Citing IMGT databases: Manso T. et al. IMGT® databases, related tools and web resources through three main axes of research and development. Nucleic Acids Res. 2022 Jan 7;50(D1):D1262-D1272. doi: 10.1093/nar/gkab1136 PMID: 34875068 Free PMC article.
Program version: v. 

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: a scoring system is employed to signify the frequency of occurrences of a specific allele within sequence data. A single star () indicates that no instances of the allele have been identified in the literature. Two stars () indicate the discovery of one literature sequence containing the allele. If more than one literature sequence is found to contain the allele, it is designated with three stars (). In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

The 3 House mouse (Mus musculus) IGLV subgroups belong to three clans (Figure IGLV clans). Clans comprise, respectively:

Click here for Number of genes as deduced by RFLP analysis.

Gene table of house mouse (Mus musculus) IGLV IMGT group:
IMGT sub­groupIMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		R T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesStrainAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)		Secondary
accession
numbers		Clone namesStrainAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)
IGLV1IGLV1 IGLV1*01 F 16A3 (13.0 cM)
RTPr
++
 V1 BALB/c J00590 [2,3] MAP 93-575 129S1_SvImJ IMGT000124 184958-185440
BALB/c V00811 [3] 93-575
A1-13/eVl1 BALB/c X58409 [3,13] 264-746
BALB_cJ IMGT000126 184970-185452
CM001009.3 C57BL/6J IMGT000117 [4,5] 185235-185717
DBA_2J IMGT000134 184901-185383
NOD/SCID IMGT000211 [10] 185223-185705
IGLV1IGLV1 IGLV1*02 F 16A3 (13.0 cM) M315/eVl1 BALB/c X58417 [3,13] 264-746
IGLV1IGLV2 IGLV2*01 F 16A3 (13.0 cM)
RTPr
++
 V2 J00599 [11,12] 82-564 V00815 [12] 82-565
IGLV1IGLV2 IGLV2*02 F 16A3 (13.0 cM)
RTPr
++
 J558/eVl2 BALB/c X58412 [12,13] MAP 148-630 129S1_SvImJ IMGT000124 9559-10041
BALB/c X58418 [12,13] 148-631
M315e/Vl2 BALB/c X58423 [12,13] 148-631
BALB/c X58424 [12,13] 148-631
BALB_cJ IMGT000126 9558-10040
CM001009.3 C57BL/6J IMGT000117 [4,5] 9851-10333
DBA_2J IMGT000134 9519-10001
NOD/SCID IMGT000211 [10] 9851-10333
IGLV2IGLV3 (2) IGLV3*01 F 16A3 (13.0 cM)
RTPr
++
 Lg1 BALB/c M34597 [8] MAP 59-571 129S1_SvImJ IMGT000124 28721-29232
VLx(Vlambdax) BALB/c D38129 [8] 59-571
Y31 (lambda x) BALB/c M34598 [7-9] #c 69-379 *
BALB_cJ IMGT000126 28720-29231
CM001009.3 C57BL/6J IMGT000117 [4,5] 29016-29527
DBA_2J IMGT000134 28681-29192
NOD/SCID IMGT000211 [10] 29013-29524
IGLV3 (3)IGLV4 IGLV4*01 [F] 16A3 (13.0 cM)
RTPr
++
 MBK2 MBK AF357985 [1] (1) ° <1->245 * SD26 M94349 [6] #c <67-321 *
IGLV3 (3)IGLV5 IGLV5*01 [F] 16A3 (13.0 cM)
RTPr
++
 PWK1 PWK AF357981 [1] (1) ° <1->245 * CZ81 M94351 [6] #c <58-312 *
IGLV3 (3)IGLV6 IGLV6*01 [F] 16A3 (13.0 cM) PWK3 PWK AF357979 [1] (1) ° <1->245 *
IGLV3 (3)IGLV6 IGLV6*02 [F] 16A3 (13.0 cM) MAI2 MAI AF357983 [1] (1) ° <1->245 *
IGLV3 (3)IGLV6 IGLV6*03 [F] 16A3 (13.0 cM) MBK4 MBK AF357987 [1] (1) ° <1->245 *
