IMGT Repertoire (IG and TR)

Lists of human (Homo sapiens) IG and TR genes, groups, major loci and orphons and links between IMGT/GENE-DB, HGNC, NCBI Gene and OMIM

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IG major loci: Human

There are 3 major loci for the immunoglobulin (IG) genes and 12 IG chromosomal orphon sets [1].

IMGT major loci and links with HGNC, NCBI Gene and OMIM

IMGT locus name	IMGT locus definition	Chromosomal localization	HGNC	NCBI Gene	OMIM
IGH locus	Immunoglobulin heavy locus	14q32.33	IGH	3492	-
IGK locus	Immunoglobulin kappa locus	2p11.2	IGK	50802	-
IGL locus	Immunoglobulin lambda locus	22q11.2	IGL	3535	-

Portail to gene content in Gene tables

Genes of the human IG loci belong to ten groups:

The human IGH locus at 14q32.33 comprises genes belonging to four groups: IGHV, IGHD, IGHJ and IGHC [1].
The human IGK locus at 2p11.2 comprises genes belonging to three groups: IGKV, IGKJ and IGKC [1].
The human IGL locus at 22q11.2 comprises genes belonging to three groups: IGLV, IGLJ and IGLC [1].

Number of genes per locus

IMGT Posters

Questions and answers (IMGT Education)

Nomenclature and overview of the human immunoglobulin genes

IMGT reference:
[1]	Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, 458 pages (2001) ISBN:012441351X.

See also:

Created:: 30/01/2001
Last updated:: 03/10/2025 19:10
Authors:: Véronique Giudicelli and Marie-Paule Lefranc
Editors:: Elodie Foulquier, Chantal Ginestoux