 10-15. PUBMED: 12679855
  23. Kawasaki K. et al., One-megabase sequence analysis of the human immunoglobulin lambda gene locus, Genome Res, vol. 7, no. 3, 1997, pp. 250-261. PUBMED: 9074928
  24. Kueppers R. et al., Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction, Am. J. Pathol, vol. 147, no. 3, 1995, pp. 806-814. PUBMED: 7677192
  25. Lander,E.S. et al., Initial sequencing and analysis of the human genome, International Human Genome Sequencing Consortium Nature, vol. 409, no. 6822, 2001, pp. 860-921.
  26. Lee G. et al., Somatically mutated member of the human V lambda VIII gene family encodes anti-myelin-associated glycoprotein (MAG) activity, J. Neuroimmunol, vol. 51, no. 1, 1994, pp. 45-52. DOI: 10.1016/0165-5728(94)90127-9
  27. Manso T. et al., IMGT(R) databases, related tools and web resources through three main axes of research and development, Nucleic Acids Res, vol. 50, no. D1, 2022, pp. 1262-1272.
  28. Mikocziova I. et al., Germline polymorphisms in immunoglobulin light chain V genes, Unpublished.
  29. Nurk S. et al., The complete sequence of a human genome, Science, vol. 376, no. 6588, 2022, pp. 44-53. PUBMED: 35357919
  30. Olee T. et al., Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response, J. Exp. Med, vol. 175, no. 3, 1992, pp. 831-842. DOI: 10.1084/jem.175.3.831
  31. Rodriguez,O.L. et al., An ethnically diverse genomic reference resource for human immune receptor gene loci, Unpublished.
  32. Rodriguez O.L. et al., An ethnically diverse genomic reference resource for human immune receptor gene loci, Unpublished.
  33. Semrad T.J. et al., Mutational analysis of immunoglobulin germline derived Vlambda4A light chains in rheumatoid arthritis, Clin. Immunol, vol. 99, no. 2, 2001, pp. 276-282. DOI: 10.1006/clim.2001.5006
  34. Siminovitch K.A. et al., A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation, J. Clin. Invest, vol. 84, no. 5, 1989, pp. 1675-1678. PUBMED: 2509520
  35. Solomon A. et al., Identification and characterization of a human Vlambda5 (T1) germline gene that encodes structurally unique lambda light chains, Mol. Immunol, vol. 34, no. 6, 1997, pp. 463-470. DOI: 10.1016/S0161-5890(97)00038-2
  36. Stiernholm N.B. et al., Identification of a new human V lambda gene family--V lambda X, J. Immunol, vol. 152, no. 10, 1994, pp. 4969-4975. PUBMED: 8176215
  37. Tamia-Ferreira M.C. et al., Sequencing germinative and cDNA of human immunoglobulin lambda variable 8 (IGLV8) gene of SLE patients and normal individuals, Unpublished.
  38. Vasicek T.J. and Leder P, Structure and expression of the human immunoglobulin lambda genes, J. Exp. Med, vol. 172, no. 2, 1990, pp. 609-620. DOI: 10.1084/jem.172.2.609
  39. Vazquez Bernat N. et al., High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis, Front Immunol, vol. 10, 2019, PUBMED: 31024532
  40. Watson C.T. et al., Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity, Genes Immun, vol. 16, no. 1, 2015, pp. 24-34. DOI: 10.1038/gene.2014.56
  41. Williams S.C. and Winter G, Cloning and sequencing of human immunoglobulin V lambda gene segments, Eur. J. Immunol, vol. 23, no. 7, 1993, pp. 1456-1461. PUBMED: 7916694
  42. Williams S.C. et al., Sequence and evolution of the human germline V lambda repertoire, J. Mol. Biol, vol. 264, no. 2, 1996, pp. 220-232. DOI: 10.1006/jmbi.1996.0636
  43. Winkler T.H. et al., Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas, Eur. J. Immunol, vol. 22, no. 7, 1992, pp. 1719-1728. PUBMED: 1623920