IGLV3 (3)IGLV7 IGLV7*01 [F] 16A3 (13.0 cM) PWK2 PWK AF357980 [1] (1) ° <1->245 *
IGLV3 (3)IGLV7 IGLV7*02 [F] 16A3 (13.0 cM) MBK1 MBK AF357984 [1] (1) ° <1->245 *
IGLV3 (3)IGLV8 IGLV8*01 [F] 16A3 (13.0 cM)
RTPr
++
 MAI1 MAI AF357982 [1] (1) ° <1->245 *
IGLV3 (3)IGLV8 IGLV8*02 [F] 16A3 (13.0 cM) MBK3 MBK AF357986 [1] (1) ° <1->245 *
IMGT notes: ↑
  1. Partial V-REGION: partial FR1-IMGT (AA 1 to 4 are absent) and partial FR3-IMGT (AA 99 to 104 are absent).
  2. The last codon of the CDR3-IMGT is a STOP-CODON which may disappear during rearrangements.
  3. Gene identification needs to be confirmed with genomic mapping. Genes belonging to the IGLV3 subgroup may vary from 0 to at least 5, depending from Mus musculus strains as deduced from RFLP analysis [11]. The IGLV3 subgroup is absent in BALB/c and in other laboratory mice.
IMGT references: ↑
  1. Amrani Y.M. et al., The Ig light chain restricted B6.kappa(-)lambda(SEG) mouse strain suggests that the IGL locus genomic organization is subject to constant evolution, Immunogenetics, vol. 54, no. 2, 2002, pp. 106-119. DOI: 10.1007/s00251-002-0448-6
  2. Arp B. et al., Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain, Nature, vol. 298, no. 5870, 1982, pp. 184-187. DOI: 10.1038/298184a0
  3. Bernard O. et al., Sequences of mouse immunoglobulin light chain genes before and after somatic changes, Cell, vol. 15, no. 4, 1978, pp. 1133-1144. DOI: 10.1016/0092-8674(78)90041-7
  4. Church,D.M. et al., Lineage-specific biology revealed by a finished genome assembly of the mouse, PLoS Biol (2009), PUBMED: 19468303
  5. Church,D.M. et al., Modernizing reference genome assemblies, PLoS Biol, vol. 9, no. 7, 2011, PUBMED: 21750661
  6. Reidl L.S. et al., Wild mice express an Ig V lambda gene that differs from any V lambda in BALB/c but resembles a human V lambda subgroup, J. Immunol, vol. 149, no. 2, 1992, pp. 471-480. PUBMED: 1378065
  7. Sanchez P. et al., A new variable region in mouse immunoglobulin lambda light chains, J. Exp. Med, vol. 166, no. 1, 1987, pp. 265-270. DOI: 10.1084/jem.166.1.265
  8. Sanchez P. et al., Mouse V lambda x gene sequence generates no junctional diversity and is conserved in mammalian species, J. Immunol, vol. 144, no. 7, 1990, pp. 2816-2820. PUBMED: 2108215
  9. Sanchez P. et al., Structure of a third murine immunoglobulin lambda light chain variable region that is expressed in laboratory mice, Proc. Natl. Acad. Sci. U.S.A, vol. 84, no. 24, 1987, pp. 9185-9188. PUBMED: 3122215
  10. Schmid-Siegert E. et al., Reference mouse strain assemblies for BALB/c Nude and NOD/SCID mouse models, Unpublished.
  11. Tonegawa S. et al., Organization of immunoglobulin genes, Cold Spring Harb. Symp. Quant. Biol, vol. 42, 1978, pp. 921-931. PUBMED: 98276
  12. Tonegawa S. et al., Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain, Proc. Natl. Acad. Sci. U.S.A, vol. 75, no. 3, 1978, pp. 1485-1489. DOI: 10.1073/pnas.75.3.1485
  13. Weiss S. et al., Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chains, EMBO J, vol. 6, no. 4, 1987, pp. 927-932. PUBMED: 3109891